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Dopaminergic Neurons in the Diencephalon of Striped Field Mouse[Apodemus agrarius coreae]

Jung YG, Lee NS, Min SH, Kim MG

  • KMID: 2224602
  • Korean J Anat.
  • 1997 Dec;30(6):609-622.
The distributions and morphological characteristics of neurons displaying immunoreactivity to the catecholamine synthetic enzymes, tyrosine hydroxylase[TH], dopamine-beta-hydroxylase[DBH], and phenyletha-nolamine-N-methyltransferase[PNMT] were examined in the adjacent sections of the diencephalon of the...
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Changes of TH Immunoreactivities and Melatonin Treatments in the Rat Brain by Chronic Stress

Kim MS

  • KMID: 1564367
  • Korean J Anat.
  • 2005 Aug;38(4):315-324.
These experiments were performed to investigate the effect of saline, melatonin, stress, stressedmelatonin on TH immunoreactivity in rat brain. The animals were injected with melatonin (1 mg/kg, i.p.) after electric...
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Postnatal Development of Brain Natriuretic Peptide-immunoreactive Neuron in the Hypothalamus of the Rat

Chung YY, Jeong YW, Park YL, Kim JJ, Moon JS, Fu J, Oh JW

  • KMID: 1517129
  • Korean J Phys Anthropol.
  • 2004 Mar;17(1):1-10.
Brain natriuretic peptide (BNP) is a neuropeptide, isolated from porcine brain that is homologous with atriopeptin. Magnocellular neurosecretory cells located in the paraventricular nucleus and supraoptic nucleus synthesize and secrete...
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5-hydroxy-L-tryptophan Suppressed Food Intake in Rats Despite an Increase in the Arcuate NPY Expression

Moon YW, Choi SH, Yoo SB, Lee JH, Jahng JW

This study was conducted to define the underlying mechanism of hypophagia induced by increased central serotonergic action. Rats received 3 daily injections of 5-hydroxy-L-tryptophan (5-HTP), a serotonin precursor, at a...
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Expression and Distribution of BDNF (Brain Derived Neurotrophic Factor) in the Rat Hypothalamus

Lee YI, Hyun JK

  • KMID: 2092960
  • Korean J Anat.
  • 2009 Jun;42(2):131-138.
BDNF belongs to the neurotrophin family and important molecular mediator of functional and structural plasticity. The highest levels of BDNF are found in the hippocampus and hypothalamus of the adult...
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Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System

Liu X, Herbison A

Kisspeptin signaling at the gonadotropin-releasing hormone (GnRH) neuron is now relatively well characterized and established as being critical for the neural control of fertility. However, kisspeptin fibers and the kisspeptin...
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Acute Effects of Capsaicin on Proopioimelanocortin mRNA Levels in the Arcuate Nucleus of Sprague-Dawley Rats

Lee JS, Kim SG, Kim HK, Baek SY, Kim CM

  • KMID: 2316181
  • Psychiatry Investig.
  • 2012 Jun;9(2):187-190.
OBJECTIVE: Capsaicin, a noxious stimulant and main component of the hot flavor of red peppers, has an analgesic effect when administered to humans. We investigated the expression of proopioimelanocortin (POMC)...
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Location of CNS Labeled Neurons Innervating the Rat Thymus Using the Pseudorabies Virus

Byun DS, Sin SY, Seo JE, Lee CH, Lee BH, Lee MS

  • KMID: 2071848
  • Korean J Phys Anthropol.
  • 1999 Jun;12(1):123-137.
This experimental studies was to investigate the location of CNS labeled neurons following injection of pseudorabies virus (PRV), Bartha strain, into the rat thymus. After survival times of 96~120 hours...
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Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats

Park ES, Yi SJ, Kim JS, Lee HS, Lee IS, Seong JK, Jin HK, Yoon YS

  • KMID: 1093623
  • J Vet Sci.
  • 2004 Dec;5(4):295-302.
This study was aimed to investigate the changes of orexin-A (OXA) and neuropeptide Y (NPY) expression in the hypothalamus of the fasted and high-fat diet fed rats. For the experiments,...
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Fos Expression Induced by Combined Injection of Leptin and Cholecystokinin in the Rat Brain

Kim YU, You KS, Kang HS, Chung CH, Hwang TS

  • KMID: 2199982
  • J Korean Soc Endocrinol.
  • 2002 Aug;17(4):486-500.
BACKGROUND: Several studies have reported that cholecystokinin (CCK), a short-term meal related satiety signal, and leptin, long-term signal for controlling feeding behaviour and body weight, act synergistically to inhibit food...
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Expression of Proopiomelanocortin (POMC) Gene in Rat Hypothalamus and Pituitary Gland as Studied by In Situ Hybridization

Kim SR, Cho SH, Kim KT, Cho SH, Hwang YY, Moon H

  • KMID: 2261614
  • Korean J Obstet Gynecol.
  • 1999 Dec;42(12):2800-2805.
OBJECTIVE: Proopiomelanocortin (POMC) gene is involved in various neuroendocrine reproductive activities and its principal areas of expression are hypothalamus and pituitary gland. However, as it is known as low copy...
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Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake

Yoon YR, Baik JH

BACKGROUND: The melanocortin 4 receptor (MC4R) is involved in the regulation of homeostatic energy balance by the hypothalamus. Recent reports showed that MC4R can also control the motivation for food...
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The Role of Adipose Tissue Vasculature in Energy Balance

Kim HJ, Choi SH, Chun BG, Kim DH

The prevalence of obesity is rapidly growing throughout the developing and developed world. Given the seriousness of obesity, it critically needs to develop new therapeutic ways to defend against its...
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The Effects of Metformin Given into the Brain on Food Intake and a Expressions of Hypothalamic Neurotransmitters in the Rats

Kim ES, Kim JY, Kim SW, Park JY, Lee KU, Hong SK

  • KMID: 2331691
  • J Korean Diabetes Assoc.
  • 1998 Dec;22(4):475-481.
BACKGROUND: Metformin, a biguanide agent, is an oral hypoglycemic agent frequently prescribed to non-insulin-dependent diabetic patients. In adclition to the glucose lowering effect, it is known to suppress fol intake,...
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The Effect of Ghrelin on Ca2+ Concentration in Thyroid FRTL-5 Cells

Kim BJ, Park YJ, Park DJ, So I, Kim KW

  • KMID: 1611346
  • Korean J Physiol Pharmacol.
  • 2004 Aug;8(4):195-200.
Ghrelin is a newly discovered peptide, which is released from the stomach and neurons in the hypothalamic arcuate nucleus (ARC), and potently stimulates growth hormone release and food intake. In...
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Effects of Intracerebroventricular Infusion of MTII in Monosodium Glutamate(MSG)-obese Rats

Kwon OJ, Choi DW, Huh JY, Bae JJ, Kim JH, Park YK, Kim JY, Kim YW

  • KMID: 2323282
  • J Korean Soc Study Obes.
  • 2004 Jun;13(2):101-109.
BACKGROUND: Leptin, secreted by adipose tissue, is an afferent signal molecule that contributes to body fat homeostasis through regulation of both food intake and energy expenditure. These effects are mediated...
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Herpes Virus Entry Mediator Signaling in the Brain Is Imperative in Acute Inflammation-Induced Anorexia and Body Weight Loss

Kim KK, Jin SH, Lee BJ

BACKGROUND: Reduced appetite and body weight loss are typical symptoms of inflammatory diseases. A number of inflammatory stimuli are responsible for the imbalance in energy homeostasis, leading to metabolic disorders....
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Mechanisms of action and clinical applications of anti-obesity drugs currently available in Korea

Kim KK

Over the last 5 years, the Korean Ministry of Food and Drug Safety has approved four anti-obesity drugs for long-term weight management. In this review, the mechanisms of action and...
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Effect of ICV Corticosterone on hypothalamic NPY mRNA Expression in food-restricted, Adrenalectomized Rats

Kim YJ, Kim MR, Nam MS, Kim YS

  • KMID: 2142201
  • J Korean Soc Endocrinol.
  • 1998 Jun;13(2):150-155.
BACKGROUND: Adrenalectomy does impair the expression of hypothalamic NPY gene in the rat and replacement of glucocorticoid by intracerebroventricular(ICV) route resulted in a normalization of refeeding hyperphagia and weight gain...
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Naloxone Increases the Anorexic Effect of MTII in OLETF Rats

Bae JH, Park YH, Kim SH, Park SY, Kim JY, Son JY, Huh JY, Won KC, Kim YW

BACKGROUND: Leptin, an adipocyte-derived hormone, inhibits obesity in lean subjects, but is not widely used because of leptin resistance. Thus, circumventing the arcuate nucleus of the hypothalamus, the site responsible...
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