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Expression of NF-kappaB and Cytokines in Chronic Rejection of Transplanted Murine Heart

Lee JR, Seok CJ, Kim JS, Chang JM, Seo JW

The heart transplantation-associated accelerated graft arteriosclerosis (AGAS) is one of the major causes of cardiac allograft failure. We investigated the early time-course of expresssion patterns of cytokines, transcription factor, and...
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Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells

Jung HW, Chung YS, Kim YS, Park YK

  • KMID: 1091066
  • Exp Mol Med.
  • 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as...
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CD137 induces adhesion and cytokine production in human monocytic THP-1 cells

Choi JW, Lee HW, Roh GS, Kim HH, Kwack KB

  • KMID: 755745
  • Exp Mol Med.
  • 2005 Apr;37(2):78-85.
CD137, which is expressed on activated T cells, plays a critical role in inflammatory responses. However, the exact role that CD137 plays in monocytes is not fully known. Here we...
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Changes of cytokine mRNA expression and IgG responses in rats infected with Capillaria hepatica

Kim DK, Joo KH, Chung MS

The mRNA expression of several cytokines was evaluated in splenocytes and mesenteric lymph node (MLN) cells of rats infected with Capillaria hepatica by reverse-transcription (RT)-PCR until week 12 after infection....
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Cytokine Production by Whole Blood Cells: Relationship to Interleukin Gene Polymorphism and Bone Mass

Kim JG, Ku SY, Lim KS, Jee BC, Suh CS, Kim SH, Choi YM, Moon SY

The aims of this study were to investigate the relationships between the production of interleukin-1 (IL-1), and IL-6 system by whole blood cells, and bone mineral density (BMD), and polymorphisms...
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Suppressed Production of Pro-inflammatory Cytokines by LPS-Activated Macrophages after Treatment with Toxoplasma gondii Lysate

Lee EJ, Heo YM, Choi JH, Song HO, Ryu JS, Ahn MH

During Toxoplasma gondii infection, macrophages, dendritic cells, and neutrophils are important sources of pro-inflammatory cytokines from the host. To counteract the pro-inflammatory activities, T. gondii is known to have several...
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Cytokine and antibody responses of reactivated murine toxoplasmosis upon administration of dexamathasone

Kang KN, Choi IU, Shin DW, Lee YH

Toxoplasma gondii has been shown to result in life-threatening encephalitis in immunocompromised patients after reactivation of dormant parasites. In order to obtain information on immune responses related to this phenomenon,...
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Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production

Lee SJ, Namkoong S, Ha KS, Nam WD, Kwon YG, Lee H, Yoon EY, Chang DJ, Kim SO, Kim YM

  • KMID: 1094664
  • Exp Mol Med.
  • 2007 Apr;39(2):230-238.
Colchicine has been shown to regulate the expression of inflammatory gene, but this compound possesses much weaker anti-inflammatory activity. In this study, we synthesized a new colchicine derivative CT20126 and...
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Effects of Benzo[a]pyrene, 2-Bromopropane, Phenol and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Proinflammatory Cytokines Gene Expression by Mice Spleen Cells

Kim HJ, Kang BN, Cho SW, Son HY, Jeong KS, Park SJ, Kim SH, Kim SR, Kim TH, An MY, Ryu SY

  • KMID: 1097340
  • J Vet Sci.
  • 2002 Dec;3(4):247-254.
The detrimental effects of environmental pollutants on the health of the individual are generally accepted, although the mechanisms of these effects remain to be incompletely understood. In the present study,...
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Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema

Gamze K, Mehmet HM, Deveci F, Turgut T, ilhan F, Ozercan I

  • KMID: 1090964
  • Exp Mol Med.
  • 2007 Oct;39(5):614-620.
Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to...
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Cytokine response in Balb/c mice infected with Francisella tularensis LVS and the Pohang isolate

Kim EJ, Park SH, Choi YS, Shim SK, Park MY, Park MS, Hwang KJ

We investigated the immune response induced by the Francisella (F.) tularensis live vaccine strain (LVS) and the Pohang isolate. After the Balb/c mice were infected intradermally (i.d) with 2 x...
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Induction of apoptotic lesions in liver and lymphoid tissues and modulation of cytokine mRNA expression by acute exposure to deoxynivalenol in piglets

Mikami O, Yamaguchi , Murata H, Nakajima Y, Miyazaki S

Six 1-month-old piglets were intravenously injected with deoxynivalenol (DON) at the concentration of 1 mg/kg body weight, with three pigs each necropsied at 6 and 24 h post-injection (PI) for...
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