- Polymorphism of a COLIA1 Gene Sp1 Binding Site in Korean Women with Pelvic Organ Prolapse
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Cho HJ, Jung HJ, Kim SK, Choi JR, Cho NH, Bai SW
- KMID: 1758618
- Yonsei Med J.
- 2009 Aug;50(4):564-568.
- doi: 10.3349/ymj.2009.50.4.564
PURPOSE: To evaluate the possible influence of G-->T substitution at the Sp1-binding site of the COLIA1 gene on the risk of pelvic organ prolapse (POP). MATERIALS AND METHODS: The study... -
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- The role of tonicity responsive enhancer sites in the transcriptional regulation of human hsp70-2 in response to hypertonic stress
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Heo JI, Lee MS, Kim JH, Lee JS, Kim J, Park JB, Lee JY, Han JA, Kim JI
- KMID: 1094155
- Exp Mol Med.
- 2006 Jun;38(3):295-301.
The inducible 70 kDa heat shock proteins (Hsp70) in mice are encoded by two almost identical genes, hsp70.1 and hsp70.3. Studies have found that only hsp70.1 is induced by hypertonic... -
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- Weakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction
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Kang JH, Chang SY, Yeom DH, Kim SA, Um SH, Hong KJ
- KMID: 1094074
- Exp Mol Med.
- 2004 Aug;36(4):300-310.
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp-1 promoter (nucleotides... -
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- Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development
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Lee SY, Lee HS, Moon JS, Kim JI, Park JB, Lee JY, Park MJ, Kim J
- KMID: 1123768
- Exp Mol Med.
- 2004 Oct;36(5):468-475.
The heterodimeric c-Jun/c-Fos, an activator protein-1 (AP-1) has been implicated in mesoderm induction (Dong et al., 1996; Kim et al., 1998) whereas the homodimer of c-Jun was reported to be... -
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- Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression
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Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY, Chun KH
- KMID: 1383801
- Exp Mol Med.
- 2012 Jun;44(6):387-393.
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, the underlying molecular mechanisms remain largely unknown. In this study, we investigated the effect and possible mechanism... -
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- Mutation analysis of PAH gene and characterization of a recurrent deletion mutation in Korean patients with phenylketonuria
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Lee YW, Lee DH, Kim ND, Lee ST, Ahn JY, Choi TY, Lee YK, Kim SH, Kim JW, Ki CS
- KMID: 1104807
- Exp Mol Med.
- 2008 Oct;40(5):533-540.
- doi: 10.3858/emm.2008.40.5.533
Phenylketonuria (PKU; MIM 261600) is an autosomal recessive metabolic disorder caused by a deficiency of phenylalanine hydroxylase (PAH; EC 1.14.16.1). Point mutations in the PAH gene are known to cause... -
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