- Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Gout
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Son CN, Bang SY, Kim JH, Choi CB, Kim TH, Jun JB
- KMID: 1793042
- J Korean Med Sci.
- 2013 Sep;28(9):1289-1292.
- doi: 10.3346/jkms.2013.28.9.1289
Activation of caspase-1 by NALP3 inflammasomes has been shown to be important in initiating acute gouty arthritis. The objectives of this study were to measure the levels of caspase-1 in... -
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- The Role of Sek1 in Protecting NO-induced Apoptosis in H9c2 cells by Inhibiting Caspase 3 Activation
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Oh J, Park R, So HS, Moon YJ, Baeck Y, Choi MK, Park OK, Lee HI, Chung YT
- KMID: 2092704
- Korean J Anat.
- 1999 Oct;32(5):709-716.
The stress activated protein kinase, or Jun N-terminal kinase (SAPKs/JNKs), is activated in response to a variety of cellular stresses such as changes in osmolarity and metabolism, DNA damage, heat... -
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- Cytotoxicity and Apoptosis of Various Concentrations of Doxorubicin in Methylcholanthrene-induced Rat Fibrosarcoma(MCA) Cells
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Jeong JY, Wang YP, Rha SJ
- KMID: 2062590
- Korean J Thorac Cardiovasc Surg.
- 2001 Jun;34(6):447-453.
BACKGROUND: Although pulmonary resection is the standard approach for the management of pulmonary metastases from soft tissue sarcoma, most of them are unresectable and chemotherapy remains the only option. The... -
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- Pro-Inflammatory Role of S1P₃ in Macrophages
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Heo JY, Im DS
- KMID: 2455092
- Biomol Ther.
- 2019 Jul;27(4):373-380.
- doi: 10.4062/biomolther.2018.215
Sphingosine kinase 1 and its product, sphingosine 1-phosphate (S1P), as well as their receptors, have been implicated in inflammatory responses. The functions of receptors S1Pâ‚ and S1Pâ‚‚ on cell motility... -
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- Induction of Apoptosis by Heavy Metals in HL-60 Cells
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Kim NS, Seong TH, Cho KH, Youm JH, Koh DH
- KMID: 2074981
- Korean J Occup Environ Med.
- 1999 Dec;11(4):557-568.
OBJECTIVES: Apotosis induced by metals and metal-related deleterious conditions has only recently been studied. Although the toxic effects of heavy metal are well described, little is known about the mechanism... -
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- Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner
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Gim E, Shim DW, Hwang I, Shin OS, Yu JW
- KMID: 2466610
- Immune Netw.
- 2019 Dec;19(6):e40.
- doi: 10.4110/in.2019.19.e40
Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neurological disorders including Guillain-Barré syndrome and microcephaly. The host innate immune responses against ZIKV infection are essential for protection; however,... -
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- Effect of TiOâ‚‚ Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness
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Kim BG, Lee PH, Lee SH, Park MK, Jang AS
- KMID: 2371726
- Allergy Asthma Immunol Res.
- 2017 May;9(3):257-264.
- doi: 10.4168/aair.2017.9.3.257
PURPOSE: Nanoparticles (NPs) may cause cell and tissue damage, leading to local and systemic inflammatory responses and adverse effects on health due to the inhalation of particulate matter. The inflammasome... -
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- Inflammatory Bowel Diseases and Inflammasome
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Kim JM
- KMID: 1043328
- Korean J Gastroenterol.
- 2011 Dec;58(6):300-310.
- doi: 10.4166/kjg.2011.58.6.300
Inflammatory bowel disease (IBD), the most important entities being ulcerative colitis and Crohn's disease, are chronic, relapsing and remitting inflammatory conditions that result from chronic dysregulation of the mucosal immune... -
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- Inflammasome as a Therapeutic Target for Cancer Prevention and Treatment
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Thi HT, Hong S
- KMID: 2400769
- J Cancer Prev.
- 2017 Jun;22(2):62-73.
- doi: 10.15430/JCP.2017.22.2.62
Chronic inflammation is a critical modulator of carcinogenesis through secretion of inflammatory cytokines, which leads to the formation of an inflammatory microenvironment. In this process, the inflammasome plays an important... -
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- NLRP3 Inflammasome and Host Protection against Bacterial Infection
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Kim JJ, Jo EK
- KMID: 1777675
- J Korean Med Sci.
- 2013 Oct;28(10):1415-1423.
- doi: 10.3346/jkms.2013.28.10.1415
The inflammasome is a multi-protein complex that induces maturation of inflammatory cytokines interleukin (IL)-1beta and IL-18 through activation of caspase-1. Several nucleotide binding oligomerization domain-like receptor family members, including NLRP3,... -
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- Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-kappaB/Caspase-1 pathway in Sprague-Dawley Rats
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Jia H, Chen W, Yu X, Wu X, Li S, Liu H, Liao J, Liu W, Mi M, Liu L, Cheng D
- KMID: 1705566
- J Vet Sci.
- 2013 Sep;14(3):345-353.
- doi: 10.4142/jvs.2013.14.3.345
The effects of black rice anthocyanidins (BRACs) on retinal damage induced by photochemical stress are not well known. In the present study, Sprague-Dawley rats were fed AIN-93M for 1 week,... -
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- IL-1beta Acts in Synergy with Endogenous IL-1beta in A375-S2 Human Melanoma Cell Apoptosis Through Mitochondrial Pathway
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Wang C, Wang MW, Tashiro SI, Onodera S, Ikejima T
- KMID: 1712732
- J Korean Med Sci.
- 2005 Aug;20(4):555-561.
- doi: 10.3346/jkms.2005.20.4.555
Interleukin-1beta (IL-1beta) is a pivotal proinflammatory cytokine. To investigate the mechanism of IL-1beta-induced cell death in human malignant melanoma A375-S2 cells, MTT assay, photomicroscopical observation, DNA agarose gel electrophoresis, radioimmunoassay... -
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- Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A2 and 12-PGJ2.
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Ahn SG, Kim HS, Jeong SW, Kim BE, Rhim HS, Shim JY, Kim JW, Lee JH, Kim IK
- KMID: 1380233
- Exp Mol Med.
- 2002 Jul;34(3):243-249.
We reported earlier that expression of Sox-4 was found to be elevated during prostaglandin (PG) A2 and delta(12)-PGJ(12) induced apoptosis in human hepatocarcinoma Hep3B cells. In this study, the role... -
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- Withaferin A Inhibits Helicobacter pylori-induced Production of IL-1beta in Dendritic Cells by Regulating NF-kappaB and NLRP3 Inflammasome Activation
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Kim JE, Lee JY, Kang MJ, Jeong YJ, Choi JA, Oh SM, Lee KB, Park JH
- KMID: 2132701
- Immune Netw.
- 2015 Dec;15(6):269-277.
- doi: 10.4110/in.2015.15.6.269
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer, and gastric cancer. There is evidence that IL-1beta is associated with the development of gastric cancer. Therefore, downregulation of H.... -
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- Inflammasomes, multi-cellular protein complex in myeloid cells, induce several metabolic diseases via interleukin-1beta maturation
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Lee GS
- KMID: 1703511
- J Biomed Res.
- 2013 Dec;14(4):195-200.
Inflammation mainly mediated by innate immune cells as the first line of host defense against pathogens is an acute response that limits tissue damage and eliminates pathogens in the body.... -
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- Microarray Analysis of Differentially Expressed Genes in the Brains of Tubby Mice
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Lee JH, Kim CH, Kim DG, Ahn YS
- KMID: 2071657
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):91-97.
- doi: 10.4196/kjpp.2009.13.2.91
The tubby mouse is characterized by progressive retinal and cochlear degeneration and late-onset obesity. These phenotypes are caused by a loss-of-function mutation in the tub gene and are shared with... -
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- The Apoptotic Molecular Changes of Cellular Injury in Mouse Testis Induced by Endocrine Disrupting Chemicals
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Wang EH, Lee KH, Yang KH, Lee J, Jung ES, Kang CS, Choi YJ
- KMID: 2275471
- Korean J Pathol.
- 2004 Aug;38(4):228-237.
BACKGROUND: Spermatogenesis is regulated by various cellular reactions, and especially cell proliferation and apoptosis. METHODS: We investigated the morphological changes and the apoptotic molecular changes in mouse testis induced by... -
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- Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice
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Yoon A, Tammen SA, Park S, Han SN, Choi SW
- KMID: 2412022
- Nutr Res Pract.
- 2017 Apr;11(2):105-113.
- doi: 10.4162/nrp.2017.11.2.105
BACKGROUND/OBJECTIVES: A high-fat diet (HFD) induces obesity, which is a major risk factor for cardiovascular disease and cancer, while a calorie-restricted diet can extend life span by reducing the risk... -
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