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Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

Kim YS, Joh TH

  • KMID: 1110117
  • Exp Mol Med.
  • 2006 Aug;38(4):333-347.
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's...
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Resistance to Toxoplasma gondii Infection in Mice Treated with Silk Protein by Enhanced Immune Responses

Moon JH, Pyo KH, Jung BK, Chun HS, Chai JY, Shin EH

This study investigated whether elevated host immune capacity can inhibit T. gondii infection. For this purpose, we used silk protein extracted from Bombyx mori cocoons as a natural supplement to...
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Immune Responses of NIH Mice Infected with Avirulent and Virulent Strains of Plasmodium chabaudi adami Single and Mixed Infections

Namazi MJ, Phillips R

An understanding of the nature of the immune response to asexual erythrocytic stages of malaria parasites will facilitate vaccine development by identifying which responses the vaccine should preferentially induce. The...
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TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling

Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M

PURPOSE: Tripartite-motif-containing protein 56 (TRIM56) has been found to exhibit a broad antiviral activity, depending upon E3 ligase activity. Here, we attempted to evaluate the function of TRIM56 in multiple...
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Immune Responses of Mice Intraduodenally Infected with Toxoplasma gondii KI-1 Tachyzoites

Shin EH, Chun YS, Kim WH, Kim JL, Pyo KH, Chai JY

Toxoplasma gondii Korean isolate (KI-1) tachyzoites were inoculated intraduodenally to BALB/c mice using a silicon tube, and the course of infection and immune responses of mice were studied. Whereas control...
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Parasitic Helminth Cystatin Inhibits DSS-Induced Intestinal Inflammation Via IL-10+F4/80+ Macrophage Recruitment

Jang SW, Cho MK, Park MK, Kang SA, Na BK, Ahn SC, Kim DH, Yu HS

Many immune down-regulatory molecules have been isolated from parasites, including cystatin (cystain protease inhibitor). In a previous study, we isolated and characterized Type I cystatin (CsStefin-1) of the liver fluke,...
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