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The effect of deferoxamine on the preneoplastic lesions in the chemically induced hepatocarcinogenesis

Park YN, Jung WH, Park C

Iron is essential for the growth of all living cells. One of the most important intracellular roles of iron is the activation of ribonucleotide reductase, which is indispensible to the...
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Iron chelator inducesMIP-3alpha/CCL20 in human intestinal epithelial cells: implication for triggeringmucosal adaptive immunity

Lee HJ, Choi SC, Choi EY, Lee MH, Seo GS, Kim EC, Yang BJ, Lee MS, Shin YI, Park KI, Jun CD

  • KMID: 1093465
  • Exp Mol Med.
  • 2005 Aug;37(4):297-310.
A previous report by this laboratory demonstrated that bacterial iron chelator (siderophore) triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs). Microarray-based gene...
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Effect of anticancer drugs and desferrioxamine in combination with radiation on hepatoma cell lines

Kim WH, Chon CY, Moon YM, Kang JK, Park IS, Choi HJ

Several anticancer chemotherapeutic agents (5-fluorouracil, adriamycin and cisplatinum) and desferrioxamine, an iron chelator, were tested with regard to cytotoxicity and to the combined effect on radiation induced cell killing using...
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The mechanism of antiproliferative effect of desferrioxamine on human hepatoma cell lines

Kim DY, Kim WH, Kang JK, Park IS, Kwon OH

We investigated the effect of desferrioxamine (DFO), an iron chelator, on the DNA synthesis and the cell cycle of cultured hepatoma cells. Using Hep 3B cells as the hepatoma cell...
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