- Blockade of Oxidative Stress by Vitamin C Ameliorates Albuminuria and Renal Sclerosis in Experimental Diabetic Rats
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Lee EY, Lee MY, Hong SW, Chung CH, Hong SY
- KMID: 1122624
- Yonsei Med J.
- 2007 Oct;48(5):847-855.
- doi: 10.3349/ymj.2007.48.5.847
PURPOSE: Oxidative stress has been suggested to play a role as a common mediator of apoptosis and kidney damage in diabetes. However, it is uncertain whether the apoptosis occurs... -
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- Bilirubin protects grafts against nonspecific inflammation-induced injury in syngeneic intraportal islet transplantation
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Zhu H, Wang J, Jiang H, Ma Y, Pan S, Reddy S, Sun X
- KMID: 994397
- Exp Mol Med.
- 2010 Nov;42(11):739-748.
- doi: 10.3858/emm.2010.42.11.075
Nonspecific inflammatory response is the major cause for failure of islet grafts at the early phase of intraportal islet transplantation (IPIT). Bilirubin, a natural product of heme catabolism, has displayed... -
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- Effects of N-Acetylcysteine on Nicotinamide Dinucleotide Phosphate Oxidase Activation and Antioxidant Status in Heart, Lung, Liver and Kidney in Streptozotocin-Induced Diabetic Rats
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Lei S, Liu Y, Liu H, Yu H, Wang H, Xia Z
- KMID: 1120195
- Yonsei Med J.
- 2012 Mar;53(2):294-303.
- doi: 10.3349/ymj.2012.53.2.294
PURPOSE: Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress plays a key role in the pathogenesis of diabetic complications. Nicotinamide dinucleotide phosphate (NADPH) oxidase is one of... -
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- Effect of the combination of metformin and fenofibrate on glucose homeostasis in diabetic Goto-Kakizaki rats
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Oh TJ, Shin JY, Kang GH, Park KS, Cho YM
- KMID: 2154249
- Exp Mol Med.
- 2013 Jul;45(7):e30.
Metformin has been reported to increase the expression of the glucagon-like peptide-1 (GLP-1) receptor in pancreatic beta cells in a peroxisome proliferator-activated receptor (PPAR)-alpha-dependent manner. We investigated whether a PPARalpha... -
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- Antidiabetic Effects of Corni Fructus Extract in Streptozotocin-Induced Diabetic Rats
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Gao D, Li Q, Gao Z, Wang L
- KMID: 1716865
- Yonsei Med J.
- 2012 Jul;53(4):691-700.
- doi: 10.3349/ymj.2012.53.4.691
PURPOSE: Diabetes is the leading cause of end-stage renal failure. The present study was undertaken to characterize the effects of Corni Fructus on diabetic nephropathy in streptozotocin-induced diabetic rats and... -
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- The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats
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Kim SH, Jang YW, Hwang P, Kim HJ, Han GY, Kim CW
- KMID: 1120141
- Exp Mol Med.
- 2012 Jan;44(1):45-51.
- doi: 10.3858/emm.2012.44.1.004
Diabetic nephropathy (DN) is a progressive kidney disease that is caused by injury to kidney glomeruli. Podocytes are glomerular epithelial cells and play critical roles in the glomerular filtration barrier.... -
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- Aldose Reductase Inhibitor Ameliorates Renal Vascular Endothelial Growth Factor Expression in Streptozotocin-Induced Diabetic Rats
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Sung JK, Koh JH, Lee MY, Kim BH, Nam SM, Kim JH, Yoo JH, Kim SH, Hong SW, Lee EY, Choi R, Chung CH
- KMID: 1074990
- Yonsei Med J.
- 2010 May;51(3):385-391.
- doi: 10.3349/ymj.2010.51.3.385
PURPOSE: The vascular endothelial growth factor (VEGF) expression of podocyte is one of the well-known major factors in development of diabetic nephropathy. In this study, we investigated the effects of... -
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