- Hypoxia in Hepatocellular Carcinoma
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Myung SJ, Yoon JH
- KMID: 760700
- Korean J Hepatol.
- 2007 Mar;13(1):9-19.
Hepatocellular carcinoma (HCC) is characterized by hypervascularity, indicating that angiogenesis plays a vital role in HCC growth and progression. A number of anti-angiogenic therapies are being utilized in clinical trials... -
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- Hypoxia induces Wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells
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Hong KS, Kim HS, Kim SH, Lim DJ, Park JY, Kim SD
- KMID: 1058702
- Exp Mol Med.
- 2011 Dec;43(12):653-659.
- doi: 10.3858/emm.2011.43.12.074
In an oxygen-depleted environment, endothelial cells initiate an adaptive pattern of synthesis, which may enable them to survive hypoxic crises. Using high-resolution two-dimensional gel electrophoresis in conjunction with mass spectroscopy,... -
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- Acute Hypoxia Activates an ENaC-like Channel in Rat Pheochromocytoma (PC12) Cells
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Bae YJ, Yoo JC, Park N, Kang D, Han J, Hwang E, Park JY, Hong SG
- KMID: 1432764
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):57-64.
- doi: 10.4196/kjpp.2013.17.1.57
Cells can resist and even recover from stress induced by acute hypoxia, whereas chronic hypoxia often leads to irreversible damage and eventually death. Although little is known about the response(s)... -
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- Cell-in-Cell Death Is Not Restricted by Caspase-3 Deficiency in MCF-7 Cells
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Wang S, He M, Li L, Liang Z, Zou Z, Tao A
- KMID: 2413947
- J Breast Cancer.
- 2016 Sep;19(3):231-241.
- doi: 10.4048/jbc.2016.19.3.231
PURPOSE: Cell-in-cell structures are created by one living cell entering another homotypic or heterotypic living cell, which usually leads to the death of the internalized cell, specifically through caspase-dependent cell... -
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- The Effect of HIF-1alpha siRNA on Growth and Chemosensitivity of Mia-paca Cell Line
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Yang L, Kang WK
- KMID: 1084504
- Yonsei Med J.
- 2008 Apr;49(2):295-300.
- doi: 10.3349/ymj.2008.49.2.295
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) primarily mediates the hypoxic response. HIF-1alpha induction by various stimuli contributes to cell proliferation and survival. To investigate the effect of HIF-1alpha, we used small interfering... -
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- Changes of 5-hydroxytryptamine release by different glucose concentration from hippocampal slices exposed to hypoxia
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Kang DW, Ahn YS
- KMID: 1123182
- Yonsei Med J.
- 1995 Jun;36(3):271-277.
- doi: 10.3349/ymj.1995.36.3.271
We have previously reported that the spontaneous release of [3H]5-hydroxytryptamine(5-HT) was markedly decreased by hypoxic insult in rat hippocampal slices. In the present study, the effect of glucose on 5-HT... -
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- Expression Pattern of the Thioredoxin System in Human Endothelial Progenitor Cells and Endothelial Cells Under Hypoxic Injury
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Park KJ, Kim YJ, Choi EJ, Park NK, Kim GH, Kim SM, Lee SY, Bae JW, Hwang KK, Kim DW, Cho MC
- KMID: 2225164
- Korean Circ J.
- 2010 Dec;40(12):651-658.
- doi: 10.4070/kcj.2010.40.12.651
BACKGROUND AND OBJECTIVES: The thioredoxin (TRx) system is a ubiquitous thiol oxidoreductase pathway that regulates cellular reduction/oxidation status. Although endothelial cell (EC) hypoxic damage is one of the important pathophysiologic... -
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- Cardioprotection Via Modulation of Calcium Homeostasis by Thiopental in Hypoxia-Reoxygenated Neonatal Rat Cardiomyocytes
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Kim HS, Hwang KC, Park WK
- KMID: 1126016
- Yonsei Med J.
- 2010 Mar;51(2):187-196.
- doi: 10.3349/ymj.2010.51.2.187
PURPOSE: Ca2+ homeostasis plays an important role in myocardial cell injury induced by hypoxia-reoxygenation, and prevention of intracellular Ca2+ overload is key to cardioprotection. Even though thiopental is a frequently... -
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- HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool
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Kim J, So D, Shin HW, Chun YS, Park JW
- KMID: 2344170
- J Korean Med Sci.
- 2015 Oct;30(10):1388-1395.
- doi: 10.3346/jkms.2015.30.10.1388
Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by... -
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- Role of the Nuclear Transcription Factor NF-kappa B Caused by Acute Hypoxia in the Heart
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Joo CU, Juhng WS, Kim JC, Yi HK
- KMID: 2207175
- J Korean Pediatr Soc.
- 2002 Sep;45(9):1106-1113.
PURPOSE: Nuclear factor-kappa B(NF-kappa B) is now recognized as playing a potential role in programmed cell death and the adaptive response to various stress. Cellular hypoxia is a primary manifestation... -
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- Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
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Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ
- KMID: 1503899
- Yonsei Med J.
- 2013 Mar;54(2):374-380.
- doi: 10.3349/ymj.2013.54.2.374
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated... -
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- Association of DNA-dependent protein kinase with hypoxia induciblefactor-1 and its implication inresistance to anticancer drugs in hypoxic tum or cells
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Um JH, Kang CD, Bae JH, Shin GG, Kim DW, Kim DW, Chung BS, Kim SH
- KMID: 1097105
- Exp Mol Med.
- 2004 Jun;36(3):233-242.
Tumor hypoxia contributes to the progression of a malignant phenotype and resistance to ionizing radiation and anticancer drug therapy. Many of these effects in hypoxic tumor cells are mediated by... -
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- Long-term and stable correction of uremic anemia by intramuscular injection of plasmids containing hypoxia-regulated system of erythropoietin expression
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Sun J, Wang Y, Yang J, Du D, Li Z, Wei J, Yang A
- KMID: 1401759
- Exp Mol Med.
- 2012 Nov;44(11):674-683.
Relative deficiency in production of glycoprotein hormone erythropoietin (Epo) is a major cause of renal anemia. This study planned to investigate whether the hypoxia-regulated system of Epo expression, constructed by... -
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- Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells
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Joung YH, Lim EJ, Lee MY, Park JH, Ye SK, Park EU, Kim SY, Zhang Z, Lee KJ, Park DK, Park T, Moon WK, Yang YM
- KMID: 1093470
- Exp Mol Med.
- 2005 Aug;37(4):353-364.
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cellcycle control... -
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- Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis
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Lee SH, Jeong D, Han YS, Baek MJ
- KMID: 2047707
- Ann Surg Treat Res.
- 2015 Jul;89(1):1-8.
- doi: 10.4174/astr.2015.89.1.1
The shaping of new blood vessels is a significant event in cancer growth and metastasis. Therefore, the molecular system of cancer angiogenesis has garnered considerable interest in cancer research. The... -
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- The role of adiponectin in the production of IL-6, IL-8, VEGF and MMPs in human endothelial cells and osteoblasts: implications for arthritic joints
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Lee YA, Ji HI, Lee SH, Hong SJ, Yang HI, Chul Yoo M, Kim KS
- KMID: 2155337
- Exp Mol Med.
- 2014 Jan;46(1):e72.
- doi: 10.1038/emm.2013.141
This study was performed to evaluate the contribution of adiponectin to the production of interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-1 and MMP-13 in human endothelial... -
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- Ischemic postconditioning protects cardiomyocytes against ischemia/reperfusion injury by inducing MIP2
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Zhu HL, Wei X, Qu SL, Zhang C, Zuo XX, Feng YS, Luo Q, Chen GW, Liu MD, Jiang L, Xiao XZ, Wang KK
- KMID: 1022118
- Exp Mol Med.
- 2011 Aug;43(8):437-445.
- doi: 10.3858/emm.2011.43.8.049
Cardiomyocytes can resist ischemia/reperfusion (I/R) injury through ischemic postconditioning (IPoC) which is repetitive ischemia induced during the onset of reperfusion. Myocardial ischemic preconditioning up-regulated protein 2 (MIP2) is a member... -
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- The Effect of Brimonidine on Transepithelial Resistance in a Human Retinal Pigment Epithelial Cell Line
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Park JH, Kim SJ, Yu HG
- KMID: 945988
- Korean J Ophthalmol.
- 2010 Jun;24(3):169-172.
- doi: 10.3341/kjo.2010.24.3.169
PURPOSE: To investigate the effects of brimonidine, an alpha-2-adrenergic agonist, on barrier function in ARPE-19 cells by measuring transepithelial resistance (TER). METHODS: ARPE-19 cells were cultured into a confluent monolayer... -
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- Cathepsin B is activated as an executive protease in fetal rat alveolar type II cells exposed to hyperoxia
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Lee HS, Kim CK
- KMID: 1104392
- Exp Mol Med.
- 2011 Apr;43(4):223-229.
- doi: 10.3858/emm.2011.43.4.027
Alveolar type II cells are main target of hyperoxia-induced lung injury. The authors investigated whether lysosomal protease, cathepsin B (CB), is activated in fetal alveolar type II cells in the... -
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- Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB
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Lee KH, Choi EY, Koh SA, Kim MK, Kim KO, Lee SH, Jang BI, Kim SW, Kim SW, Song SK, Choi JH, Kim JR
- KMID: 1022126
- Exp Mol Med.
- 2011 Sep;43(9):501-509.
- doi: 10.3858/emm.2011.43.9.057
Survivin, a member of the inhibitors of apoptosis protein family, is expressed during development and in various human cancers. However, the clinical relevance of survivin in cancer is still a... -
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