- Lignans and Macrolides from the Leaves of Houttuynia cordata with Inhibitory Activity against NO Production in Murine Macrophage RAW 264.7 Cells
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Ahn J, Chae HS, Chin YW
- KMID: 2528076
- Nat Prod Sci.
- 2022 Mar;28(1):33-39.
- doi: 10.20307/nps.2022.28.1.33
Eight lignans (1-8) and two macrolides (9-10) were isolated from the CHCl 3 -soluble fraction of Houttuynia cordata Thumb (Saururaceae). Structures of isolates were elucidated by extensive spectroscopic methods. Fatty... -
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- A Case of Favre-Racouchot Syndrome
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Chin YW, Lee JH, Yang JM, Lee YS
- KMID: 1678502
- Korean J Dermatol.
- 1982 Jun;20(3):461-465.
Favre-Racouchot syndrome(nodular elastosis with cysts and comedones) is a peculiar complication of solar elastosis in which comedones, follicular cysts, and nodules of altered elastic tissue occur mainly sround the orbits,... -
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- Chemical Constituents from Agrimonia pilosa with Inhibitory Activity against Interleukin 1β Production via NLRP3 and NLRC4 Inflammasomes
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Nhoek P, Chae HS, An CY, Pel P, Kim YM, Chin YW
- KMID: 2524102
- Nat Prod Sci.
- 2021 Dec;27(4):228-233.
- doi: 10.20307/nps.2021.27.4.228
Bioactivity-guided fractionation by preliminary screening using interleukin-1β production in lipopolysaccharides (LPS)-induced J774A.1 cell line led to the isolation of fourteen structures including chromone, isocoumarins, flavanoids, and triterpenes from the aerial... -
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- A Study on the Anxiety and Depression of Patients with Childhood Atopic Dermatitis
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Kim HS, Chin YW, Park HJ, Kim YC, Lee KK
- KMID: 2303312
- Korean J Dermatol.
- 1998 Aug;36(4):628-634.
BACKGROUND: Atopic dermatitis is a condition which often begins in early infancy as an erythematous, intensely pruritic, maculopapular eruption. The role of anxiety and depression in the course of atopic... -
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- Pharmaceutical Studies on “Dang-Gui†in Korean Journals
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Ahn J, Ahn MJ, Chin YW, Kim J
- KMID: 2468060
- Nat Prod Sci.
- 2019 Dec;25(4):285-292.
- doi: 10.20307/nps.2019.25.4.285
A crude drug “Dang-Guiâ€, belonging to the genus Angelica, has been used as a traditional herbal medicine in Asia. Various studies have investigated the chemical components and pharmacological activities of... -
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- Lignans with NADPH Oxidase 2 (NOX2)-inhibitory Activity from the Fruits of Schisandra chinensis
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Park JM, Pel P, Chin YW, Lee MY
- KMID: 2409611
- Nat Prod Sci.
- 2018 Mar;24(1):59-65.
- doi: 10.20307/nps.2018.24.1.59
An isoform of NADPH oxidase (NOX), NOX2 is a superoxide-generating enzyme involved in diverse pathophysiological events. Although its potential as a therapeutic target has been validated, there is no clinically... -
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- Sinensetin Inhibits Interleukin-6 in Human Mast Cell - 1 Via Signal Transducers and Activators of the Transcription 3 (STAT3) and Nuclear Factor Kappa B (NF-κB) Pathways
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Chae HS, Kim YM, Chin YW
- KMID: 2376491
- Nat Prod Sci.
- 2017 Mar;23(1):1-4.
- doi: 10.20307/nps.2017.23.1.1
Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism... -
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- Anti-Proliferative Activity of Nodosin, a Diterpenoid from Isodon serra, via Regulation of Wnt/β-Catenin Signaling Pathways in Human Colon Cancer Cells
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Bae ES, Kim YM, Kim DH, Byun WS, Park HJ, Chin YW, Lee SK
- KMID: 2505692
- Biomol Ther.
- 2020 Sep;28(5):465-472.
- doi: 10.4062/biomolther.2020.003
Colorectal cancer (CRC) is one of the most malignant type of cancers and its incidence is steadily increasing, due to life style factors that include western diet. Abnormal activation of... -
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- Characterization of KRC-108 as a TrkA Kinase Inhibitor with Anti-Tumor Effects
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Lee HJ, Moon Y, Choi J, Heo JD, Kim S, Nallapaneni HK, Chin YW, Lee J, Han SY
- KMID: 2531001
- Biomol Ther.
- 2022 Jul;30(4):360-367.
- doi: 10.4062/biomolther.2021.195
Tropomyosin receptor kinase A (TrkA) protein is a receptor tyrosine kinase encoded by the NTRK1 gene. TrkA signaling mediates the proliferation, differentiation, and survival of neurons and other cells following... -
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- α, γ-Mangostins Induce Autophagy and Show Synergistic Effect with Gemcitabine in Pancreatic Cancer Cell Lines
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Kim M, Chin YW, Lee EJ
- KMID: 2395810
- Biomol Ther.
- 2017 Nov;25(6):609-617.
- doi: 10.4062/biomolther.2017.074
Pancreatic cancer is one of the most lethal and aggressive cancers in the world. However, no effective treatment is currently available for pancreatic cancer. The objective of this study was... -
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- A Study on the prevalence of Autoantibodies in Korean Pationts with Leprosy
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Moon KC, Chin YW, Kim WS
- KMID: 1677775
- Korean J Dermatol.
- 1978 Dec;16(6):417-421.
It has been increasingly clear that the defence against Mycobacterium leprae(M. leprae) appears mainly to depend on cell-mediated rather than humoral immune mechanism. Nevertheless, the M. leprae is not only... -
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- alpha-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation
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Kim SJ, Hong EH, Lee BR, Park MH, Kim JW, Pyun AR, Kim YJ, Chang SY, Chin YW, Ko HJ
- KMID: 2150757
- Immune Netw.
- 2012 Dec;12(6):253-260.
- doi: 10.4110/in.2012.12.6.253
alpha-Mangostin is a xanthon derivative contained in the fruit hull of mangosteen (Garcinia mangostana L.), and the administration of alpha-Mangostin inhibited the growth of transplanted colon cancer, Her/CT26 cells which... -
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- Isolation And Development Of Quantification Method For Cyanidin-3-glucoside And Cyanidin-3-rutinoside In Mulberry Fruit By High-performance Countercurrent Chromatography And High-performance Liquid Chromatography
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Choi SJ, Jeon H, Lee CU, Yoon SH, Bae SK, Chin YW, Yoon KD
- KMID: 2409594
- Nat Prod Sci.
- 2015 Mar;21(1):20-24.
- doi: 10.0000/nps.2015.21.1.20
Cyanidin-3-glucoside (C3G) and cyanidin-3-rutinoside (C3R) were isolated by high-performance countercurrent chromatography (HPCCC) using a two-phase solvent system composed of tert-butyl methyl ether/n-butanol/acetonitrile/water/trifluoroacetic acid (1 : 3 : 1 : 5... -
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- Activation of transient receptor potential vanilloid 3 by the methanolic extract of Schisandra chinensis fruit and its chemical constituent γ-schisandrin
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Nam Y, Kim HJ, Kim YM, Chin YW, Kim YK, Bae HS, Nam JH, Kim WK
- KMID: 2376959
- Korean J Physiol Pharmacol.
- 2017 May;21(3):309-316.
- doi: 10.4196/kjpp.2017.21.3.309
Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel with modest permeability to calcium ions. It is involved in intracellular calcium signaling and is therefore important in processes... -
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- Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus
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Ahn HN, Jeong SY, Bae GU, Chang M, Zhang D, Liu X, Pei Y, Chin YW, Lee J, Oh SR, Song YS
- KMID: 2170630
- Biomol Ther.
- 2014 Jul;22(4):347-354.
Larrea nitida is a plant that belongs to the Zygophyllaceae family and is widely used in South America to treat inflammatory diseases, tumors and menstrual pain. However, its pharmacological activity... -
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- Efficacy of Itraconazole Melt-Extrusion Tablet One-week Therapy in Treatment of Hyperkeratotic Type of Tinea Pedis and/or Tinea Manus
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Moon KC, Koh JK, Cho BK, Kim HO, Park GS, Byun DG, Kim JW, Jang IK, Yi JY, Jun JB, Yoon TJ, Kim NI, Lee KS, Oh CH, Kim SN, Son SJ, Chin YW, Kim DS, Joe GY, Lee WW, Kwon KS, Suh DH, Moon SE, Park SY, Kim KJ, Lee JS, Lee ES, Choi HJ, Choi EH, Kim KH, Cha SH, Kim YG, Hahm JH, Choi HY, Park SU, Kim BS, Koo SW, Kim BS, Won YH, Kim HU, Song ES, Chung BS, Ro BI, Hong CK, Park JK, Youn TY, Kim HS, Lee CH, Kim KJ, Koo DW, Kim JM, Lee CW, Yu HJ
- KMID: 2303345
- Korean J Dermatol.
- 1999 Aug;37(8):1047-1056.
BACKGROUND: Since the bioavailability of itraconazole capsule is influenced by patients gastric acidity, it results in treatment failure due to its low dissolution and subsequent low absorption when administered in... -
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