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Cytochrome P-450 Dependent N-and Ring-Hydroxylation of AAF of Various Fish Liver Compare with Rat Liver

Hong YS

No abstract available.
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Hepatic Microsomal Cytochrome P-450 Levels During Preimplatation in Rats

Ham YA, Kim SR, Hong YS, Sung NE

The levels of hepatic microsomal cytochrome P-450 in preimplantation rats were determined 1) The activities of the hepatic microsomal cytochrome P-450 associated with the events leading to implantation were gradually...
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Influence of Diazepam, Cimetidine and Sulpiride on the Level of Hepatic Microsomal Cytochrome P-450 in Rats

Kim BH, Ham YA, Hong YS, Sung NE

Cytochrome P-450 is a terminal oxidase of the hepatic microsomal monooxygenase system associated with the oxidative biotransformation of a varity of lipophilic endogenous and exogenous compounds, and generally is assayed...
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Effects of Xenoestrogens on Gene Expression of Cytochrome P450 Genes in in vitro Cultured Mice Spermatogenic Cells

Lee HJ, Kim MK, Ko DS, Kim KS, Kang HK, Kim DH

  • KMID: 1891262
  • Korean J Fertil Steril.
  • 2001 Jun;28(2):131-140.
No abstract available.
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The Effects of Vitamin Antioxidants on Lipid Peroxidation in Rat Liver Microsomes

Ham YA, Hong YS, Sung NE

We observed the effect of the administration of vitamin A,C and E with beta-naphthoflavone and piperonyl butoxide on cytochrome P-450 level and lipid peroxidation in rats liver. The level of...
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The Effects of Vitamin A and E on Lipid Peroxidation in Ethanol Administered Rat Liver Microsomes

Hong YS, Ham YA, Sung NE

Ethanol enhances the activity of microsomal enzyme system and lipid peroxidation. We observed the effect of chronic ethanol administration on cytochrome P-450 level and lipid peroxidation in rat liver microsome....
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Effect of Estrous Cycle and Preimplantation on Hepatic Microsomal Cytochrome P-450 Levels in Mice

Ham YA, Kim SR, Hong YS, Sung NE

Cytochrome P-450 is sometimes called the microsomal carbon monoxide-binding pigment. It is present in the microsomal fraction of several animal tissues, and also in the mitochondrial fraction of adrenal cortex,...
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The Effect of BHA and BHT on Mixed Function Oxygenase of Liver Tissue

Sung NE

To evaluate the effect of BHA and BHT on liver tissue, BHA and BHT, 100mg and 200mg/kg B.W. respectively, were given to experimental animals for 4 months. Microsomal cytochrome P-450, cytochrome...
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Inhibitory Effects of 6-Gingerol on Cytochrome P450 in Human Liver Microsomes

Joo SY, Lim YC

  • KMID: 2334469
  • J Korean Soc Clin Pharmacol Ther.
  • 2011 Jun;19(1):52-58.
No abstract available.
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Effect of Hydrocortisone on Cytochrome P-450 Apoproteins in Bile Duct Ligated and Adrenalectomized Rats

Lee MS

This study is concerned with cytochrome P-450 contents and different forms of cytochrome P-450 after administration of hydrocortisone in common bile duct ligated and adrenalectomized rats. Content of total hepatic...
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Inhibition of Carcinogenic Effects of N-Hydroxy-e-acetylaminofluorene by Vitamin Antioxidants

Sung NE, Hong YS

The principal role of cytochrome P-450 in many other mixed function oxidase reactions including hydroxylations or oxidative dealkylations of various drugs, fatty acids, steroids, pesticides, and carcinogens. In order to...
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Effect of Thiamine Deficiency on Drug Hydroxylation and Level of Cytochrome P-450 in the Rats

Kim BH, Hong YS, Sung NE

Our studies are concerned with cytochrome P-450 content and 2-acetylaminofluorene N-and ring-hydroxylation by thiamine deficient rat liver microsomes. Incubation medium contained 100mM HEPES buffer pH 7.8, 2mM NADPH, 100mM KF,...
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Effects of Exogenous Cholic Acid on Total Hepatic Cytochrome P-450 and b5 in the Bile Duct-ligated Rats

Choi KJ, Hong YS, Sung NE

We have investigated the effect of administation of exogenous cholic acid whether total hepatic cytochrome P-450 and b5 are altered in the bile duct-ligated rats. The effect of administration of exogenous...
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Studies on the Hepatic Microsomal Mixed Function Oxidase System with Higenamine on the Rat

Hong YS, Pae YS, Sung NE

The effect of intraperitonelly administered higenamine on the cytochrome P -450, b5, P-nitroanisole-O-demethylase and lipid peroxidation in the rat hepatic microsomes were determined. The following results were obtained ; 1)...
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A Study for The Effects of UV exposure and UV Exposure After Being Applied by Sunscreens on Hepatic Microsomal Cytochrome Enzyme System and Vitamin D in Newborn Rats

Ryu KO, Kook HI, Seong NE

  • KMID: 2146622
  • Korean J Dermatol.
  • 1986 Apr;24(2):205-212.
We observe changes of activation of hepatic microsomal cytochrome p-450, changes of formation of riug-and N-hydroxylation of 2-acetylaminofluorene, and changes of vitamin D, in the liver which exposed to UV...
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Effect of Nifedipine on Induction of Cytochrome P-450 1A1 and 2B1 in Spontaneously Hypertensive Rate

Hong YS, Kim HL, Park HY, Pae YS, Park SS

Cytochrome P-450(CYP) enzymes are important in catalyzing the hiotransffrmation on manyendogeneous compounds and xenobiotics, including drugs and carcinogens. In the presentstudy, effect of nifedipine a voltage dependent calcium channel blocker...
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CYP3A5*3 Polymorphism and Its Clinical Implications and Pharmacokinetic Role

Park JY, Cha YJ, Kim KA

  • KMID: 2317850
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):3-7.
The cytochrome P450 (CYP) 3A subfamily is estimated to participate in the biotransformation of 50% of the currently prescribed drugs. Four members of the CYP3A subfamily have been identified in...
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The Effect of Vitamin A and alpha-Tocopherol on Hydroxylation of AAF in the Young Rat Liver Microsome

Sook HY, Suk ST, Eung SN

The principal role of cytochrome p-450 in mixed function oxidase reactions includes hydroxylation of vavious drugs, fatty acids, steroids, pesticides, and carcinogens. The effect of AAF, beta-NF with vitamin A,...
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The Effects of Phototherapy Lights on the Cytochorme Enzyme System and Riboflavin Status in the Newborn Rats

Lee SJ

The effectiveness of phototherapy in the treatment of neonatal hyperbilirubinemia is so established that it is widely used without serious side effects. The widespread use of phototherapy has caused some...
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Clozapine-Induced Acute Hepatitis

Jang SJ, Yi HT, Paek JH, Lee SY

  • KMID: 2340279
  • J Korean Neuropsychiatr Assoc.
  • 1999 Jan;38(1):227-233.
The authors report two cases of clozapine-induced acute hepatitis. Two patients developed asymptomatic hepatitis and got better with conservative care. We decreased the dosage of clozapine and added hepatic protectors,...
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