- Ultraviolet light DNA repair and skin cancers identification of xeroderma pigmentosum D group correcting factor
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Kim J
- KMID: 1694369
- J Korean Cancer Assoc.
- 1993 Oct;25(5):696-706.
No abstract available. -
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- The Effect of Genetic Variation in The Dna Base Repair Genes on the Risk of Head and Neck Cancer
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Oh JH, Yoon BW, Choi BJ
- KMID: 2005382
- J Korean Assoc Oral Maxillofac Surg.
- 2008 Oct;34(5):509-517.
DNA damage accumulates in cells as a result of exposure to exogenous agents such as benzopyrene, cigarette smoke, ultraviolet light, X-ray, and endogenous chemicals including reactive oxygen species produced from... -
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- Aberrant DNA Double-strand Break Repair Threads in Breast Carcinoma: Orchestrating Genomic Insult Survival
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Kumar A, Purohit S, Sharma NK
- KMID: 2367559
- J Cancer Prev.
- 2016 Dec;21(4):227-234.
- doi: 10.15430/JCP.2016.21.4.227
Breast carcinoma is a heterogeneous disease that has exhibited rapid resistance to treatment in the last decade. Depending genotype and phenotype of breast cancer, there are discernible differences in DNA... -
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- The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)
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Seo YR, Jung HJ
- KMID: 1103316
- Exp Mol Med.
- 2004 Dec;36(6):505-509.
The p53 tumor suppressor has long been envisaged to preserve genetic stability by the induction of cell cycle checkpoints and apoptosis. More recently, p53 has been implicated to play roles... -
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- Relationship between Radiation Induced Activation of DNA Repair Genes and Radiation Induced Apoptosis in Human Cell Line A431
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Bom HS, Min JJ, Choi KH, Kim KK
- KMID: 2078705
- Korean J Nucl Med.
- 2000 Apr;34(2):144-153.
PURPOSE: The purpose of this study was to evaluate the relationship between radiation-induced activation of DNA repair genes and radiation induced apoptosis in A431 cell line. MATERALS AND METHODS: Five and 25... -
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- Tissue-specific Expression of DNA Repair Gene, N-Methylpurine-DNA Glycosylase (MPG) in Balb/c Mice without External Damage
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Kim NK
- KMID: 1538082
- J Genet Med.
- 1998 Mar;2(1):31-34.
The N-methylpurine-DNA glycosylase (MPG), a ubiquitous DNA repair enzyme, removes N-methylpurine and other damaged purines induced in DNA. Tissue-specific mRNA levels of the N-methylpurine-DNA glycosylase (MPG) were investigated in Balb/c... -
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- Study of UV DNA Repair Endonucleases with Respect to Skin Cancers
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Kim J, Nam YS, Park YI
- KMID: 2059124
- J Korean Cancer Assoc.
- 1997 Aug;29(4):599-607.
No abstract available -
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- Identification of Escherichia coli 8-oxoguanine endonuclease
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Lee YS, Chung MH
- KMID: 755080
- Exp Mol Med.
- 2000 Sep;32(3):155-160.
7,8-Dihydro-8-oxoguanine (oh8Gua) endonuclease is a DNA repair enzyme in Escherichia coli to remove oh8Gua, a promutagenic DNA adduct. Due to the unique mode of enzyme action and substrate specificity, this... -
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- Base excision repair synthesis of DNA containing 8-oxoguanine in Escherichia coli
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Lee YS, Chung MH
- KMID: 1097258
- Exp Mol Med.
- 2003 Apr;35(2):106-112.
8-oxo-7,8-dihydroguanine (8-oxo-G) in DNA is a mutagenic adduct formed by reactive oxygen species. In Escherichia coli, 2,6-dihydroxy-5N-formamidopyrimidine (Fapy)-DNA glycosylase (Fpg) removes this mutagenic adduct from DNA. In this report, we... -
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- DNA damage to human genetic disorders with neurodevelopmental defects
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Lee Y, Choi I, Kim J, Kim K
- KMID: 2327696
- J Genet Med.
- 2016 Jun;13(1):1-13.
- doi: 10.5734/JGM.2016.13.1.1
Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich... -
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- Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs
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Lee JH, Cheong HM, Kang MY, Kim SY, Kang Y
- KMID: 1982566
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):343-348.
- doi: 10.4196/kjpp.2009.13.5.343
53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage... -
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- Two Cases of Xeroderma Pigmentosum with Skin Cancer
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Lee JS, Kang HY, Lee ES, Kim YC
- KMID: 1590938
- Korean J Dermatol.
- 2005 Feb;43(2):233-238.
Xeroderma pigmentosum is a rare autosomal recessive disease associated with sun sensitivity, photophobia, early onset of freckling, and subsequent neoplastic changes to sun-exposed areas. The repair of ultraviolet-induced DNA damage... -
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- SIRT1 promotes DNA repair activity and deacetylation of Ku70
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Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM, Cho MH, Park GH, Lee KH
- KMID: 1103676
- Exp Mol Med.
- 2007 Feb;39(1):8-13.
Human SIRT1 controls various physiological responses including cell fate, stress, and aging, through deacetylation of its specific substrate protein. In processing DNA damage signaling, SIRT1 attenuates a cellular apoptotic response... -
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- Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention
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Yildiz A, Kaya Y, Tanriverdi O
- KMID: 2468796
- J Cancer Prev.
- 2019 Sep;24(3):146-154.
- doi: 10.15430/JCP.2019.24.3.146
Cancer is the most common cause of death worldwide. Annually, more than ten million new cancer cases are diagnosed, and more than six million deaths occur due to cancer. Nonetheless,... -
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- Inhibition of DNA-dependent Protein Kinase by Blocking Interaction between Ku Complex and Catalytic Subunit of DNA-dependent Protein Kinase
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Kim CH, Cuong DV, Kim JS, Kim N, Kim E, Han J
- KMID: 1607348
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):9-14.
Recent studies indicated that cancer cells become resistant to ionizing radiation (IR) and chemotherapy drugs by enhanced DNA repair of the lesions. Therefore, it is expected to increase the killing... -
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- Non-homologous End Joining Inhibitor SCR-7 to Exacerbate Low-dose Doxorubicin Cytotoxicity in HeLa Cells
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Kumar A, Bhatkar D, Jahagirdar D, Sharma NK
- KMID: 2375548
- J Cancer Prev.
- 2017 Mar;22(1):47-54.
- doi: 10.15430/JCP.2017.22.1.47
Among the genotoxic drug regimens, doxorubicin (DOX) is known for its high-dose side effects in several carcinomas, including cervical cancer. This study reports on testing the combined use of a... -
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- Cytosine Arabinoside-Induced PC12 Cell Death Pathway
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Yang BG, Chai YG, Yang BH
- KMID: 2334571
- J Korean Soc Biol Psychiatry.
- 1998 Nov;5(2):219-226.
Cytosine arabinoside(AraC) inhibits DNA synthesis and beta-DNA polymerase, an enzyme involved in DNA repair. This a potent antimitotic agent, is clinically used as an anticancer drug with side effect of... -
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- Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells
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Wan J, Bae MA, Song BJ
- KMID: 755668
- Exp Mol Med.
- 2004 Feb;36(1):71-77.
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify... -
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- Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
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Lin SY, Liang Y, Li K
- KMID: 1074978
- Yonsei Med J.
- 2010 May;51(3):295-301.
- doi: 10.3349/ymj.2010.51.3.295
Mammalian cells are frequently at risk of DNA damage from both endogenous and exogenous sources. Accordingly, cells have evolved the DNA damage response (DDR) pathways to monitor and assure the... -
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- Methylation Pattern of DNA Repair Genes and Microsatellite Instability in Hepatocelluar Carcinoma
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Park JH, Cho SB, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Lee JH, Kim SJ
- KMID: 1113480
- Korean J Gastroenterol.
- 2006 Nov;48(5):327-336.
BACKGROUND/AIMS: Epigenetic silencing of DNA repair genes, O6-methylguanine-DNA methyltransferase (MGMT), hMLH1 and hMSH3, by promoter hypermethylation have been observed in various cancers. However, the relationship between hypermethylation of DNA... -
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