- Possible Roles of UL112-113 Proteins in Human Cytomegalovirus DNA Replication
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Kim YE, Ahn JH
- KMID: 1717687
- J Bacteriol Virol.
- 2012 Jun;42(2):162-168.
- doi: 10.4167/jbv.2012.42.2.162
DNA replication of human cytomegalovirus (HCMV) is a highly regulated process that requires specific interactions between cis-acting lytic origin of replication (oriLyt) and trans-acting viral proteins. Formation of the replication... -
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- Genome Architecture and Its Roles in Human Copy Number Variation
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Chen L, Zhou W, Zhang L, Zhang F
- KMID: 2391488
- Genomics Inform.
- 2014 Dec;12(4):136-144.
- doi: 10.5808/GI.2014.12.4.136
Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic... -
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- Cell cycle checkpoint control
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Murakami H, Okayama H
- KMID: 2128619
- Exp Mol Med.
- 1997 Mar;29(1):1-11.
Genetic instability is considered to be a major driving force of malignancy of cancer cells, and at least some of cancer-associated genetic instability is known to be caused by defects... -
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- Kidneys with bad ends
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Suh D
- KMID: 2322081
- J Korean Soc Pediatr Nephrol.
- 2008 Apr;12(1):11-22.
Telomeres consist of tandem guanine-thymine(G-T) repeats in most eukaryotic chromosomes. Human telomeres are predominantly linear, double stranded DNA as they ended in 30-200 nucleotides(bases,b) 3'-overhangs. In DNA replication, removal of... -
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- The Change of HBV DNA Titer after Hepatic Resection in Hepatitis B Patients with Hepatocelluar Carcinoma
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Lee HW, Suh KS, Kim J, Shin WY, Yi NJ, Lee KU
- KMID: 1920804
- Korean J Hepatobiliary Pancreat Surg.
- 2010 Mar;14(1):16-24.
PURPOSE: Reactivation of hepatitis B virus (HBV) replication after hepatic resection might be a significant risk factor for prognosis in patients with chronic hepatitis B. The purpose of the present... -
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- The Effect of Genetic Variation in The Dna Base Repair Genes on the Risk of Head and Neck Cancer
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Oh JH, Yoon BW, Choi BJ
- KMID: 2005382
- J Korean Assoc Oral Maxillofac Surg.
- 2008 Oct;34(5):509-517.
DNA damage accumulates in cells as a result of exposure to exogenous agents such as benzopyrene, cigarette smoke, ultraviolet light, X-ray, and endogenous chemicals including reactive oxygen species produced from... -
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- Proliferating Cell Nuclear Antigen Labelling Index in Gastric Cancer and Its Significances
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Kim YJ, Kuh WH, Kim DY, Kim SK, Park CS
- KMID: 2128648
- Korean J Gastroenterol.
- 1998 Mar;31(3):302-308.
BACKGROUND AND AIMS: Proliferating cell nuclear antigen (PCNA) is an auxillary protein of DNA polymerase delta and is tightly associated with sites of DNA replication. We studied the expression of... -
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- Telomerase Activity in Gastric Adenocarcinomas: Frozen Tissues Versus Methacarn-fixed Paraffin-embedded Tissues
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Yoo J, Kang SJ, Kang CS
- KMID: 1972867
- Cancer Res Treat.
- 2003 Dec;35(6):478-482.
PURPOSE: Telomerase is an RNA-dependent DNA polymerase that synthesizes TTAGGG telomeric DNA onto chromosome ends to compensate for sequence loss during DNA replication. It has been detected in 85~90% of... -
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- Immunohistochemical characteristics of colorectal carcinoma with DNA replication errors
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Kim H, Jung JK, Park JH, Park C
- KMID: 644941
- J Korean Med Sci.
- 1996 Apr;11(2):137-143.
- doi: 10.3346/jkms.1996.11.2.137
It has recently been shown that nearly all cancers from hereditary nonpolyposis colorectal cancer syndrome (HNPCC), as well as a subset of sporadic colorectal cancers, have DNA replication errors (RER)... -
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- Reactivation of Hepatitis B Virus in Patients with Rheumatologic Disease Treated with Biologic Disease Modifying Anti-rheumatic Drugs: Screening and Treatment
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Lee JI
- KMID: 2222839
- J Rheum Dis.
- 2015 Oct;22(5):282-287.
- doi: 10.4078/jrd.2015.22.5.282
Reactivation of hepatitis B virus (HBV) is not infrequently reported in patients with rheumatologic diseases treated with biologic disease modify anti-rheumatic drugs (DMARDs) such as a tumor necrosis factor-alpha inhibitor... -
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- Comparative Analysis of the Three Classes of Archaeal and Bacterial Ribonucleotide Reductase from Evolutionary Perspective
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Pangare MG, Chandra SB
- KMID: 1806199
- Genomics Inform.
- 2010 Dec;8(4):170-176.
The Ribonucleotide reductases (RNR) are essential enzymes that catalyze the conversion of nucleotides to deoxynucleotides in DNA replication and repair in all living organisms. The RNRs operate by a free... -
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- Interactome Analysis Reveals that Heterochromatin Protein 1gamma (HP1gamma) Is Associated with the DNA Damage Response Pathway
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Kim H, Choi JD, Kim BG, Kang HC, Lee JS
- KMID: 2152291
- Cancer Res Treat.
- 2016 Jan;48(1):322-333.
- doi: 10.4143/crt.2014.294
PURPOSE: Heterochromatin protein 1gamma (HP1gamma) interacts with chromosomes by binding to lysine 9-methylated histone H3 or DNA/RNA. HP1gamma is involved in various biological processes. The purpose of this study is... -
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- Functional Link between DNA Damage Responses and Transcriptional Regulation by ATM in Response to a Histone Deacetylase Inhibitor TSA
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Lee JS
- KMID: 1522934
- Cancer Res Treat.
- 2007 Sep;39(3):116-124.
PURPOSE: Mutations in the ATM (ataxia-telangiectasia mutated) gene, which encodes a 370 kd protein with a kinase catalytic domain, predisposes people to cancers, and these mutations are also linked to... -
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- Possible Role of Single Stranded DNA Binding Protein 3 on Skin Hydration by Regulating Epidermal Differentiation
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Choi MR, Shin JM, Shin YA, Chang YH, Chang MY, Lim CA, Sohn KC, Seo YJ, Kim CD, Lee JH, Lee Y
- KMID: 2457520
- Ann Dermatol.
- 2018 Aug;30(4):432-440.
- doi: 10.5021/ad.2018.30.4.432
BACKGROUND: Skin hydration is a common problem both in elderly and young people as dry skin may cause irritation, dermatological disorders, and wrinkles. While both genetic and environmental factors seem... -
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- Fragile sites induced by aphidicolin in lymphocytes, HaCat cells and MRC-5 cells
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Park KR, Goo DE, Lee JH, Kim WS, Lee YH, Kwon OY, Chang SI
- KMID: 1937889
- Korean J Anat.
- 1998 Oct;31(5):785-790.
To investigate fragile sites induced by aphidicolin which is a specific inhibitor of eukaryotic DNA polymerase a which is primarily associated with chromosomal DNA replication in human lymphocytes, HaCat cells... -
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- Baller-Gerold Syndrome in a Premature Infant with a Mutation in the RECQL4 Gene
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Kim JS
- KMID: 2466646
- Neonatal Med.
- 2019 Nov;26(4):240-245.
- doi: 10.5385/nm.2019.26.4.240
Baller-Gerold syndrome is a rare autosomal recessive disorder characterized by premature fusion of the cranial sutures and malformation of the upper limb extremities at birth. Although the pathogenesis of Baller-Gerold... -
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- Proliferation Patterns of N-butyl-N- ( 4-hydroxybutyl ) Nitrosamine ( BBN ) Induced Rat Bladder Tumor Identified by Histone mRNA In Situ Hybridization
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Ryu CO, Seo JW, Kim YT, Kim WJ
- KMID: 1870526
- Korean J Urol.
- 1997 Feb;38(2):111-119.
The synthesis of histone mRNA is closely coupled with DNA replication. During the S-phase of the cell cycle, the level of histone mRNA increases over fifty fold then rapidly disappears... -
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- Telomerase Activity in Laryngeal Papilloma
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Kim CD, Sung MW, Hong SK, Kim KH
- KMID: 2141438
- Korean J Otolaryngol-Head Neck Surg.
- 1997 Oct;40(10):1384-1389.
BACKGROUND: Telomere is derived from Greek words, telos(end) and mere(part). While being located at the end of the chromosome, it contributes to its stability and not only prevents DNA rebonding... -
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- Prognostic Significance of Immunohistochemical MSH2 Expression in Prostate Cancer
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Kim YB, Lee DG, Yoo KH, Lee HL, Choi SK
- KMID: 2438595
- Korean J Urol Oncol.
- 2018 Aug;16(2):58-62.
- doi: 10.22465/kjuo.2018.16.2.58
PURPOSE: There are numerous prostate cancer-related genes that involve in carcinogenesis and tumor progression. Among the genes, DNA mismatch repair genes recognize and repair misincorporated nucleotides during DNA replication. In... -
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- Gene Expression Analysis of Galpha13-/- Knockout Mouse Embryos Reveals Perturbations in Galpha13 Signaling Related to Angiogenesis and Hypoxia
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Park JH, Choi S
- KMID: 2053272
- Genomics Inform.
- 2011 Dec;9(4):161-172.
Angiogenesis is regulated by a large number of molecules and complex signaling mechanisms. The G protein Galpha13 is a part of this signaling mechanism as an endothelial cell movement regulator.... -
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