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Regulation of Osteoclast Differentiation: Identification of osteoclast and macrophage fusion protein; DC-STAMP

Miyamoto T

Osteoclasts are bone-resorbing multinuclear cells derived from hematopoietic stem cells or monocyte/ macrophage lineage cells. Recent identification of RANK/RANKL has provided new insights into the osteoclast differentiation pathway, enabling us...
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The Role of Microenvironment in Preserving the Potency of Adult Porcine Pulmonary Valve Stem Cells In Vitro

Chalajour , Siyahian A, Hanley FL

BACKGROUND AND OBJECTIVE: The potency of tissue resident stem cells is regulated primarily by inputs from the local microenvironment. Isolation of stem cells through enzymatic digestion of tissue may affect...
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Study on the Mechanism of the Translocation of Glucose Transporter by Insulin

Hah JS

Insulin stimulates glucose transport in muscle cell and adipocyte via the rapid redistribution of GLUT4 glucose transporters from intracellular membrane compartments to the cell surface. The mechanism that insulin treggers...
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The Effectiveness of IL-12 Administration and Fusion on Tumor Antigen Sensitization Methods for Dendritic Cells Derived from Patients with Myelogenous Leukemia

Kim KW, Park SY, Hong YS

BACKGROUND: Immunotherapy using dendritic cells (DC) loaded with tumor antigens may represent a potentially effective method for inducing antitumor immunity. We evaluated the effectiveness of DC-based antitumor immune response in...
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A Study on Apoptosis of HGPRT- Mouse Myeloma Cell Induced by Aminopterin, a de novo Pathway Blocking Agent

Choi Y, Chung YH

  • KMID: 1550793
  • Korean J Immunol.
  • 1999 Mar;21(1):25-34.
Programmed cell death (PCD), or apoptosis, plays an important role in embryonic development, metamorphsis, hormone-dependent atrophy and tumor growth, as a physiological event regulating the cell number or eliminating damaged...
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Electron Microscopic Analysis of Apoptosis of HGPRT- Mouse Myeloma Cell Induced by Aminopterin, a de novo Pathway Blocking Agent

Choi Y, Chung YH, Cho YJ, Choi YK

  • KMID: 1557242
  • Korean J Immunol.
  • 1998 Dec;20(4):389-396.
Programrned cell death (PCD), or apoptosis, is a process by which cells die in response to specific physiological and toxicological signals. This genetically programmed form of cellular suicide is intirnately...
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Production of the Monoclonal Antibodies against Bartonella henselae Isolated from a Korean Patient

Kil SH, Kang JS

Bartonellosis is spotlighted recently as an emerging zoonosis and Bartonella henselae is reported to be the main infectious agent. In Korea, however, few studies have been made on the epidemiology...
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Propofol promotes osteoclastic bone resorption by increasing DC-STAMP expression

Kim EJ, Kim HJ, Baik SW, Kim KH, Ryu SJ, Kim CH, Shin SW

BACKGROUND: Propofol is an intravenous anesthetic which has antioxidant effects due to its similarity in molecular structure to α-tocopherol. It has been reported that α-tocopherol increases osteoclast fusion and bone...
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Effect of remifentanil on pre-osteoclast cell differentiation in vitro

Jeon HO, Choi IS, Yoon JY, Kim EJ, Yoon JU, Cho AR, Kim HJ, Kim CH

BACKGROUND: The structure and function of bone tissue is maintained through a constant remodeling process, which is maintained by the balance between osteoblasts and osteoclasts. The failure of bone remodeling...
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Brain Tumor Immunology: Part II : Immunotherapy of Malignant Brain Tumors

Hong YK, Rha HK, Jung CK, Lee SW, Jo TH, Baik MW, Yoon SH, Kang JK, Song JU, Choi CR

  • KMID: 2067857
  • J Korean Neurosurg Soc.
  • 1990 Dec;19(10-12):1389-1396.
The prognosis of patients with malignant brain tumors has improved only slightly despite the combined use of surgery, radiation therapy, and chemotherapy. Immunotherapy offers some possibilities and hopes as a...
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Expression of Eta-1 in Escherichia coli and Production of Monoclonal Antibody

Lee SM, Kim MK, Lim BU, Cho H, Kang JS

  • KMID: 2147932
  • Korean J Infect Dis.
  • 1999 Dec;31(6):487-493.
BACKGROUND: Early T-lymphocyte activation-1 (Eta-1) is a secreted phosphoprotein which regulates a variety of cells involved in the immune and nonimmune systems. It is unique in the sense that it...
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Very Small Putative Stem Cells Detected in Human Endometrium

Choi JR, Joo JK, Jun ES, Ko KR, Lee HG, Lee KS, Kim WG

  • KMID: 2036676
  • Korean J Reprod Med.
  • 2010 Jun;37(2):99-113.
OBJECTIVE: It has been recently reported that very small stem cells with pluripotency are detected in murine and human. The purposes of this study are to confirm whether very small...
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The hyperexpressions of putative stem cells in the eutopic endometrium of patients with advanced endometriosis

Choi JR, Joo JK, Na YJ, Ko KR, Lee HG, Lee KS, Lim YT

OBJECTIVE: Recently it has been proposed that stem cells may be associated with the pathogenesis of endometriosis. The purposes of this study are to investigate whether the eutopic endometrial cells...
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Correlations between embryo morphokinetic development and maternal age: Results from an intracytoplasmic sperm injection program

Faramarzi , Khalili MA, Mangoli E

OBJECTIVE: It is widely accepted that aging decreases women’s fertility capacity. The aim of this study was to assess correlations between maternal age and the morphokinetic parameters and cleavage pattern...
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Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir

Hu C, Chen Z, Zhao W, Wei L, Zheng Y, He C, Zeng Y, Yin B

  • KMID: 2170650
  • Biomol Ther.
  • 2014 Mar;22(2):114-121.
Refractoriness of acute myeloid leukemia (AML) cells to chemotherapeutics represents a major clinical barrier. Suicide gene therapy for cancer has been attractive but with limited clinical efficacy. In this study,...
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Effect of IP3 and ryanodine treatments on the development of bovine parthenogenetic and reconstructed embryos

Ahn GJ, Lee BC, Hwang WS

  • KMID: 1103521
  • J Vet Sci.
  • 2001 Aug;2(2):131-137.
For parthenogenetic activation as a model system of nuclear transfer, microinjection and electroporation as activation treatments in bovine metaphase II oocytes were administered to each of three groups as follows:...
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