- Expression of Cyclooxygenase-1 and -2 in Synovial Tissues from Patients with Rheumatoid Arthritis
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Lee YH, Choi SJ, Ji JD, Kim A, Kim CH, Song GG
- KMID: 2142255
- J Korean Rheum Assoc.
- 1998 Nov;5(2):159-168.
No abstract available. -
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- Expression of Cyclooxygenase 1 and 2 in Laryngeal Squamous Cell Carcinoma
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Kim KH, Cho KH, Lee KS, Lim DH, Paik SH, Yang HS, Hong YH, Kim MK
- KMID: 2275793
- Korean J Otolaryngol-Head Neck Surg.
- 2001 Sep;44(9):957-961.
BACKGROUND AND OBJECTIVES: A large body of evidence from a variety of experimental systems suggests that cyclooxygenase-2 (COX-2) is important in carcinogenesis. This study was to determine whether cyclooxygenase-1 (COX-1)... -
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- Expression of cyclooxygenase-1, -2 in human uterine cervix during gestational period
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Oh JH, Kim HS, Yang JI, Kim MS, Yang SC, Han GS, Keum SS, Oh GS
- KMID: 2262123
- Korean J Obstet Gynecol.
- 2000 Nov;43(11):2014-2019.
OBJECTIVE: To determine whether cyclooxygenase (COX)-1 and COX-2 are expressed differentially during the whole gestational period in the pregnant human uterine cervix and if they are involved in the process... -
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- Analgesic and Anti-inflammatory Effects of Ibuprofen, Indomethacin and NS-398 on an Acute Model of Arthritis in Rats
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Kim NJ, Park JY, Han HC, Chang SH
- KMID: 1936258
- Korean J Anesthesiol.
- 2001 Jun;40(6):802-814.
- doi: 10.4097/kjae.2001.40.6.802
BACKGROUND: All currently available nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 and cyclooxygenase-2 and exhibit many complications. It has been suggested that the anti-inflammatory and also most of... -
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- Peripheral Analgesic and Anti-inflammatory Effects of Diclofenac, SC-560 and NS-398 on Acute Arthritic Model in Rats
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Park HS, Park JY, Han HC, Lim HJ, Chang SH, Yoon SM
- KMID: 2236701
- Korean J Anesthesiol.
- 2004 Mar;46(3):336-341.
- doi: 10.4097/kjae.2004.46.3.336
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are generally attributed to suppression cyclooxygenase enzymes, leading to decreased products of the arachidonic acid cascade. Since the discovery of two isoenzymes of cyclooxygenase, inhibition... -
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- Expression of Cyclooxygenase-1, -2 in Human Uterine Cervix of Preterm and Term Pregnancies
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Kim HS, Kim MS, Yang HW, Yang JI, Ahn EJ, Oh KS
- KMID: 2075714
- Korean J Obstet Gynecol.
- 1999 Apr;42(4):784-789.
OBJECTIVE: The purpose of this study was to determine whether cyclooxygenase [COX]-1 and COX-2 are expressed in the pregnant human uterine cervix and if they are expressed differentially between preterm... -
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- Nitric Oxide Donor, NOR-3, Increased Expression of Cyclooxygenase-2, but not of Cyclooxygenase-1 in Cultured VSMC
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Lee DH, Park JE, Kang YJ, Lee KY, Choi HC
- KMID: 2285328
- Korean J Physiol Pharmacol.
- 2006 Jun;10(3):161-165.
NO and cyclooxygenase-2 (COX-2) are contributes to vascular inflammation induced by various stimulation. The mechanism, which explains a linkage between NO and COX-2, could be of importance in promoting pathophysiological... -
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- Melittin-induced Nociceptive Responses are Alleviated by Cyclooxygenase-1 Inhibitor
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Kim J, Shin HK, Lee KH
- KMID: 1512941
- Korean J Physiol Pharmacol.
- 2006 Feb;10(1):45-50.
Melittin-induced pain model has been known to be very useful for the study of pain mechanism. Melittin-induced nociceptive responses are reported to be modulated by the changes in the activity... -
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- Regression of colon polyposis after aspirin medication
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Choi SY, Lee HS, Park SY, Jung MK, Jeon SW, Kim SK
- KMID: 2259163
- Korean J Med.
- 2010 Apr;78(4):485-489.
There is considerable evidence that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of colorectal neoplasia. Unlike cyclooxygenase-1 (COX-1), which is constitutively expressed in the colon, COX-2 is... -
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- Production of Prostaglandin E2 and I2 Is Coupled with Cyclooxygenase-2 in Human Follicular Dendritic Cells
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Cho W, Kim J, Cho KB, Choe J
- KMID: 2150721
- Immune Netw.
- 2011 Dec;11(6):364-367.
- doi: 10.4110/in.2011.11.6.364
BACKGROUND: Prostaglandins (PGs) play pathogenic and protective roles in inflammatory diseases. The novel concept of PGs as immune modulators is being documented by several investigators. By establishing an in vitro... -
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- COX-2 Inhibitors in Inflammatory Bowel Disease: Friends or Foes?
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Park YS
- KMID: 937929
- Korean J Gastroenterol.
- 2007 Dec;50(6):350-355.
The cyclooxygenase (COX) is a key enzyme in the coversion of arachidonic acid to prostaglandins. COX-1 is constitutively expressed and is a critical housekeeping gene, whereas COX-2 is rapidly upregulated... -
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- Update on the Management of Aspirin-Exacerbated Respiratory Disease
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Buchheit K, Laidlaw TM
- KMID: 2165912
- Allergy Asthma Immunol Res.
- 2016 Jul;8(4):298-304.
- doi: 10.4168/aair.2016.8.4.298
Aspirin-exacerbated respiratory disease (AERD) is an adult-onset upper and lower airway disease consisting of eosinophilic nasal polyps, asthma, and respiratory reactions to cyclooxygenase 1 (COX-1) inhibitors. Management includes guideline-based treatment... -
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- Peripheral Analgesic Effects of NSAIDs and Expressions of Cyclooxygenase-1 and Cyclooxygenase-2 in Acute Arthritic Model in Rats
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Lee YS, Park JY, Lim HJ
- KMID: 2032604
- Korean J Anesthesiol.
- 2004 Dec;47(6):862-869.
- doi: 10.4097/kjae.2004.47.6.862
BACKGROUND: Theoretically, an NSAID that inhibits COX-2 selectively should decrease inflammation but not influence normal physiologic functions and thus should cause fewer side effects. In the present study, to investigate... -
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- Aspirin-Exacerbated Respiratory Disease: Evaluation and Management
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Lee RU, Stevenson
- KMID: 2260371
- Allergy Asthma Immunol Res.
- 2011 Jan;3(1):3-10.
- doi: 10.4168/aair.2011.3.1.3
The clinical syndrome of aspirin-exacerbated respiratory disease (AERD) is a condition where inhibition of cyclooxygenase-1 (COX-1) induces attacks of upper and lower airway reactions, including rhinorrhea and varying degrees of... -
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- Effects of Armeniacae Semen and Amygdalin on the Lipopolysaccaride-induced Prostaglandin E2 Synthesis and Nitric Oxide Production in Mouse BV2 Microglial Cells
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Jung HJ, Kim YS, Shin MS, Kim CJ, Kim YS
- KMID: 2165285
- Exp Neurobiol.
- 2008 Dec;17(2):71-78.
- doi: 10.5607/en.2008.17.2.71
Armeniacae semen has been used in traditional medicine for the treatment of pain and inflammatory diseases. Amygdalin is the major compound of Armeniacae semen, and it is used for treatment... -
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- A Case of Gastric Outlet Obstruction Complicated by Peptic Ulcer Secondary to Non-Steroidal Anti-Inflammatory Drug (NSAID)
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Choi CH, Byun SH, Chang SH, Paik SY
- KMID: 2275246
- Korean J Pediatr Gastroenterol Nutr.
- 2005 Sep;8(2):226-232.
Peptic ulcer disease complicated with gastric outlet obstruction is rare in children. Even though NSAIDs have been reported to cause various adverse events, they are still regarded as safe and,... -
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- Inhibitory Effects of Epigallocatechin-3-Gallate on Microsomal Cyclooxygenase-1 Activity in Platelets
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Lee DH, Kim YJ, Kim HH, Cho HJ, Ryu JH, Rhee MH, Park HJ
- KMID: 2170686
- Biomol Ther.
- 2013 Jan;21(1):54-59.
In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea catechins from green tea leaves, on activities of cyclooxygenase (COX)-1 and thromboxane synthase (TXAS),... -
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- Cyclic Expression of Cyclooxygenase-1 and -2 in Human Endometrium
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Park DW, Yang HW, Kwon HC, Hwang KJ, Yoo JY, Lee CH, Kim SK, Cho DJ, Oh KS
- KMID: 2085101
- Korean J Fertil Steril.
- 1998 Apr;25(1):25-33.
Cyclooxygenase (COX) is an enzyme involved in the conversion of arachidonic acid to prostaglandins(PGs), and exists in two forms, COX-1 and COX-2. COX has been reported to be involved in... -
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- 3-Dimensional Culture System of Endometrial Cells for Studying the Human Implantation Mechanism
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Park DW, Yang HW, Kwon HC, Chang KH, Kim SK, Cho DJ, Oh KS
- KMID: 2085112
- Korean J Fertil Steril.
- 1999 Apr;26(1):1-8.
In order to study the implantation mechanism various methods for culture of endometrial cells in vitro have been attempted. However, a disadvantage is that primary cultures of stromal and epithelial... -
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- Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway
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Shin S, Joo SS, Park D, Jeon JH, Kim TK, Kim JS, Park SK, Hwang BY, Kim YB
- KMID: 1106156
- J Vet Sci.
- 2010 Mar;11(1):43-50.
- doi: 10.4142/jvs.2010.11.1.43
The anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG) were investigated in vitro and in vivo using croton oil-induced inflammation models. Croton oil (20 microgram/mL) up-regulated mRNA expression... -
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