- Effect of Basic Fibroblast Growth Factor-Saporin (bFGF-SAP) Conjugate on Bovine Choriocapillary Endothelial Cells
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Kim YH, Kim HS, Yoo JS
- KMID: 754377
- Korean J Ophthalmol.
- 2004 Dec;18(2):121-131.
- doi: 10.3341/kjo.2004.18.2.121
We evaluated the effect of a basic fibroblast growth factor (bFGF) and saporin conjugate (bFGF-SAP) on proliferation, migration and tubule formation in bovine choriocapillary endothelial cells (BCECs). Cell proliferation and... -
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- Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration
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Jeon S, Kim NH, Koo BS, Lee HJ, Lee AY
- KMID: 1090963
- Exp Mol Med.
- 2007 Oct;39(5):603-613.
Pigmentation may result from melanocyte proliferation, melanogenesis, migration or increases in dendricity. Recently, it has been reported that secreted phospholipase A2(sPLA2) known as a component of bee venom (BV), stimulates... -
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- Leukotriene B4 pathway regulates the fate of the hematopoietic stem cells
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Chung JW, Kim GY, Mun YC, Ahn JY, Seong CM, Kim JH
- KMID: 1033100
- Exp Mol Med.
- 2005 Feb;37(1):45-50.
Leukotriene B4(LTB4), derived from arachidonic acid, is a potent chemotactic agent and activating factor for hematopoietic cells. In addition to host defense in vivo, several eicosanoids have been reported to... -
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- Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
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Lee J, Hong EM, Jang JA, Park SW, Koh DH, Choi MH, Jang HJ, Kae SH
- KMID: 2363978
- Gut Liver.
- 2016 Mar;10(2):310-317.
- doi: 10.5009/gnl15195
BACKGROUND/AIMS: Statins act as antineoplastic agents through the inhibition of cell proliferation. This study sought to demonstrate the effects of statins on extrahepatic bile duct cancer cell apoptosis and to... -
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- Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells
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Kang DW, Min G, Park DY, Hong KW, Min DS
- KMID: 1104382
- Exp Mol Med.
- 2010 Aug;42(8):555-564.
- doi: 10.3858/emm.2010.42.8.056
Rebamipide a gastroprotective drug, is clinically used for the treatment of gastric ulcers and gastritis, but its actions on gastric cancer are not clearly understood. Phospholipase D (PLD) is overexpressed... -
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- Synergistic Effect of Interleukin-6 and Hyaluronic Acid on Cell Migration and ERK Activation in Human Keratinocytes
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Choi JH, Jun JH, Kim JH, Sung HJ, Lee JH
- KMID: 2151415
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S210-S216.
- doi: 10.3346/jkms.2014.29.S3.S210
Wound healing is initiated and progressed by complex integrated process of cellular, physiologic, and biochemical events, such as inflammation, cell migration and proliferation. Interleukin 6 (IL-6) is a multifunctional cytokine,... -
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- Berberine Inhibited the Growth of Thyroid Cancer Cell Lines 8505C and TPC1
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Park KS, Kim JB, Bae J, Park SY, Jee HG, Lee KE, Youn YK
- KMID: 1120201
- Yonsei Med J.
- 2012 Mar;53(2):346-351.
- doi: 10.3349/ymj.2012.53.2.346
PURPOSE: Thyroid cancer is the most common malignancy in Korean females and can be treated with good prognosis. However, drugs to treat aggressive types of thyroid cancer such as poorly... -
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- Inhibition of corneal neovascularization by rapamycin
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Kwon YS, Kim JC
- KMID: 1111410
- Exp Mol Med.
- 2006 Apr;38(2):173-179.
The purpose of this study was to determine whether rapamycin could inhibit corneal angiogenesis induced by basic fibroblast growth factor (bFGF). Using human dermal microvascular endothelial cells (HDMECs), we examined... -
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- Fluoxetine Protects against Big Endothelin-1 Induced Anti-Apoptosis by Rescuing Kv1.5 Channels in Human Pulmonary Arterial Smooth Muscle Cells
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Dai F, Mao Z, Xia J, Zhu S, Wu Z
- KMID: 1716887
- Yonsei Med J.
- 2012 Jul;53(4):842-848.
- doi: 10.3349/ymj.2012.53.4.842
PURPOSE: Pulmonary Kv channels are thought to play a crucial role in the regulation of cell proliferation and apoptosis. Previous studies have shown that fluoxetine upregulated the expression of Kv1.5... -
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- Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus
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Nam SM, Kim JW, Yoo DY, Choi JH, Kim W, Jung HY, Won MH, Hwang IK, Seong JK, Yoon YS
- KMID: 2344296
- J Vet Sci.
- 2015 Sep;16(3):245-251.
- doi: 10.4142/jvs.2015.16.3.245
Inducible cyclooxygenase-2 (COX-2) has received much attention because of its role in neuro-inflammation and synaptic plasticity. Even though COX-2 levels are high in healthy animals, the function of this factor... -
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- Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells
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Kang DW, Lee JY, Oh DH, Park SY, Woo TM, Kim MK, Park MH, Jang YH, Min DS
- KMID: 756211
- Exp Mol Med.
- 2009 Sep;41(9):678-685.
- doi: 10.3858/emm.2009.41.9.074
In spite of the importance of phospholipase D (PLD) in cell proliferation and tumorigenesis, little is known about the molecules regulating PLD expression. Thus, identification of small molecules inhibiting PLD... -
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- IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1
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Yu SJ, Kim HS, Cho SW, Sohn J
- KMID: 1094082
- Exp Mol Med.
- 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the... -
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- Reduction of adult hippocampal neurogenesis is amplified by aluminum exposure in a model of type 2 diabetes
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Nam SM, Kim JW, Yoo DY, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS
- KMID: 2363330
- J Vet Sci.
- 2016 Mar;17(1):13-20.
- doi: 10.4142/jvs.2016.17.1.13
In this study, we investigated the effects of chronic aluminum (Al) exposure for 10 weeks on cell proliferation and neuroblast differentiation in the hippocampus of type 2 diabetic rats. Six-week-old... -
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- Silencing of ABCG2 by MicroRNA-3163 Inhibits Multidrug Resistance in Retinoblastoma Cancer Stem Cells
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Jia M, Wei Z, Liu P, Zhao X
- KMID: 2373690
- J Korean Med Sci.
- 2016 Jun;31(6):836-842.
- doi: 10.3346/jkms.2016.31.6.836
To investigate the function and regulation mechanism of ATP-binding cassette, subfamily G, member 2 (ABCG2) in retinoblastoma cancer stem cells (RCSCs), a long-term culture of RCSCs from WERI-Rb1 cell line... -
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- Novel EGFR-TK Inhibitor EKB-569 Inhibits Hepatocellular Carcinoma Cell Proliferation by AKT and MAPK Pathways
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Kim H, Lim HY
- KMID: 1786011
- J Korean Med Sci.
- 2011 Dec;26(12):1563-1568.
- doi: 10.3346/jkms.2011.26.12.1563
Epidermal growth factor receptor (EGFR)-targeted therapies have been effective in some cancers, but not in hepatocellular carcinoma (HCC). The aim of this study was to investigate the drug potential to... -
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- Pseudolaric Acid B Inhibits Proliferation, Invasion and Epithelial-to-Mesenchymal Transition in Human Pancreatic Cancer Cell
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Li X, Zhao X, Song W, Tian Z, Yang L, Niu Q, Zhang Q, Xie M, Zhou B, Xu Y, Wu J, Zhang C
- KMID: 2418844
- Yonsei Med J.
- 2018 Jan;59(1):20-27.
- doi: 10.3349/ymj.2018.59.1.20
PURPOSE: This study was aimed to investigate the effect of pseudolaric acid B (PAB) on proliferation, invasion and epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells and to explore the possible... -
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- Immunomodulatory effects of betulinic acid from the bark of white birch on mice
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Yi JE, Obminska-Mrukowicz B, Yuan LY, Yuan H
- KMID: 1072179
- J Vet Sci.
- 2010 Dec;11(4):305-313.
- doi: 10.4142/jvs.2010.11.4.305
The objective of this study was to explore the immunomodulatory effects of betulinic acid (BA) extracted from the bark of white birch on mice. Female mice were orally administered BA... -
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- Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
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Kim DS, Na YJ, Kang MH, Yoon SY, Choi CW
- KMID: 2373811
- Korean J Intern Med.
- 2016 Mar;31(2):357-366.
- doi: 10.3904/kjim.2015.024
BACKGROUND/AIMS: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed,... -
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- The Effect of Chlamydia pneumoniae on the Expression of Peroxisome Proliferator-Activated Receptor-gamma in Vascular Smooth Muscle Cells
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Kim YH, Choi SY, Suh JH, Kim TK, Seung KB, Wang YP, Chang K
- KMID: 1084495
- Yonsei Med J.
- 2008 Apr;49(2):230-236.
- doi: 10.3349/ymj.2008.49.2.230
PURPOSE: This study was designed to investigate the change of peroxisome proliferator-activated receptor gamma (PPARgamma) after the infection of the human coronary artery smooth muscle cells (HCSMCs) with Chlamydia pneumoniae... -
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- The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway
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Park S, Lim S, Chang W, Song H, Lee S, Song BW, Kim HJ, Cha MJ, Choi E, Jang Y, Chung N, Cho SY, Hwang KC
- KMID: 1793194
- Yonsei Med J.
- 2008 Aug;49(4):592-600.
- doi: 10.3349/ymj.2008.49.4.592
PURPOSE: Thiazolidinediones (TZDs) are known to inhibit the proliferation of vascular smooth muscle cell (VSMC) by increasing the activity of p27(Kip1) and retinoblastoma protein (RB). However, the upstream signaling mechanisms... -
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