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Adenovirus-Mediated Toxic Gene Therapy Using Cytosine Deaminase and Osteocalcin Promoter for the Treatment of Prostate Cancer

Park HS, Bae JH, Moon DG, Cho HY, Kao C, Gardner TA, Cheon J

  • KMID: 1583951
  • Korean J Urol.
  • 2000 Dec;41(12):1437-1444.
No abstract available.
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Enhancement of Bystander Prostate Cancer Cell Killing by the Utilization of Bone Marrow Stromal Cells Genetically Engineered to Express Cytosine Deaminase

Kim SJ, Gardner TA, Ko SC, Kao C, Chung LW

  • KMID: 1583473
  • Korean J Urol.
  • 2000 Aug;41(8):933-939.
No abstract available.
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Tumor targeted gene therapy

Kang JH

  • KMID: 1512522
  • Nucl Med Mol Imaging.
  • 2006 Oct;40(5):237-242.
Knowledge of molecular mechanisms governing malignant transformation brings new opportunities for therapeutic intervention against cancer using novel approaches. One of them is gene therapy based on the transfer of genetic...
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Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine

Lee H, Ryu J, Kim KA, Lee KS, Lee JY, Park JB, Park J, Choi SY

  • KMID: 755664
  • Exp Mol Med.
  • 2004 Feb;36(1):43-51.
Enzyme/prodrug approach is one of the actively developing areas for cancer therapy. In an effort to develop more effective enzyme/prodrug systems, cell-permeable cytosine deaminase was produced by fusing yeast cytosine...
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Suicide Gene Therapy for Bladder Cancer Using a Recombinant Adenovirus Expressing Escherichia Coli Cytosine Deaminase

Ahn M, Lim HY, Kao C, Gardner TA, Ko SC, Kim SJ

  • KMID: 1990951
  • Korean J Urol.
  • 2003 Mar;44(3):244-249.
PURPOSE: The poor prognosis of advanced bladder cancer requires the investigation of novel treatment modalities. In this study, we investigated the suicide gene therapy for bladder cancer, using the adenovirus-mediated...
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Selective Delivery of a Therapeutic Gene for Treatment of Head and Neck Squamous Cell Carcinoma Using Human Neural Stem Cells

Kwon SK, Kim SU, Song JJ, Cho CG, Park SW

  • KMID: 2468440
  • Clin Exp Otorhinolaryngol.
  • 2013 Sep;6(3):176-183.
OBJECTIVES: Based on studies of the extensive tropism of neural stem cells (NSCs) toward malignant brain tumor, we hypothesized that NSCs could also target head and neck squamous cell carcinoma...
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A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models

Heo JR, Hwang KA, Kim SU, Choi KC

PURPOSE: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into...
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Retrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells

Park JS, Chang DY, Kim JH, Jung JH, Park J, Kim SH, Lee YD, Kim SS, Suh-Kim H

  • KMID: 2154229
  • Exp Mol Med.
  • 2013 Feb;45(2):e10.
Human mesenchymal stem cells (MSCs) have emerged as attractive cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases; this is, in part, because they have the capability...
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The Transfection of Cytosine Deaminase Gene and the Cell Killing Effects of Administration of 5-Fluorocytosine in Colon Cancer Cell Lines

Cha SW, Chang SK

  • KMID: 1896294
  • J Korean Surg Soc.
  • 2004 Apr;66(4):271-280.
PURPOSE: Among cancer gene therapies, the aims to eliminate malignant cells using genes as drugs as substitutes for conventional therapy, the use of bacterial cytosine deaminase (CD) which can convert...
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Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node–Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models

Park GT, Kim SU, Choi KC

PURPOSE: Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, genetically engineered human neural stem cells...
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