- Degradation of the Transcription Factors NF-kappaB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
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Kim KA, Min A, Lee YA, Shin MH
- KMID: 1792210
- Korean J Parasitol.
- 2014 Oct;52(5):459-469.
- doi: 10.3347/kjp.2014.52.5.459
Entamoeba histolytica is a tissue-invasive protozoan parasite causing dysentery in humans. During infection of colonic tissues, amoebic trophozoites are able to kill host cells via apoptosis or necrosis, both of... -
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- CXC and CC Chemokine Expression by Intestinal Epithelial Cells in Response to Clostridium difficile Toxin A
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Jung HC, Kim JM, Kim JS, Song IS, Kim CY
- KMID: 2084982
- Korean J Gastroenterol.
- 2001 May;37(5):345-355.
BACKGROUND/AIMS: Intestinal epithelial cells can play a role in signaling the influx of inflammatory cells. We investigated the regulated expression of CXC and CC chemokines by intestinal epithelial cells in... -
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- Effects of DCA on Cell Cycle Proteins in Colonocytes
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Ha YH, Park DG
- KMID: 2198785
- J Korean Soc Coloproctol.
- 2010 Aug;26(4):254-259.
- doi: 10.3393/jksc.2010.26.4.254
PURPOSE: Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous... -
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- Expression of Inducible Nitric Oxide Synthase and Nitric Oxide Production in Human Gastric Epithelial Cells Infected with Helicobacter pylori
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Kim JM, Kim JS, Jung HC, Song IS, Kim CY
- KMID: 2085014
- Korean J Gastroenterol.
- 2002 May;39(5):324-334.
BACKGROUND/AIMS: Nitric oxide (NO) is known to be an important regulator of inflammatory response. Our aim was to study the role of inducible nitric oxide synthase (iNOS) expression and NO... -
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- Apical acidity decreases inhibitory effect of omeprazole on Mg2+ absorption and claudin-7 and -12 expression in Caco-2 monolayers
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Thongon N, Krishnamra N
- KMID: 1401760
- Exp Mol Med.
- 2012 Nov;44(11):684-693.
Clinical studies reported hypomagnesaemia in long-term omeprazole usage that was probably due to intestinal Mg2+ wasting. Our previous report demonstrated the inhibitory effect of omeprazole on passive Mg2+ transport across... -
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- TNF-alpha Downregulates E-cadherin and Sensitizes Response to gamma-irradiation in Caco-2 Cells
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Yi JY, Jung YJ, Choi SS, Chung E
- KMID: 2128578
- Cancer Res Treat.
- 2009 Sep;41(3):164-170.
PURPOSE: The purpose of the present study was to assess the biological effects of TNF-alpha in Caco-2 well-differentiated colon adenocarcinoma cells and to determine radiation sensitivity in order to develop... -
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- Increased expression of urokinase type plasminogen activator(u-PA), plasminogen activator inhibitor-1(PAI-1), and collagenases in Caco-2 cells infected by Salmonella typhimurium
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Park CG, Goh YJ, Kook SH, Park HK, Kim BJ, Cha CY, Kook YH
- KMID: 645025
- J Korean Med Sci.
- 1997 Feb;12(1):23-31.
- doi: 10.3346/jkms.1997.12.1.23
Salmonella penetrates the basement membrane of intestinal epithelial cells into deeper tissues, in which process extracellular matrix proteases should be required. Hypothesizing that the proteases might be provided by... -
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- Chemopreventive effect of alpha-viniferin in azoxymethane-induced mouse colorectal tumor and Caco-2 cells
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Kwak DH, Shin SK, Youm SY, Kim TW, Kim Y, Ahn B
- KMID: 2286283
- J Biomed Res.
- 2015 Jun;16(2):60-66.
- doi: 10.12729/jbr.2015.16.2.060
alpha-Viniferin (AVF), a trimer of resveratrol, is known to have an anti-inflammatory effect via inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). It has been reported that up-regulated... -
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- Study of the Mechanism for the Growth Inhibitory Effects of Conjugated Linoleic Acid on Caco-2 Colon Cancer Cells
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Oh EJ, Oh YS, Lee HS, Park HS, Yoon JH
- KMID: 2269651
- Korean J Nutr.
- 2003 Apr;36(3):270-279.
Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid (LA) and exhibits anticarcinogenic activity in a variety of animal models. We have previously observed... -
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- Nucleotide Binding Oligomerization Domain 1 Is an Essential Signal Transducer in Human Epithelial Cells Infected with Helicobacter pylori That Induces the Transepithelial Migration of Neutrophils
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Kim BJ, Kim JY, Hwang ES, Kim JG
- KMID: 2155644
- Gut Liver.
- 2015 May;9(3):358-369.
- doi: 10.5009/gnl13218
BACKGROUND/AIMS: The cytosolic host protein nucleotide binding oligomerization domain 1 (Nod1) has emerged as a key pathogen recognition molecule for innate immune responses in epithelial cells. The purpose of the... -
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- Elevated folic acid results in contrasting cancer cell line growth with implications for mandatory folic acid fortification
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Yates Z, Lucock M, Veysey M, Choi JH
- KMID: 2209844
- J Nutr Health.
- 2016 Apr;49(2):72-79.
- doi: 10.4163/jnh.2016.49.2.72
PURPOSE: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to be responsible for several adverse effects,... -
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- Adhesion Activity of Lactobacillus plantarum PM 008 Isolated from Kimchi on the Intestine of Mice
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Jang SE, Hyun YJ, Oh YJ, Choi KB, Kim T, Yeo IH, Han MJ, Kim DH
- KMID: 2168625
- J Bacteriol Virol.
- 2011 Jun;41(2):83-90.
- doi: 10.4167/jbv.2011.41.2.83
Lactic acid bacteria (LAB), including L. plantarum isolated from Kimchi, are beneficial and safe microorganisms that improve disturbances of the indigenous microflora and the host's immune system. The adhesion abilities... -
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- Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model
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Lei X, Cai L, Li X, Xu H, Geng C, Wang C
- KMID: 2410091
- Korean J Physiol Pharmacol.
- 2018 May;22(3):269-275.
- doi: 10.4196/kjpp.2018.22.3.269
Naâº/H⺠exchangers (NHEs) have been shown to be involved in regulating cell volume and maintaining fluid and electrolyte homeostasis. Pooled evidences have suggested that loss of Naâº/H⺠exchanger isoform 8... -
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- In vitro Model System of Transepithelial Migration of Neutrophil by Helicobacter pylori
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Jung HC, Kim JG, Kim JM, Song IS, Park SM
- KMID: 772517
- Korean J Gastroenterol.
- 2003 Jul;42(1):20-26.
BACKGROUND/AIMS: Migration of neutrophil across the intestinal epithelium is a structural hallmark of active intestinal diseases. One of the characteristic histologic features of Helicobacter pylori (H. pylori) infection is... -
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- Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models
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Park MY, Kwon HJ, Sung MK
- KMID: 2313371
- Nutr Res Pract.
- 2009 Mar;3(1):9-14.
Aloe products are one of the top selling health-functional foods in Korea, however the adequate level of intake to achieve desirable effects are not well understood. The objective of this... -
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- Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1
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Shin WG, Park BJ, Lee SJ, Kim JG
- KMID: 2411512
- Korean J Intern Med.
- 2018 Jan;33(1):81-90.
- doi: 10.3904/kjim.2015.409
BACKGROUND/AIMS: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. Infection of human IECs with invasive bacteria... -
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- Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids
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Lee HS, Kim EJ, Oh YS, Cho HJ, Park JH
- KMID: 1804431
- Cancer Res Treat.
- 2001 Oct;33(5):404-413.
PURPOSE: Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of colon cancer is mediated through modulation of eicosanoid... -
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- Postprandial hypoglycemic effects of mulberry twig and root bark in vivo and in vitro
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Park SY, Jin BR, Lee YR, Kim YJ, Park JB, Jeon YH, Choi SW, Kwon O
- KMID: 2158302
- J Nutr Health.
- 2016 Feb;49(1):18-27.
- doi: 10.4163/jnh.2016.49.1.18
PURPOSE: Our previous study demonstrated the hypoglycemic effects of mulberry (Morus alba L.) leaf and the underlying mechanisms. Here we explored the potency of mulberry twigs (TW) and root barks... -
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- Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
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Chelakkot , Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH
- KMID: 2440032
- Exp Mol Med.
- 2018 Feb;50(2):e450.
- doi: 10.1038/emm.2017.282
The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity... -
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- Intestinal anti-inflammatory activity of Sasa quelpaertensis leaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells
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Kim KM, Kim YS, Lim JY, Min SJ, Ko HC, Kim SJ, Kim Y
- KMID: 2313802
- Nutr Res Pract.
- 2015 Feb;9(1):3-10.
- doi: 10.4162/nrp.2015.9.1.3
BACKGROUND/OBJECTIVES: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. Previously, Sasa quelpaertensis leaves have been shown to mediate anti-inflammation and anti-cancer... -
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