- Expression of BRCA1 Transcripts and Protein in Sporadic Ovarian Cancer
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Park CS, Kim JK
- KMID: 2261114
- Korean J Obstet Gynecol.
- 1998 Aug;41(8):2131-2145.
Recently the breast cancer susceptibility (BRCA1) gene on chromosome 17q has been isolated and identified as a tumor supressor gene that is mutated in many cases of inherited breast and... -
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- The BRCA1 Expression in Placenta of Normal and Fetal Growth Restriction
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Moon JS, Jeong JH, Park CS, Yang SH, Roh JR, Song SY
- KMID: 2261402
- Korean J Obstet Gynecol.
- 1999 Jun;42(6):1260-1266.
OBJECTIVE: BRCA1, the breast and ovarian cancer susceptibility gene, is regarded as not only a tumor suppressor gene but regulator of cell growth and differentiation. We hypothesized that there is... -
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- Novel Germline Mutations of BRCA1 and BRCA2 in Korean Familial Breast Cancer Patients
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Kim HN, Shin MH, Lee R, Park MH, Kweon SS
- KMID: 2447211
- Chonnam Med J.
- 2019 May;55(2):99-103.
- doi: 10.4068/cmj.2019.55.2.99
Breast cancer is the second most common cancer in Korean women. Germline mutations in the BRCA1 and BRCA2 genes cause hereditary breast cancer and are detected in 15–20% of hereditary... -
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- Flow Cytometric Analysis of BRCA1 Protein in Sporadic Breast Cancer
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Lee SM, Sons KS, Lee HD
- KMID: 2006863
- J Korean Cancer Assoc.
- 1998 Aug;30(4):701-710.
PURPOSE: To study the subcellular localization with flow-cytometry and to evaluate their prognostic values. MATERIALS AND METHODS: The breast tissues were obtained from 28 patients with breast cancer and 6... -
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- Clinical significance of variants of unknown significances in BRCA genes
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Choi MC
- KMID: 2450245
- J Gynecol Oncol.
- 2019 Jul;30(4):e80.
- doi: 10.3802/jgo.2019.30.e80
No abstract available. -
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- Comparison of Targeted Next-Generation and Sanger Sequencing for the BRCA1 and BRCA2 Mutation Screening
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Park J, Jang W, Chae H, Kim Y, Chi HY, Kim M
- KMID: 2373527
- Ann Lab Med.
- 2016 Mar;36(2):197-201.
- doi: 10.3343/alm.2016.36.2.197
No abstract available. -
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- Germline Mutations of BRCA1 Gene in Korean Breast and/or Ovarian Cancer Families
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Won YJ, Oh JH, Huang XH, Noh DY, Choe KJ, Kang SB, Kim LS, Noh MS, Paik NS, Yang DH, Oh SM, Lee SN, Park JG
- KMID: 2059138
- J Korean Cancer Assoc.
- 1997 Oct;29(5):713-723.
PURPOSE: To understand the involvement of BRCA1 gene in Korean breast and/or ovarian cancer families. MATERIALS AND METHODS: Germline mutations of BRCA1 gene were analyzed in 13 families which included... -
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- A Novel Germline Mutation in BRCA1 Causes Exon 20 Skipping in a Korean Family with a History of Breast Cancer
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Yoon KA, Kong SY, Lee EJ, Cho JN, Chang S, Lee ES
- KMID: 2438999
- J Breast Cancer.
- 2017 Sep;20(3):310-313.
- doi: 10.4048/jbc.2017.20.3.310
Germline mutations in the BRCA1 and BRCA2 genes are strong genetic factors for predispositions to breast, ovarian, and other related cancers. This report describes a family with a history of... -
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- The Expression of ERCC1, RRM1, and BRCA1 in Breast Cancer According to the Immunohistochemical Phenotypes
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Kim D, Jung W, Koo JS
- KMID: 2157871
- J Korean Med Sci.
- 2011 Mar;26(3):352-359.
- doi: 10.3346/jkms.2011.26.3.352
We studied the expression of BRCA1, ERCC1, and RRM1 which play an important role in DNA repair systems in breast cancer. Immunohistochemical staining for EGFR, BRCA1, ERCC1, and RRM1 were... -
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- BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers
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Semmler L, Reiter-Brennan C, Klein A
- KMID: 2441847
- J Breast Cancer.
- 2019 Mar;22(1):1-14.
- doi: 10.4048/jbc.2019.22.e6
Since the first cloning of BRCA1 in 1994, many of its cellular interactions have been elucidated. However, its highly specific role in tumorigenesis in the breast tissue—carriers of BRCA1 mutations... -
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- Trophoblast Apoptosis and BRCA1 Expression in Fetal Growth Restriction Pregnancy
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Moon CS, Chung JY
- KMID: 2013146
- Korean J Obstet Gynecol.
- 2006 Mar;49(3):527-535.
OBJECTIVE: To know the role of trophoblast apoptosis and BRCA1 on pregnancy of intra-uterine fetal growth restriction (FGR). BRCA1 is regarded as not only a tumor suppressor gene but regulator... -
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- Clinically Significant Unclassified Variants in BRCA1 and BRCA2 genes among Korean Breast Cancer Patients
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Yoon KA, Park B, Lee BI, Yang MJ, Kong SY, Lee ES
- KMID: 2388308
- Cancer Res Treat.
- 2017 Jul;49(3):627-634.
- doi: 10.4143/crt.2016.292
PURPOSE: Unclassified variants (UVs) of BRCA1 and BRCA2 genes are not defined as pathogenic for breast cancer, and their clinical significance currently remains undefined. Therefore, this study was conducted to... -
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- Deletion of the Importin-alpha Gene in the Breast Cancer Cell
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Song BJ, Kim CS, Jin MO, Kim DH, Moon YH, Kim IS, Oh ST, Chung SS, Lee JH, Song YT
- KMID: 2095638
- J Korean Surg Soc.
- 1999 Jun;56(Suppl):947-956.
BACKGROUND: BRCA1 (breast-cancer gene 1) is a tumor suppressor gene that accounts for nearly all families of both early onset breast and ovarian cancer and about 45% of families with... -
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- Conditional knockout of brca1/2 and p53 in mouse ovarian surface epithelium: Do they play a role in ovarian carcinogenesis?
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Kim KY, Park DW, Jeung EB, Choi KC
- KMID: 1072177
- J Vet Sci.
- 2010 Dec;11(4):291-297.
- doi: 10.4142/jvs.2010.11.4.291
Alterations of genes are known to be critical for the induction of tumorigenesis, but the mechanism of ovarian carcinogenesis is little understood and remains to be elucidated. In this study,... -
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- Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines
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Avila-Arroyo S, Nunez GS, Garcia-Fernandez LF, Galmarini
- KMID: 2176281
- J Breast Cancer.
- 2015 Dec;18(4):329-338.
- doi: 10.4048/jbc.2015.18.4.329
PURPOSE: Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition of nucleotide-excision repair and poly (ADP-ribose) polymerase (PARP)... -
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- Prevalence of BRCA1 and BRCA2 Mutations in Korean Breast Cancer Patients
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Ahn SH, Hwang UK, Kwak BS, Yoon HS, Ku BK, Kang HJ, Kim JS, Ko BK, Ko CD, Yoon KS, Cho DY, Kim JS, Son BH
- KMID: 1733488
- J Korean Med Sci.
- 2004 Apr;19(2):269-274.
- doi: 10.3346/jkms.2004.19.2.269
The incidence of breast cancer in Korea has been increasing in recent years, such that it is now the most common female cancer. Breast cancer in Korea is characterized by... -
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