- Protective Effect of Recombinant Adeno-Associated Virus 2/8-Mediated Gene Therapy from the Maternal Hyperphenylalaninemia in Offsprings of a Mouse Model of Phenylketonuria
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Jung SC, Park JW, Oh HJ, Choi JO, Seo KI, Park ES, Park HY
- KMID: 1783076
- J Korean Med Sci.
- 2008 Oct;23(5):877-883.
- doi: 10.3346/jkms.2008.23.5.877
Phenylketonuria (PKU) is an autosomal recessively inherited metabolic disorder caused by a deficiency of phenylalanine hydroxylase (PAH). The accumulation of phenylalanine leads to severe mental and psychomotor retardation, and the... -
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- Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo
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Liu Y, Okada T, Nomoto T, Ke X, Kume A, Ozawa K, Xiao S
- KMID: 1094657
- Exp Mol Med.
- 2007 Apr;39(2):170-175.
The aims of this study were to evaluate the expression of enhanced green fluorescent protein (EGFP) driven by 6 different promoters, including cytomegalovirus IE enhancer and chicken beta-actin promoter (CAG),... -
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- Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria
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Park ES, Oh HJ, Kruger WD, Jung SC, Lee JS
- KMID: 1115943
- Exp Mol Med.
- 2006 Dec;38(6):652-661.
Homocystinuria is a metabolic disorder caused by a deficiency of cystathionine b-synthase (CBS). The major clinical symptoms of this disease are mental retardation, lens dislocation, vascular disease with life-threatening thromboembolisms,... -
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- A novel way of therapeutic angiogenesis using an adeno-associated virus-mediated angiogenin gene transfer
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Cho YH, Park H, Cho ES, Kim WJ, Kang BS, Park BY, Kim YJ, Lee YI, Chang SI, Park K
- KMID: 1047093
- Exp Mol Med.
- 2007 Jun;39(3):412-418.
To develop a novel therapeutic angiogenesis for the treatment of cardiovascular diseases, angiogenin (ANG1) was examined as a potential therapeutic gene. An adeno-associated virus (AAV)-mediated gene delivery system was used... -
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- AAV-Mediated Astrocyte-Specific Gene Expression under Human ALDH1L1 Promoter in Mouse Thalamus
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Koh W, Park YM, Lee SE, Lee CJ
- KMID: 2398423
- Exp Neurobiol.
- 2017 Dec;26(6):350-361.
- doi: 10.5607/en.2017.26.6.350
Adeno-associated virus (AAV)-mediated gene delivery has been proposed to be an essential tool of gene therapy for various brain diseases. Among several cell types in the brain, astrocyte has become... -
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- Gene Therapy of Inherited Muscle Diseases
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Shin JH
- KMID: 1492122
- J Korean Soc Clin Neurophysiol.
- 2012 Dec;14(2):53-58.
For the last decades, molecular genetics has achieved great advances that the genes on the list of inherited muscle diseases are piling up. Those diseases of overlapping clinico-pathologic findings are... -
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- Simple Purification of Adeno-Associated Virus-DJ for Liver-Specific Gene Expression
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Liu J, Moon YA
- KMID: 2374103
- Yonsei Med J.
- 2016 May;57(3):790-794.
- doi: 10.3349/ymj.2016.57.3.790
Recombinant gene expression using adeno-associated viruses (AAVs) has become a valuable tool in animal studies, as they mediate safe expression of transduced genes for several months. The liver is a... -
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- Recombinant AAV Vector with MITF-M Promoter for Melanoma Gene Therapy
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Park SW, Paik SY
- KMID: 1434773
- J Bacteriol Virol.
- 2012 Mar;42(1):57-62.
- doi: 10.4167/jbv.2012.42.1.57
We have developed the recombinant adeno-associated virus (AAV) carrying the EGFP gene under the control of the microphtalmia-associated transcription factor-M (MITF-M) promoter region for melanoma-specific expression. MITF-M distal enhancer (MDE)... -
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- Differential Cellular Tropism of Lentivirus and Adeno-Associated Virus in the Brain of Cynomolgus Monkey
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An H, Cho DW, Lee SE, Yang YS, Han SC, Lee CJ
- KMID: 2165578
- Exp Neurobiol.
- 2016 Feb;25(1):48-54.
- doi: 10.5607/en.2016.25.1.48
Many researchers are using viruses to deliver genes of interest into the brains of laboratory animals. However, certain target brain cells are not easily infected by viruses. Moreover, the differential... -
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- Development of Trans Attack Anticancer Gene Vaccine Interact in HPV Oncoprotein Expression Inhibition
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Lee HJ, Lee SH, Kim HJ, Kim JH, Lew YO, Lee JO, Kim YW, Ahn WS, Kim CK, Lee JM, Kim DH, Namkoong S, Kang KD
- KMID: 2272267
- Korean J Obstet Gynecol.
- 2004 Feb;47(2):258-263.
OBJECTIVE: Adeno-associated virus Rep 78 protein is known to inhibit the promoter site of several onco-genes and viral gene, including the human papillomavirus type 16 E6 transforming genes. In this... -
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- Detection of Adeno-associated Virus from Semen Suffering with Male Factor Infertility and Having Their Conception Partners with Recurrent Miscarriages
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Kim CH, Kim JH, Kim HJ, Kim KW, Lee JY, Yang SH, Choe J, Hwang D, Kim KC, Hwang ES
- KMID: 2168669
- J Bacteriol Virol.
- 2012 Dec;42(4):339-345.
- doi: 10.4167/jbv.2012.42.4.339
Adeno-associated virus (AAV) and human papillomavirus (HPV) DNAs were found in abnormal quality semen, early abortus and female genital tissues. It was suggested that they might cause male infertility and... -
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- Construction of Recombinant Adeno-Associated Virus Vector (AAVCMVp53) for Human Cervical Cancer Gene Therapy
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Kim YW, Seo MJ, Bae SM, Jun JK, Kim TH, Jin TY, Lee SW, Kim YW, Kim CK, Lee JM, Namkoong S, Ahn WS
- KMID: 2272307
- Korean J Obstet Gynecol.
- 2004 Apr;47(4):695-701.
OBJECTIVE: To eliminate the potential problem of adenovirus contamination during recombinant adeno-associated virus (rAAV) vector production, we investigated new rAAV production method by a triple transfection of vector plasmid, packaging... -
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- Neuronal Expression and Cell-Type-Specific Gene-Silencing of Best1 in Thalamic Reticular Nucleus Neurons Using pSico-Red System
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Jung JY, Lee SE, Hwang EM, Lee CJ
- KMID: 2308637
- Exp Neurobiol.
- 2016 Jun;25(3):120-129.
- doi: 10.5607/en.2016.25.3.120
Assessing the cell-type expression pattern of a certain gene can be achieved by using cell-type-specific gene manipulation. Recently, cre-recombinase-dependent gene-silencing tool, pSico has become popular in neuroscientific research. However, pSico... -
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- Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2
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Yun HJ, Cho YH, Moon Y, Park YW, Yoon HK, Kim YJ, Cho SH, Lee YI, Kang BS, Kim WJ, Park K, Seo W
- KMID: 756337
- Exp Mol Med.
- 2008 Jun;40(3):345-353.
- doi: 10.3858/emm.2008.40.3.345
For cancer gene therapy, cancer-specific over-expression of a therapeutic gene is required to reduce side effects derived from expression of the gene in normal cells. To develop such an expression... -
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- Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients
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Park KJ, Lee J, Park JH, Joh JW, Kwon CH, Kim JW
- KMID: 2373578
- Ann Lab Med.
- 2016 Sep;36(5):469-474.
- doi: 10.3343/alm.2016.36.5.469
BACKGROUND: The incidence and etiology of hepatocellular carcinoma (HCC) vary widely according to race and geographic regions. The insertional mutagenesis of adeno-associated virus 2 (AAV2) has recently been considered a... -
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- Relationship Between Adeno-Associated Virus and High Risk Human Papilloma Viruses in Cervical Biopsies Using Microdissection Technique
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Chung JE, Ro DY, Bae JH, Jin DK, Lee SH, Ko HS, Bae SM, Lee HK, Kim BK, Kim CK, Lee JM, Namkoong S, Ahn WS
- KMID: 2271975
- Korean J Obstet Gynecol.
- 2003 Feb;46(2):429-434.
OBJECTIVE: Adeno associated virus (AAV) is a human DNA virus and is included in the Parvovirus family. AAV has been detected in cervical tissues as well as cervical cancer cell... -
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- Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration
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Chung JH, Im EK, Jin T, Lee SM, Kim SH, Choi EY, Shin MJ, Lee KH, Jang Y
- KMID: 1104387
- Exp Mol Med.
- 2011 Apr;43(4):179-188.
- doi: 10.3858/emm.2011.43.4.022
Gene transfer of basic fibroblast growth factor (bFGF) has been shown to induce significant endothelial migration and angiogenesis in ischemic disease models. Here, we investigate what factors are secreted from... -
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- Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo
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Kim S, Moon GJ, Oh YS, Park J, Shin WH, Jeong JY, Choi KS, Jin BK, Kholodilov N, Burke RE, Kim HJ, Ha CM, Lee SG, Kim SR
- KMID: 2440022
- Exp Mol Med.
- 2018 Feb;50(2):e440.
- doi: 10.1038/emm.2017.261
We recently reported that adeno-associated virus serotype 1 (AAV1) transduction of murine nigral dopaminergic (DA) neurons with constitutively active ras homolog enriched in brain with a mutation of serine to... -
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