- Biotransformation of (-)-alpha-Pinene by Whole Cells of White Rot Fungi, Ceriporia sp. ZLY-2010 and Stereum hirsutum
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Lee SY, Kim SH, Hong CY, Kim HY, Ryu SH, Choi IG
- KMID: 2312826
- Mycobiology.
- 2015 Sep;43(3):297-302.
- doi: 10.5941/MYCO.2015.43.3.297
Two white rot fungi, Ceriporia sp. ZLY-2010 (CER) and Stereum hirsutum (STH) were used as biocatalysts for the biotransformation of (-)-alpha-pinene. After 96 hr, CER converted the bicyclic monoterpene hydrocarbon... -
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- A comparison of biotransformation of volatile anesthetics during moderate length operation
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Kim JH, Chang SH, Kim BY, Jo H, Lim HJ, Chae BK
- KMID: 2236959
- Korean J Anesthesiol.
- 1994 Apr;27(4):347-355.
- doi: 10.4097/kjae.1994.27.4.347
The halogenated anesthetics, halothane, enflurane and isoflurane undergo biotransformation in man. They produce inorganic fluoride ion as a metabolite, which is well known as the cause of methoxyflurane induced nephrotoxicity.... -
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- Influence of Diazepam, Cimetidine and Sulpiride on the Level of Hepatic Microsomal Cytochrome P-450 in Rats
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Kim BH, Ham YA, Hong YS, Sung NE
- KMID: 2170706
- Ewha Med J.
- 1979 Sep;2(3):161-164.
- doi: 10.12771/emj.1979.2.3.161
Cytochrome P-450 is a terminal oxidase of the hepatic microsomal monooxygenase system associated with the oxidative biotransformation of a varity of lipophilic endogenous and exogenous compounds, and generally is assayed... -
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- Increased UDP-Glucuronosyltransferase Activity in the Liver Butylated Hydroxyanisole and Butylated Hydroxytoluence-Treated Rats
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Hong YS
- KMID: 2170841
- Ewha Med J.
- 1990 Dec;13(4):285-291.
- doi: 10.12771/emj.1990.13.4.285
Butylated hydroxyanisole(BHA) has been shown to decrease the toxicological and carcinogenic potential of a variety of chemicals. One possible mechanism for chemoprotection is that BHA increases intestinal UDP-glucronosyltransferase activity and... -
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- CYP3A5*3 Polymorphism and Its Clinical Implications and Pharmacokinetic Role
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Park JY, Cha YJ, Kim KA
- KMID: 2317850
- Transl Clin Pharmacol.
- 2014 Jun;22(1):3-7.
The cytochrome P450 (CYP) 3A subfamily is estimated to participate in the biotransformation of 50% of the currently prescribed drugs. Four members of the CYP3A subfamily have been identified in... -
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- Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites
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Mahmoud YA, Assawah SW, El-Sharkawy SH, Abdel-Salam A
- KMID: 2411408
- Mycobiology.
- 2008 Jun;36(2):121-133.
Aspergillus niger isolated from Allium sativum was used at large scale fermentation (150 mg flavone/200 ml medium) to obtain suitable amounts of the products, efficient for identification. Then spectral analysis... -
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- Multiple exposures of sevoflurane in a patient with hepatic damage from crushing injuries: A case report
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Kim DY, Cho HC, Park SY, Lee JH, Lee JH, Chung CJ
- KMID: 2358480
- Anesth Pain Med.
- 2016 Apr;11(2):172-175.
- doi: 10.17085/apm.2016.11.2.172
Sevoflurane, which has low solubility in blood, facilitates rapid induction and recovery. Sevoflurane is metabolized to hexafluoroisopropanol by cytochrome P450. Hexafluoroisopropanol has significantly less protein binding capability, does not accumulate... -
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- Effect of Enflurane Anesthesia on Patients Treated with Isoniazid
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Lee SY, Lee YJ, Cho CH
- KMID: 2090539
- Korean J Anesthesiol.
- 1990 Apr;23(2):269-276.
- doi: 10.4097/kjae.1990.23.2.269
Enflurane is metabolized in the liver by the hepatic microsomal enzyme system, cytochrome P-450 and induces enzyme during the enflurane exposure. Enhanced biotransformation might occur after enflurane itself and several... -
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- Artificial Liver Devices and Bioartificial Liver Systems: Current Status
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Kwon CH, Lee SK, Park JK, Lee DH, Lee JH
- KMID: 2202344
- J Korean Soc Transplant.
- 2011 Mar;25(1):15-21.
- doi: 10.4285/jkstn.2011.25.1.15
Acute liver failure is a rapidly progressive disease of the liver associated with high morbidity and mortality without liver transplantation. Although good survival after transplantation can be achieved, due to... -
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- Effect of Diabetes in the Human on the Metabolism of Enflurane
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Lee YJ, Lee KJ, Cho CH, Kang MS
- KMID: 1933593
- Korean J Anesthesiol.
- 1991 Apr;24(2):272-277.
- doi: 10.4097/kjae.1991.24.2.272
Enflurane is metabolized in the liver by the hepatic microsomal enzyme system, cytochrome P-450 (P450IIE1) and induces enzyme system during enflurane exposure. Enhanced biotransformation might occur after enflrane itself and... -
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- The Study for Renal Effects of Increased Serum and Urinary Inorganic Fluoride Levels after Prolonged Sevoflurane Anesthesia
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Yoon SH, Yoon JB, Kim TS, Kim HS, Kim KM
- KMID: 2236904
- Korean J Anesthesiol.
- 1996 Dec;31(6):726-732.
- doi: 10.4097/kjae.1996.31.6.726
BACKGROUND: Sevoflurane (CH2F-O-CH(CF3)2) is a fluorinated derivative of ethyl isoprophyl ether. Sevoflurane has a blood/gas partition coefficient of 0.60 that allows a rapid induction and emergence of anesthesia. But sevoflurane... -
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- The Preventive and Curative Effect of Cyanidin-3β-D-Glycoside and Its Metabolite Protocatechuic Acid Against TNBS-induced Colitis in Mice
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Jang SE, Choi JR, Han MJ, Kim DH
- KMID: 2366697
- Nat Prod Sci.
- 2016 Dec;22(4):282-286.
- doi: 10.20307/nps.2016.22.4.282
Cyanidin-3β-D-glycoside (C3G), which is widely distributed in herbal medicines and functional foods, exhibits anti-inflammatory, anti-oxidant, and anti-scratching behavioral effects. Orally administered C3G is metabolized to protocatechuic acid (PA) by gut... -
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- Serum and Urinary Inorganic Fluoride Levels in Major Burn Patients after Sevoflurane Anesthesia
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Kim HS, Kwon YH, Yoon JB, Choi H, Kim KM
- KMID: 1752553
- Korean J Anesthesiol.
- 1994 May;27(5):449-455.
- doi: 10.4097/kjae.1994.27.5.449
Sevoflurane (CH2F-O-CH(CF3)2) is a fluorinated derivative of ethyl isopropyl ether. Sevoflurane has a blood/gas partition coefficient of 0.60 that allows a rapid induction and emergence of anesthesia. There are several... -
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- Effects of Antiepileptic Drugs on Thyroid Hormones and Lipid Profiles
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Park SW, Cho YW, Yi HA, Sohn SI, Lee H, Lim JG, Yi SD
- KMID: 1640568
- J Korean Epilepsy Soc.
- 2004 Dec;8(2):132-137.
PURPOSE: It is known that serum thyroid hormones and lipid profiles are affected by the different biotransformation pathways of antiepileptic drugs (AEDs). The aim of this study was to evaluate... -
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- The Metabolism and Liver Toxicity of N, N-dimethylformamide in the Isolated Perfused Liver
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Koh SB, Cha BS, Kang MG, Koh SY, Lee JW, Kwon SO
- KMID: 2141571
- Korean J Occup Environ Med.
- 1997 Jun;9(2):217-229.
N, N-dimethylformamide (DMF) is a solvent which is widely used in the industrial workplace. It causes the liver damages to the chronically exposed workers and is also well known as... -
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- Cytochrome P450 and Cancer
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Hong YS
- KMID: 2171140
- Ewha Med J.
- 2004 Mar;27(1):41-51.
- doi: 10.12771/emj.2004.27.1.41
The cytochrome P450(P450) are a large group of constitutive and inducible heme-containing enzymes, which have a central role in the oxidative metabolism of a diverse range of xenobiotics. The majority... -
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- The Effects of Halothane, Enflurane, and Regional Anesthesia on SGOT and SGPT
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Choi BS, Cho YH, Lee JC, Yoon YJ, Jin SH
- KMID: 1933760
- Korean J Anesthesiol.
- 1989 Dec;22(6):892-905.
- doi: 10.4097/kjae.1989.22.6.892
When halothane was first introduced into the clinical anesthesia in 1956, it was acclaimed as the ideal anesthetic agent. Soon after its clinical introduction, reports were published regarding jaundice and... -
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- Effect of Thalidomide on the Angiogenesis and In vivo Growth of Hepatoma Cells in the Mouse
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Kim JW, Lee HS, Yoon JH, Kim CY
- KMID: 2304611
- Korean J Gastroenterol.
- 2000 Aug;36(2):235-244.
BACKGROUND/AIMS: Thalidomide shows an antiangiogenic effect after metabolic activation in the rabbit, but the antiangiogenic effect in the mouse has not been established. This study was aimed to know if... -
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- Genetic Safety Study of Chlorpromazine
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Kim HG, Shon YH, Lee KH, Yoon TH, Nam KS
- KMID: 2340464
- J Korean Neuropsychiatr Assoc.
- 2000 May;39(3):629-637.
OBJECT: The aim of this study is to determine whether exposure to chlorpromazine causes mutagenicity and genetic disorders. METHOD: Ames (Salmonella typhimurium) test and Rec assay (Bacillus subtilis) were used as... -
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- Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai
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Hong CE, Lyu SY
- KMID: 2317846
- Toxicol Res.
- 2013 Dec;29(4):279-283.
Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment... -
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