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Expression of Cyclooxygenase-1 and -2 in Synovial Tissues from Patients with Rheumatoid Arthritis

Lee YH, Choi SJ, Ji JD, Kim A, Kim CH, Song GG

  • KMID: 2142255
  • J Korean Rheum Assoc.
  • 1998 Nov;5(2):159-168.
No abstract available.
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Expression of cyclooxygenase-1, -2 in human uterine cervix during gestational period

Oh JH, Kim HS, Yang JI, Kim MS, Yang SC, Han GS, Keum SS, Oh GS

  • KMID: 2262123
  • Korean J Obstet Gynecol.
  • 2000 Nov;43(11):2014-2019.
OBJECTIVE: To determine whether cyclooxygenase (COX)-1 and COX-2 are expressed differentially during the whole gestational period in the pregnant human uterine cervix and if they are involved in the process...
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Analgesic and Anti-inflammatory Effects of Ibuprofen, Indomethacin and NS-398 on an Acute Model of Arthritis in Rats

Kim NJ, Park JY, Han HC, Chang SH

BACKGROUND: All currently available nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 and cyclooxygenase-2 and exhibit many complications. It has been suggested that the anti-inflammatory and also most of...
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Peripheral Analgesic and Anti-inflammatory Effects of Diclofenac, SC-560 and NS-398 on Acute Arthritic Model in Rats

Park HS, Park JY, Han HC, Lim HJ, Chang SH, Yoon SM

BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are generally attributed to suppression cyclooxygenase enzymes, leading to decreased products of the arachidonic acid cascade. Since the discovery of two isoenzymes of cyclooxygenase, inhibition...
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Expression of Cyclooxygenase-1, -2 in Human Uterine Cervix of Preterm and Term Pregnancies

Kim HS, Kim MS, Yang HW, Yang JI, Ahn EJ, Oh KS

  • KMID: 2075714
  • Korean J Obstet Gynecol.
  • 1999 Apr;42(4):784-789.
OBJECTIVE: The purpose of this study was to determine whether cyclooxygenase [COX]-1 and COX-2 are expressed in the pregnant human uterine cervix and if they are expressed differentially between preterm...
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Nitric Oxide Donor, NOR-3, Increased Expression of Cyclooxygenase-2, but not of Cyclooxygenase-1 in Cultured VSMC

Lee DH, Park JE, Kang YJ, Lee KY, Choi HC

  • KMID: 2285328
  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):161-165.
NO and cyclooxygenase-2 (COX-2) are contributes to vascular inflammation induced by various stimulation. The mechanism, which explains a linkage between NO and COX-2, could be of importance in promoting pathophysiological...
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Melittin-induced Nociceptive Responses are Alleviated by Cyclooxygenase-1 Inhibitor

Kim J, Shin HK, Lee KH

  • KMID: 1512941
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):45-50.
Melittin-induced pain model has been known to be very useful for the study of pain mechanism. Melittin-induced nociceptive responses are reported to be modulated by the changes in the activity...
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Effects of Armeniacae Semen and Amygdalin on the Lipopolysaccaride-induced Prostaglandin E2 Synthesis and Nitric Oxide Production in Mouse BV2 Microglial Cells

Jung HJ, Kim YS, Shin MS, Kim CJ, Kim YS

Armeniacae semen has been used in traditional medicine for the treatment of pain and inflammatory diseases. Amygdalin is the major compound of Armeniacae semen, and it is used for treatment...
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Inhibitory Effects of Epigallocatechin-3-Gallate on Microsomal Cyclooxygenase-1 Activity in Platelets

Lee DH, Kim YJ, Kim HH, Cho HJ, Ryu JH, Rhee MH, Park HJ

  • KMID: 2170686
  • Biomol Ther.
  • 2013 Jan;21(1):54-59.
In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea catechins from green tea leaves, on activities of cyclooxygenase (COX)-1 and thromboxane synthase (TXAS),...
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Cyclic Expression of Cyclooxygenase-1 and -2 in Human Endometrium

Park DW, Yang HW, Kwon HC, Hwang KJ, Yoo JY, Lee CH, Kim SK, Cho DJ, Oh KS

  • KMID: 2085101
  • Korean J Fertil Steril.
  • 1998 Apr;25(1):25-33.
Cyclooxygenase (COX) is an enzyme involved in the conversion of arachidonic acid to prostaglandins(PGs), and exists in two forms, COX-1 and COX-2. COX has been reported to be involved in...
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3-Dimensional Culture System of Endometrial Cells for Studying the Human Implantation Mechanism

Park DW, Yang HW, Kwon HC, Chang KH, Kim SK, Cho DJ, Oh KS

  • KMID: 2085112
  • Korean J Fertil Steril.
  • 1999 Apr;26(1):1-8.
In order to study the implantation mechanism various methods for culture of endometrial cells in vitro have been attempted. However, a disadvantage is that primary cultures of stromal and epithelial...
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Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway

Shin S, Joo SS, Park D, Jeon JH, Kim TK, Kim JS, Park SK, Hwang BY, Kim YB

The anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG) were investigated in vitro and in vivo using croton oil-induced inflammation models. Croton oil (20 microgram/mL) up-regulated mRNA expression...
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NF-kappaB Binding Activity and Cyclooxygenase-2 Expression in Persistent betaCCI(4)-Treated Rat Liver Injury

Kim SH, Chu HJ, Kang DH, Song GA, Cho M, Yang US, Kim HJ, Chung HY

The involvement of NF-kappaB binding activity is known to be important in the mechanism of acute liver injury and in the induction of cyclooxygenase (COX-2). This study was performed to...
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A Case of Diphyllobothrium nihonkaiense Infection as Confirmed by Mitochondrial COX1 Gene Sequence Analysis

Park SH, Eom KS, Park MS, Kwon OK, Kim HS, Yoon JH

Diphyllobothrium nihonkaiense has been reported in Korea as Diphyllobothrium latum because of their close morphologic resemblance. We have identified a human case of D. nihonkaiense infection using the mitochondrial cytochrome...
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Pilot study of the use of Yin Qiao San in children with conventional antipyretic hypersensitivity

Liew WK, Loh W, Chiang WC, Goh A, Chay OM, Iancovici Kidon M

BACKGROUND: Children with a diagnosis of cross-reactive hypersensitivity to both paracetamol and nonsteroidal anti-inflammatory drugs are limited in their choice of antipyretics. OBJECTIVE: The aim of this pilot study is to...
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Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats

Choi YJ, Kim N, Lee JY, Nam RH, Seo JH, Lee S, Kim HJ, Choi YJ, Lee HS, Lee DH

BACKGROUND/AIMS: This study aimed to examine the gastroprotective effects of PMK-S005, which is a synthetic S-allyl-L-cysteine (SAC; a sulfur-containing amino acid), against acute ethanol-induced gastric damage in rats. METHODS: Sprague-Dawley rats...
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Cordycepin-Enriched WIB801C from Cordyceps militaris Inhibits Collagen-Induced [Ca2+]i Mobilization via cAMP-Dependent Phosphorylation of Inositol 1, 4, 5-Trisphosphate Receptor in Human Platelets

Lee DH, Kim HH, Cho HJ, Yu YB, Kang HC, Kim JL, Lee JJ, Park HJ

  • KMID: 2170640
  • Biomol Ther.
  • 2014 May;22(3):223-231.
In this study, we prepared cordycepin-enriched (CE)-WIB801C, a n-butanol extract of Cordyceps militaris-hypha, and investigated the effect of CE-WIB801C on collagen-induced human platelet aggregation. CE-WIB801C dose-dependently inhibited collagen-induced platelet aggregation,...
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Extracorporeal Worm Extraction of Diphyllobothrium nihonkaiense with Amidotrizoic Acid in a Child

Shin HK, Roh JH, Oh JW, Ryu JS, Goo YK, Chung DI, Kim YJ

Infection cases of diphyllobothriid tapeworms are not much in the below teen-age group. We report a case of Diphyllobothrium nihonkaiense infection in a 13-year-old boy. He presented with severe fatigue,...
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Human bone marrow-derived mesenchymal stem cell gene expression patterns vary with culture conditions

Lee MW, Kim DS, Yoo KH, Kim HR, Jang IK, Lee JH, Kim SY, Son MH, Lee SH, Jung HL, Sung KW, Koo HH

BACKGROUND: Because of the heterogeneity of human mesenchymal stem cells (MSCs), methods for cell expansion in culture and the effects on gene expression are critical factors that need to be...
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The IL-1B Genetic Polymorphism Is Associated with Aspirin-Induced Peptic Ulcers in a Korean Ethnic Group

Cho JH, Choi JS, Chun SW, Lee S, Han KJ, Kim HM

BACKGROUND/AIMS: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In...
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