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Computational Challenges for Integrative Genomics

Kim JH, Magwene P

  • KMID: 1974006
  • Genomics Inform.
  • 2004 Mar;2(1):7-18.
Integrated genomics refers to the use of large-scale, systematically collected data from various sources to address biological and biomedical problems. A critical ingredient to a successful research program in integrated...
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Efficient Mining of Interesting Patterns in Large Biological Sequences

Rashid MM, Karim MR, Jeong BS, Choi HJ

Pattern discovery in biological sequences (e.g., DNA sequences) is one of the most challenging tasks in computational biology and bioinformatics. So far, in most approaches, the number of occurrences is...
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Java DOM Parsers to Convert KGML into SBML and BioPAX Common Exchange Formats

Lee KE, Jang MH, Rhie A, Thong CT, Yang S, Park HS

  • KMID: 2166485
  • Genomics Inform.
  • 2010 Jun;8(2):94-96.
Integrating various pathway data collections to create new biological knowledge is a challenge, for which novel computational tools play a key role. For this purpose, we developed the Java-based conversion...
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VBioindex: A Visual Tool to Estimate Biodiversity

Yu DS, Yoo SH

Biological diversity, also known as biodiversity, is an important criterion for measuring the value of an ecosystem. As biodiversity is closely related to human welfare and quality of life, many...
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Systems Bioinformatics Research Trends

Lee E, Lee D

  • KMID: 2330857
  • J Korean Soc Med Inform.
  • 2008 Dec;14(4):313-327.
Bioinformatics is the information technology to deal with biological data. Recently emerging systems biology has drawn great interest inspired by world-wide efforts for modeling and analyzing biological processes with a...
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Challenges and New Approaches in Genomics and Bioinformatics

Park JH, Han KS

  • KMID: 1973989
  • Genomics Inform.
  • 2003 Sep;1(1):1-6.
No abstract available.
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The Current Trend of Avian Influenza Viruses in Bioinformatics Research

Ahn I, Son HS

OBJECTIVES: Since the first human infection from avian influenza was reported in Hong Kong in 1997, many Asian countries have confirmed outbreaks of highly pathogenic H5N1 avian influenza viruses....
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Introduction of Bioinformatic Methods for the Gene Function Analysis

Kim SS

  • KMID: 760527
  • Korean J Hepatol.
  • 2004 Mar;10(1):11-21.
No abstract available.
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A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties

Park S, Sohn JW, Cho J, Huh Y

The thalamus is a brain structure known to modulate sensory information before relaying to the cortex. The unique ability of a thalamocortical (TC) neuron to switch between the high frequency...
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Imaging Informatics: A New Horizon for Radiology in the Era of Artificial Intelligence, Big Data, and Data Science

Kim JH

We are witnessing the big wave of Industrial Revolution 4.0, enabled by artificial intelligence (AI) and big data, which has shaken the entire industry and day-to-day life as well as...
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Personal Genomics, Bioinformatics, and Variomics

Bhak J, Ghang H, Reja R, Kim S

  • KMID: 2166415
  • Genomics Inform.
  • 2008 Dec;6(4):161-165.
In 2008 at least five complete genome sequences are available. It is known that there are over 15,000,000 genetic variants, called SNPs, in the dbSNP database. The cost of full...
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Bioinformatics Interpretation of Exome Sequencing: Blood Cancer

Kim J, Lee YG, Kim N

We had analyzed 10 exome sequencing data and single nucleotide polymorphism chips for blood cancer provided by the PGM21 (The National Project for Personalized Genomic Medicine) Award program. We had...
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Letter to the Editor: Bioinformatics Analysis in Downstream Genes of the mTOR Pathway to Predict Recurrence and Progression of Bladder Cancer

Li C, Liu H, Xu Y

No abstract available.
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Artificial Intelligence in Medicine

Jeong J

No abstract available.
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Single-Cell Sequencing in Cancer: Recent Applications to Immunogenomics and Multi-omics Tools

Sierant MC, Choi J

Tumor heterogeneity, the cellular mosaic of multiple lineages arising from the process of clonal evolution, has continued to thwart multi-omics analyses using traditional bulk sequencing methods. The application of single-cell...
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An Information-based Model for an Interactive Web Service with Agricultural Biotechnology

Kim CK, Seol YJ, Park DS, Hahn JH

  • KMID: 2053268
  • Genomics Inform.
  • 2011 Jun;9(2):85-88.
The National Agricultural Biotechnology Information Center (NABIC) constructed an agricultural biology-based infrastructure and developed a biological information-based database. The major functions of the NABIC are focused on biotechnological developments for...
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Conceptual Progress for the Improvements in the Selectivity and Efficacy of G Protein-Coupled Receptor Therapeutics: An Overview

Kim KM

No abstract available.
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The Author's Response: Bioinformatics Analysis in Downstream Genes of the mTOR Pathway to Predict Recurrence and Progression of Bladder Cancer

Yoo CH

No abstract available.
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Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing

Cho EH, Min JW, Choi SS, Choi HS, Kim SW

Glucokinase maturity-onset diabetes of the young (GCK-MODY) represents a distinct subgroup of MODY that does not require hyperglycemia-lowering treatment and has very few diabetes-related complications. Three patients from two families...
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An Efficient Approach to Mining Maximal Contiguous Frequent Patterns from Large DNA Sequence Databases

Karim MR, Rashid MM, Jeong BS, Choi HJ

Mining interesting patterns from DNA sequences is one of the most challenging tasks in bioinformatics and computational biology. Maximal contiguous frequent patterns are preferable for expressing the function and structure...
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