- p16(INK4a) Expression in Porokeratosis
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Uryu M, Furue M
- KMID: 2378548
- Ann Dermatol.
- 2017 Jun;29(3):373-376.
- doi: 10.5021/ad.2017.29.3.373
No abstract available. -
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- Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing
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Park BM, Roh JI, Lee J, Lee HW
- KMID: 2459304
- Lab Anim Res.
- 2018 Dec;34(4):264-269.
- doi: 10.5625/lar.2018.34.4.264
Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers.... -
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- Cyclin D1 Overexpression, p16 Loss, and pRb Inactivation Play a Key Role in Pulmonary Carcinogenesis and have a Prognostic Implication for the Long-term Survival in Non-small Cell Lung Carcinoma Patients
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Myong NH
- KMID: 2166001
- Cancer Res Treat.
- 2008 Jun;40(2):45-52.
PURPOSE: We investigated the immunoexpressions of cyclin D1, cyclin-dependent kinase inhibitor p16 and phosphorylated retinoblastoma (p-pRb) proteins in non- small cell lung carcinoma (NSCLC) to demonstrate their key roles in... -
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- DNA Methylation in Lung Cancer
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Lee MK
- KMID: 2200226
- J Lung Cancer.
- 2002 Dec;1(1):23-28.
DNA modification in vertebrate genomes is confined to the self-complementary sequence CpG. Between 60% and 90% of CpGs are methylated at the 5 position of cytosine, and the remainder is... -
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- Aberrant Cell Cycle Regulation in Cervical Carcinoma
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Kim YT, Zhao M
- KMID: 2158138
- Yonsei Med J.
- 2005 Oct;46(5):597-613.
- doi: 10.3349/ymj.2005.46.5.597
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,... -
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- p16(INK4A) promoter hypermethylation and expression of p16(INK4A), cyclin D1, and Rb in papillary thyroid carcinoma
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Kim YJ, Kim HS, Ha YJ, Lee HY, Park KG, Kim MK, Kwon SY
- KMID: 2259183
- Korean J Med.
- 2010 Mar;78(3):333-340.
BACKGROUND/AIMS: Dysregulation of the cell cycle is believed to be important in human neoplasia. p16(INK4A), a regulator of the retinoblastoma protein, is inactivated by several mechanisms, including hypermethylation of the... -
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- Expression of G1 Cell Cycle Regulators in Rat Liver upon Repeated Exposure to Thioacetamide
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Kim KT, Han SY, Jeong JS
- KMID: 760708
- Korean J Hepatol.
- 2007 Mar;13(1):81-90.
BACKGROUND/AIMS: Eukaryotic cell cycle is regulated by signal transduction pathways mediated by complexes of cyclin dependent kinases (CDKs) and their partner cyclins, or by interaction with CDK inhibitors. Thioacetamide... -
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- Immunohistochemical Analysis of Abnormal p16INK4A Protein Expression in Human Breast Cancer
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Song TJ, Moon JS, Lee ES, Lee JB, Choi WJ, Chae GB, Mok YJ, Bae JW, Won NH, Koo BH
- KMID: 2117060
- J Korean Surg Soc.
- 1999 Mar;56(3):326-333.
BACKGROUND: The p16 protein is a cyclin-dependent kinase inhibitor (CDKI) that inhibits cell cycle progression from phase G1 to phase S in the cell cycle. Many p16 gene mutations have... -
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- Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia
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Kim TE, Kim HW, Lee KE
- KMID: 1875754
- Korean J Pathol.
- 2014 Feb;48(1):24-29.
BACKGROUND: This study investigates the prevalence of human papillomavirus (HPV) 52 and 58 genotypes among women residing in Busan, and the expression of p16 and p53 proteins in cervical neoplasia... -
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- The p16INK4A Expression in Stomach Cancer , Colon Cancer and Hepatoma Cell Lines
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Choi SJ, Kim SK, Kim SJ, Koh CM, Park YS
- KMID: 2329146
- J Korean Cancer Assoc.
- 1998 Jun;30(3):527-535.
PURPOSE: The p16(INK4A) gene encodes a specific inhibitor of cell cycle progression. In recent years, genetic deletion and altered expression of p16(INK4A) gene were frequently showed in many human cancers.... -
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- p16INK4A and p15 INK4B Gene Alterations in Primary Uterine Cervical Carcinoma Tissues and Cervical Carcinoma Cell Lines
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Yoo SW, Kim JW
- KMID: 2175348
- J Korean Cancer Assoc.
- 1998 Oct;30(5):1044-1052.
PURPOSE: Alterations of the p15(INK4B) and p16(INK4A) gene which are separated by 25 kb on chromosome 9p21 have been reported in various tumor derived cell lines and primary tumors, but... -
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- Diagnosis of Cervical Neoplasia Using Immunohistochemical Staining of p16(INK4A)
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Kwon JY, Jeong MY, Choi MN, Lee SH, Jang DG, Ryu KS, Rha JG, Han KT
- KMID: 2244596
- Korean J Gynecol Oncol.
- 2005 Mar;16(1):27-33.
OBJECTIVE: There is need for more objective diagnostic parameters to identify cervical dysplastic or neoplastic cells. So, we examined the p16(INK4A) expression in the cervical tissues to evaluate the value... -
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- Expression of p16(INK4A), Rb and E2F-1 Proteins in Colorectal Carcinoma
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Kim SS, Lee TJ, Kim BG, Cha SJ, Park SJ, Lim HM, Park SI
- KMID: 2004529
- J Korean Surg Soc.
- 2003 Aug;65(2):119-125.
PURPOSE: An altered cell cycle regulation may underline the development and progression of human malignancies. The purpose of this study was to determine whether the degree of p16(INK4A), Rb and... -
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- Expression of Cell Cycle Related Genes in HL60 Cells Undergoing Apoptosis by X-irradiation
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Kim JH, Park IK
- KMID: 2323691
- J Korean Soc Ther Radiol Oncol.
- 1998 Dec;16(4):377-388.
PURPOSE: To evaluate changes in expression of cell cycle related genes during apoptosis induced in HL60 cells by X-irradiation to understand molecular biologic aspects in mechanism of radiation therapy. MATERIAL... -
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- Overexpression of p16(INK4A) as a biomarker for ASCUS in ThinPrep(TM) smear
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Yeo SJ, Nam KH, Shim IK, Kim TH, Lee KH, Kim HM, Cho HJ, Kwon KW
- KMID: 1979451
- Korean J Gynecol Oncol.
- 2005 Jun;16(2):141-147.
OBJECTIVE: The overexpression of p16(INK4A) is induced by human papillomavirus (HPV) and associated with the carcinogenesis of cervical epithelia. So, immunostaining of p16(INK4A) may be useful biomarker in detecting CIN... -
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- Blastoid Mantle Cell Lymphoma: A Case Report
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Shin JW, Yang JH, Lee SY, Lee JS, Park YL, Cho MK, Cho HD
- KMID: 2301848
- Korean J Dermatol.
- 2010 Aug;48(8):684-688.
Mantle cell lymphoma (MCL) is a low-grade malignant lymphoma derived from a subset of B-cells localized in the mantle zone of the lymphoid follicle. MCL commonly involves extranodal sites, usually... -
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- Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications
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Chae SW, Sohn JH, Kim DH, Choi YJ, Park YL, Kim K, Cho YH, Pyo JS, Kim JH
- KMID: 1777016
- Yonsei Med J.
- 2011 May;52(3):445-453.
- doi: 10.3349/ymj.2011.52.3.445
PURPOSE: The molecular mechanisms that are responsible for the initiation and progression of breast cancers are largely unknown. This study was to analyze the cyclin B1, cdc2, p53 and p16... -
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- Alterations of p16INK4A and p18INK4C, Human Papillomavirus infections and Expression of the Cell Cycle Associated Proteins in Cervical Carcinomas
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Kwon KI, Kim SP, Suh SI, Hwang MY, Baek WK, Kwon KY, Lee SS, Cho CH, Cha SD
- KMID: 2076224
- Korean J Obstet Gynecol.
- 2001 Apr;44(4):683-691.
OBJECTIVE: We analyzed the gene status of p16INK4A, p18INK4C, the expression of cell cycle associated proteins (p16INK4A, p18INK4C, cyclin D1, CDK4, pRb, and p53), and human papillomavirus (HPV) infection... -
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- Human Papillomavirus Prevalence and Cell Cycle Related Protein Expression in Tonsillar Squamous Cell Carcinomas of Korean Patients with Clinicopathologic Analysis
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Lee M, Kim SB, Lee SW, Roh JL, Choi SH, Nam SY, Kim SY, Cho KJ
- KMID: 2277459
- Korean J Pathol.
- 2013 Apr;47(2):148-157.
BACKGROUND: Human papillomavirus (HPV)-related tonsillar squamous cell carcinoma (TSCC) has recently been characterized as a distinct subset with a favorable prognosis. The prevalence and clinicopathologic significance of HPV-related TSCC in... -
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- Relationship between p16(INK4a), pRb and high risk HPV infection and recurrence
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Nam EJ, Kim HY, Kim SW, Yoon BS, Kim JH, Kim YT, Kim JW, Cho NH, Kim S
- KMID: 2272842
- Korean J Obstet Gynecol.
- 2006 Jul;49(7):1437-1445.
OBJECTIVE: The purpose of this study was to identify the abnormal expressions of p16(INK4a) and pRb in cervical intraepithelial neoplasia (CIN), and then to determine the relationship between the levels... -
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