- Effect of heme oxygenase induction by NO donor on the aortic contractility
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Kim CK, Sohn UD, Lee SY
- KMID: 1606843
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):87-92.
Carbon monoxide (CO) binds to soluble guanylate cyclase to lead its activation and elicits smooth muscle relaxation. The vascular tissues have a high capacity to produce CO, since heme oxygenase-2 (HO-2) is constitutively... -
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- Low Dose Carbon Monoxide Inhalation Prevents Chronic Allograft Nephropathy following Kidney Transplantation in Rats. Heme Oxygenase-1 Derivatives Study I
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Yoon M
- KMID: 2211161
- J Korean Surg Soc.
- 2008 May;74(5):323-329.
PURPOSE: Carbon monoxide (CO), a product of heme catalysis by heme oxygenase (HO-1, HO-2, HO-3), induces cytoprotection against ischemia/reperfusion (I/R) injury in a variety of organs such as the heart,... -
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- The Expression of Thymidylate Synthase in Breast Cancer
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Park JK, Kim JS, Kim KH, Jeon HM, Suh YJ, Park WC, Oh SC, Jung SS, Kim JS, Im SA
- KMID: 2173618
- J Korean Breast Cancer Soc.
- 1999 Dec;2(2):227-239.
- doi: 10.4048/jkbcs.1999.2.2.227
Fluorouracil is well known as a standard chemotherapeutic drug in breast cancer and other cancers that is converted to flurodeoxyuridine monophosphate (FdUMP) and leads to the inhibition of thymidylate synthase... -
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- Purification and refolding of the recombinant subunit B protein of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin
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Jeon YS, Seo SC, Kwon JH, Ko SY, Kim HS
- KMID: 1486869
- J Korean Acad Periodontol.
- 2008 Aug;38(Suppl):343-354.
- doi: 10.5051/jkape.2008.38.Suppl.343
PURPOSE: Aggregatibacter actinomycetemcomitans is associated with localized aggressive periodontitis. It produces cytolethal distending toxin (CDT), which induces cell cycle arrest in the G2/M phase. The CDT holotoxin is composed of... -
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- Purification of Inositol Triphosphate Kinase from Bovine Brain
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Kim HH, Lee JT
- KMID: 2320357
- Yeungnam Univ J Med.
- 1996 Jun;13(1):46-58.
- doi: 10.12701/yujm.1996.13.1.46
Inositol 1,4,5-triphosphate(InsP,) is a second messenger for obilizing intracellular Cal'. It can be dephosphorylated by soluble and particulate forms on InsP, 5-phosphatase, or phosphorylated to produce inositol 1,3,4,5-tetrakisphosphate(InsP,) by InsP,... -
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- Effects of Val34Leu and Val35Leu polymorphism on the enzyme activity of the coagulation factor XIII-A
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Lee IH, Chung SI, Lee SY
- KMID: 755212
- Exp Mol Med.
- 2002 Nov;34(5):385-390.
Change in fibrin stabilizing activity of factor XIII A subunit (FXIII-A) caused by a specific mutation, Val34Leu, is recently implicated to incidences of pathophysiology of thrombosis. In an effort to... -
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- Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
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Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim WJ, Han JA
- KMID: 1389733
- Exp Mol Med.
- 2012 Sep;44(9):536-544.
It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a... -
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- An NH(2)-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells
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Jeon S, Kim KH, Yun CH, Hong BW, Chang YS, Han HS, Yoon YS, Choi WB, Kim S, Lee AY
- KMID: 1052948
- Exp Mol Med.
- 2008 Apr;40(2):254-260.
- doi: 10.3858/emm.2008.40.2.254
Cytochrome P450 3A4 (CYP3A4), is the dominant human liver hemoprotein enzyme localized in the endoplasmic reticulum (ER), and is responsible for the metabolism of more than 50% of clinically relevant... -
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- Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway
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Kim HR, Kim EJ, Yang SH, Jeong ET, Park C, Lee JH, Youn MJ, So HS, Park R
- KMID: 1115939
- Exp Mol Med.
- 2006 Dec;38(6):616-624.
Trichostatin A (TSA), originally developed as an antifungal agent, is one of potent histone deacetylase (HDAC) inhibitors, which are known to cause growth arrest and apoptosis induction of transformed cells,... -
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- Promoter Polymorphism of RRM1 Gene in Korean Lung Cancer Population
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Ko KH, Kim EJ, Oh IJ, Kim SO, Son JG, Jung JP, Cho GJ, Ju JY, Kim KS, Kim YI, Lim SC, Kim YC, Bepler G
- KMID: 1970264
- Tuberc Respir Dis.
- 2006 Sep;61(3):248-255.
- doi: 10.4046/trd.2006.61.3.248
BACKGROUND: LOH11A is a region with frequent allele loss (>75%) in lung cancer that is located on the centromeric part of chromosome 11p15.5. Clinical and cell biological studies suggest that... -
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