- BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity
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Kim DH, Do MS
- KMID: 2155394
- Exp Mol Med.
- 2015 Jan;47(1):e129.
- doi: 10.1038/emm.2014.98
Obesity is recognized as a chronic low-grade inflammatory state due to adipose tissue expansion being accompanied by an increase in the production of proinflammatory adipokines. Our group is the first... -
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- Production of Stromal Cell-Derived Factor-1 (SDF-1)and Expression of CXCR4 in Human Bone Marrow Endothelial Cells
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Yun HJ, Jo DY
- KMID: 1130038
- J Korean Med Sci.
- 2003 Oct;18(5):679-685.
- doi: 10.3346/jkms.2003.18.5.679
This study investigated the production of stromal cell-derived factor-1 (SDF-1) and the expression of CXCR4 in human bone marrow endothelial cells (BMECs). Human BMEC cell line BMEC-1 cells expressed SDF-1... -
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- Synthesized TGF-beta s in RPE regulates cellular proliferation
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Lee SC, Seong GJ, Kim SH, Kwon OW
- KMID: 1081831
- Korean J Ophthalmol.
- 1999 Jun;13(1):16-24.
- doi: 10.3341/kjo.1999.13.1.16
Retinal pigment epithelial (RPE) cells transdifferentiate in culture, a transition which is accompanied by a shift in biological activity. The present study investigates whether transforming growth factor (TGF)-beta has the... -
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- Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
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Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS
- KMID: 2154246
- Exp Mol Med.
- 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils... -
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- Circulating factors in sera or peripheral blood mononuclear cells in patients with membranous nephropathy or diabetic nephropathy
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Ihm CG, Park JK, Hong SP, Lee TW, Cho BS, Kim MJ
- KMID: 645115
- J Korean Med Sci.
- 1997 Dec;12(6):539-544.
- doi: 10.3346/jkms.1997.12.6.539
In order to investigate the status of some circulating factors in nephrotic syndrome, we examined the secretion of monocyte chemotactic peptide (MCP)-1, tumor necrosis factor (TNF) alpha or fibronectin... -
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- Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages
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Cho DI, Kim MR, Jeong HY, Jeong HC, Jeong MH, Yoon SH, Kim YS, Ahn Y
- KMID: 2155335
- Exp Mol Med.
- 2014 Jan;46(1):e70.
- doi: 10.1038/emm.2013.135
Mesenchymal stem cells (MSCs) have been widely studied for their applications in stem cell-based regeneration. During myocardial infarction (MI), infiltrated macrophages have pivotal roles in inflammation, angiogenesis and cardiac remodeling.... -
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- Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line
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Park M, Park H, Kim WH, Cho H, Lee JH
- KMID: 1056234
- Exp Mol Med.
- 2005 Jun;37(3):213-219.
Autocrine stimulation via coexpression of hepatocyte growth factor (HGF) and its receptor (Met) has been reported in many human sarcomas, but few in carcinomas. In this report, we found that... -
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- Aldosterone-induced TGF-beta1 Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells
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Han JS, Cho BS, Yang CW, Kim YS
- KMID: 1778162
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S195-S203.
- doi: 10.3346/jkms.2009.24.S1.S195
Aldosterone has been shown to stimulate renal TGF-beta1 expression. However, the mechanisms for aldosterone-induced TGF-beta1 expression have not been clearly determined in mesangial cells. We examined the role of extracellular-signal... -
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- Release of heat shock protein 70 (Hsp70) and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells
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Lee KJ, Kim YM, Kim DY, Jeoung D, Han K, Lee ST, Lee YS, Park KH, Park JH, Kim DJ, Hahn JH
- KMID: 1110120
- Exp Mol Med.
- 2006 Aug;38(4):364-374.
Heat shock protein 70 (Hsp70) release and its effects on pro-inflammatory cytokine production have been controversial. In this study, we investigated whether Hsp70 could be released from monocytes and activates... -
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- Expression of Osteoprotegerin and RANK Ligand in Breast Cancer Bone Metastasis
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Park HR, Min SK, Cho HD, Kim DH, Shin HS, Park YE
- KMID: 648906
- J Korean Med Sci.
- 2003 Aug;18(4):541-546.
- doi: 10.3346/jkms.2003.18.4.541
Bone destruction is primarily mediated by osteoclastic bone resorption, and cancer cells stimulate the formation and activation of osteoclasts next to metastatic foci. Accumulating evidences indicate that receptor activator of... -
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