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Pathophysiology of Postherpetic Neuralgia

Kim C

Postherpetic neuralgia (PHN) is one of the most extensively investigated neuropathic pains. Much clinical and experimental evidence supports both peripheral and central pathophysiological mechanisms contributing to the pain of PHN....
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The Role of Central Sensitization in Chronic Pain of Rheumatic Diseases

Lee HS

Pain is the most common symptom of almost all rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, osteoarthritis, fibromyalgia, and others. In addition to commonly known peripheral...
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Memory of Pain and Preemptive Analgesia

Song SO

The memory of pain can be more damaging than its initial experience. Several factors are related the directions of pain memory; current pain intensity, emotion, expectation of pain, and peak...
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The effect of ketamine as an additive in epidural block on the intractable herpetic neuralgia: a case report

Lee JY, Sim WS, Kim KM, Oh MS, Lee JE

Ketamine has been shown to have analgesic effect by blocking N-methyl-D-aspartate receptor, thus preventing and reducing central sensitization caused by peripheral nociceptive stimulation. However, due to lack of knowledge about...
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Neuropathic Pain in Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Lee SJ

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has been a frustrating condition that is characterized by pain in areas including the perineum, rectum, prostate, penis, testicles, and abdomen. Unfortunately, effective treatment...
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The effect of pulsed radiofrequency (PRF) for the treatment of supraorbital neuropathic pain: A report of three cases

Bae HM, Kim YH, Kim SW, Moon DE

  • KMID: 2169095
  • Anesth Pain Med.
  • 2012 Apr;7(2):117-120.
Historically, peripheral neuropathic pain has occasionally been difficult to treat. Both a systematic review of the evidence as well as clinical experience have demonstrated that treatment options including polypharmacy provide...
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Expression of Inducible Heat Shock Protein 70 in the Rat's Spinal Cord after the Formalin Test

Hwang JT, Yoon TG, Kim HJ, Yum KW

  • KMID: 1946653
  • J Korean Pain Soc.
  • 2002 Jun;15(1):26-31.
BACKGROUND: Heat shock proteins (HSPs) are induced in the central nervous system by stressful stimuli and are thought to assist in the maintenance of cellular integrity and viability. Recently, several...
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A Case of Mixed Intravenous Infusion of Ketamine and Lidocaine in the Treatment of Post-herpetic Neuralgia

Park JS

  • KMID: 1947107
  • J Korean Pain Soc.
  • 2003 Jun;16(1):97-100.
Post-herpetic neuralgia is a chronic pain syndrome that develops after an acute herpes zoster infection. The zoster-varicella virus causes damage to all parts of the primary sensory neurons, including the...
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The Effect of an Intravenous Ketamine Infusion on a Patient Who Had Suffered from Postherpetic Neuralgia

Lee WY, Lee JH, Hong KH

Postherpetic neuralgia is a kind of neuropathic pain which annoys patients severely for life. Usually people recover from herpes zoster with no pain, but some patients, especially elderly people,...
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The Sphenopalatine Ganglion Radiofrequency Thermocoagulation on a Patient of CRPS with Facial Pain and Pruritus:A report of 2 cases

Park SJ, Moon DE, Kim WY, Park JJ, Cho EJ, Yang SW

Complex regional pain syndrome (CRPS) type 1 is characterized by the presence of pain, which is severe, diffuse and associated with allodynia, and is also associated with autonomic and trophic...
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Clinical Application of alpha2-delta Ligand

Shim JH

Chronic pathological pain is sustained by mechanisms of peripheral and central sensitization, which are being increasingly investigated at the molecular and cellular levels. The molecular mechanisms of sensitization that occur...
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Neuronal Hyperexcitability Mediates Below-Level Central Neuropathic Pain after Spinal Cord Injury in Rats

Park ES, Jeon Y, Cho DC, Youn DH, Gwak YS

  • KMID: 2312071
  • Lab Anim Res.
  • 2010 Sep;26(3):225-232.
Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as...
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Mechanisms of postoperative pain

Kang S, Brennan TJ

Good pain control after surgery is important to facilitate overall recovery, improve patient satisfaction, decrease morbidity, and reduce health care cost. However, despite heightened awareness and development of new guidelines...
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Expression of protein kinase C-gamma mRNA on the spinal cord in a rat model of neuropathic pain

Rhyu IJ, Na HS, Sung B, Kang YH, Kim H, Suh YS

  • KMID: 1530627
  • Korean J Anat.
  • 1999 Dec;32(6):775-778.
Partial peripheral nerve injury occasionally results in neuropathic pain, including spontaneous burning pain and increased sensitivity to sensory stimuli such as hyperalgesia and allodynia. The pathophysiological mechanisms underlying this disease...
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Drug Therapy in Tension-type Headache

Park KW

Tension-type headache is now the term used to describe headaches that have previously been grouped under various ill-defined headings, such as 'tension headache', 'stress headache' and 'muscle contraction headache'. Tension-type...
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Potential Mechanisms Underlying the Increased Excitability of the Bladder Afferent Pathways in Interstitial Cystitis/Bladder Pain Syndrome

Kim DS

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic debilitating disorder associated with lower urinary tract symptoms, including frequency, urgency, and suprapubic pain, which inconveniences the patients and seriously impairs their...
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The Role of Central Group I mGluRs for CFA-induced Knee Joint Pain Model in Rats

Han MA, Chang SH

BACKGROUND: Glutamate is the predominant excitatory neurotransmitter in the central and peripheral nervous system and has known to be involved in nociceptive transmission and central sensitization. It acts through ligand...
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Effect of Intrathecal COX Inhibitors on Inflammatory Pain and c-Fos Expression in Central Nervous System Induced by Formalin Injection in Rat

Seo YS, Lee IO

BACKGROUND: Prostaglandins (PGs) play important roles in the transmission of nociceptive information in the spinal cord. PGs are produced by cyclooxygenase (COX). Two forms of COX have been identified: COX-1...
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Analgesic Effect with Epidural Bupivacaine and Verapamil in Lower Abdominal Surgery

Kim JS, Park JH, Kang SG, Choe HG, Han YJ, Choe H

BACKGROUND: Activation of N-methyl-D-aspartic acid (NMDA) receptors leads to Ca++ entry into the cell and initiates a series of central sensitization such as wind up and longterm potentiation in the...
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Chronic Refractory Cough

Kim SK

Chronic refractory cough is defined as a cough that persists despite guideline based treatment. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a...
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