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The Expression of Clusterin in Cervical Cancer tissues

Park DC, Shin EY, Lee HY, Kim DH

  • KMID: 2272820
  • Korean J Obstet Gynecol.
  • 2006 Apr;49(4):840-846.
OBJECTIVE: Immunohistochemistry was performed on normal and cervical cancer tissues to determine the differential expression patterns of clusterin. METHODS: Fifteen normal cervical tissues and thirty-two primary cervical cancer tissues were used....
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Clusterin expression and paclitaxel resistance in cervical cancer cell lines

Shin JE, Shin EY, Kim YW, Kim DH, Park DC

  • KMID: 2141698
  • Korean J Obstet Gynecol.
  • 2006 May;49(5):1060-1064.
OBJECTIVE: The purpose of this study was to evaluate whether clusterin expression is significantly correlated with paclitaxel resistance in cervical cancer cell lines. METHODS: The expressions of clusterin in cervical...
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Proapoptotic role of nuclear clusterin in brain

Kim N, Choi WS

Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent...
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Expression of Osteopontin and Clusterin in Transitional Cell Carcinoma of the Bladder: Comparison to the Pathologic Stage

Yoon JH, Lee JH, Yeom BW, Won NH, Yoon DK

  • KMID: 2061107
  • Korean J Urol.
  • 2005 Apr;46(4):341-346.
PURPOSE: This study was performed to evaluate the expressions of osteopontin (OPN) and clusterin in a transitional cell carcinoma (TCC) of the urinary bladder, and then compare their expression rates...
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The Role of Clusterin in Apoptosis Induced by Testicular Torsion

Park EC, Kwak C, Son H, Oh SJ, Lee SE, Choi H

  • KMID: 1914754
  • Korean J Urol.
  • 2004 Apr;45(4):380-389.
PURPOSE: This study examined the histological changes and apoptosis in contralateral rat testes after testicular torsion or the repair of torsion, and investigated the functional role of clusterin in the...
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Clusterin confers paclitaxel resistance in ovarian cancer

Park DC, Yeo SG, Mok SC

  • KMID: 2272700
  • Korean J Obstet Gynecol.
  • 2005 Oct;48(10):2313-2320.
OBJECTIVE: To evaluated whether clusterin over-expression is significantly correlated with paclitaxel resistance in ovarian cancer cell lines. METHODS: Clusterin was validated by performing expression profiling analysis and subsequently, the correlation between...
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The Relationship of Clusterin Expression and Ki-67 Labeling Index with Clinicopathologic Factors in Human Transitional Cell Carcinoma

Chon WH, Lee SD, Lee JZ, Choi KW

  • KMID: 2311945
  • Korean J Urol.
  • 2008 Aug;49(8):688-695.
PURPOSE: This study examined the expression of clusterin and Ki-67 in human transitional cell carcinoma(TCC). In addition, the relationship of clusterin and Ki-67 expression with the clinicopathological factors and prognosis...
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The correlation of clusterin binding affinity to chemotherapeutic agents with chemoresistance in ovarian cancer cells

Choi JH, Suh MJ, Park DC

  • KMID: 2077891
  • Korean J Obstet Gynecol.
  • 2008 Jul;51(7):738-743.
OBJECTIVE: The purpose of this study was to determine the mechanism of action of clusterin?known as a chemo-resistance protein?by analyzing its binding with chemotherapeutic agents and elucidating its relation with...
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Correlation of Clusterin Expression and Apoptosis in Prostate Cancer and Benign Hyperplastic Tissues

Cho JM, Youm YH, Lee HJ, Yang HW, Yoo TK

  • KMID: 2293825
  • Korean J Urol.
  • 2005 Nov;46(11):1147-1154.
PURPOSE: We studied the apoptotic index in prostate cancer tissues and investigated the relationship of apoptosis and clusterin expression. MATERIALS AND METHODS: Forty-two archival prostatectomy specimens of varying grades of prostate...
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The Relationship of Clusterin Expression with Ki-67 Expression and Clinicopathological Factors in Human Renal Cell Carcinoma

Park HC, Kim JM, Lee CL, Lee W, Lee SD, Lee JZ, Chung MK

PURPOSE: This study was performed to evaluate the relationship of the expressions of clusterin with Ki-67 and the clinicopathological factors and significance of clusterin expression in human renal cell carcinoma...
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The Roles of Clusterin on Morphogenesis of Beta Cells During Pancreas Regeneration

Hong SW, Ranjan K, Lee S, Shin YJ, Min BH, Park IS

Clusterin is a highly glycosylated heterodimeric glycoprotein that plays diverse biological roles in various organs. The secreted clusterin has been established as a major form of the protein that exerts...
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The expression of clusterin, bax, p53, Ki-67, and apoptotic index in epithelial ovarian tumors

Lee JY, Na JY, Kim IS, Park MH, Kang JS

OBJECTIVE: The purpose of this study was (1) to evaluate the expressions of clusterin, bax, Ki-67, p53, and apoptotic index in epithelial ovarian tumors, borderline and malignant ovarian tumors, (2)...
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Clusterin Expression and Apoptosis in Transitional Cell Carcinoma of the Bladder

Park HJ, Lee HJ, Yum YH, Kang JY, Yoo TK

PURPOSE: The clusterin expression has been associated with tumorigenesis of various malignancies, including tumors of the prostate, colon and breast. Furthermore, the expression of clusterin is modulated by many factors...
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Inhibition of clusterin gene expression via shRNA increases chemosensitivity to paclitaxel in xenografted PEOH cells

Shin EY, Jeung IC, Choi JH, Park DC

  • KMID: 1926282
  • Korean J Obstet Gynecol.
  • 2007 Nov;50(11):1493-1498.
OBJECTIVE: To evaluate the inhibition of Clusterin gene expression via shRNA decreases proliferation and metastasis and increases chemosensitivity to paclitaxel in xenografted PEOH cells. METHODS: 1 x 10(6) paclitaxel resistant...
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Role of Clusterin and Tumor Necrosis Factor Receptors on the Apoptosis of Prostate Cancer Cells

Joo KJ

PURPOSE: In prostate cancer, the anti-apoptotic mechanism of sulfated glycoprotein-2 (clusterin) against tumor necrosis factor-alpha (TNF-alpha) receptors and the action of type 2 TNF-alpha receptor (TNFR2) were investigated. MATERIALS AND METHODS:...
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Effect of irradiation on expression of clusterin in the rat salivary glands

O GM, Choi YS, Hwang EH, Lee SR

  • KMID: 2270877
  • Korean J Oral Maxillofac Radiol.
  • 2006 Mar;36(1):33-40.
PURPOSE: To investigate clusterin expression in the acini and ductal cells of rat submandibular glands after Co-60 gamma irradiation. MATERIALS AND METHODS: The male Sprague-Dawley rats weighing approximately 250 gm were...
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Expression of Clusterin by Angiotensin II Infusion in the Kidney and the Heart of Rats

Park JH, Cheon H, Choe JH, Yoo KH, Kim SK

  • KMID: 2335441
  • J Korean Pediatr Soc.
  • 1999 Sep;42(9):1261-1271.
PURPOSE: Clusterin is a heterodimeric glycoprotein and its expression is related with tissue injury and apotosis. Angitensisn II(ANG II) is known to be associated with the progression of renal disease...
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Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects

Choi JH, Jeong E, Youn BS, Kim MS

BACKGROUND: Blood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles...
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Effects of Angiotensin Converting Enzyme Inhibition into Apoptosis and Related Genes in the Neonatal Rat Kidney

Yoo KH, Cheon H, Choi BM, Hong YS, Lee JW, Kim SK

  • KMID: 2335419
  • J Korean Pediatr Soc.
  • 1999 Aug;42(8):1086-1095.
PURPOSE: The renin-angiotensin system plays an important role in renal growth and development. Exposuring the neonate to angiotensin converting enzyme(ACE) inhibitor increases mortality and results in growth retardation and abnormal...
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Apoptosis Induction and Clusterin Expression of NRP-152 Cells by Tamsulosin

Youm YH, Yoon YD, Woo JH, Yoo TK

  • KMID: 2330536
  • J Korean Continence Soc.
  • 2006 Dec;10(2):132-139.
PURPOSE: The aim of this study was to know whether and how tamsulosin induces apoptosis of normal rat prostate cells, and the relationship between apoptosis and clusterin expression. MATERIALS AND METHODS:...
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