- Apoptosis
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Kim IK
- KMID: 644894
- J Korean Med Sci.
- 1995 Oct;10(5):307-313.
- doi: 10.3346/jkms.1995.10.5.307
No abstract available. -
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- Human Brain Astrocytes Mediate TRAIL-mediated Apoptosis after Treatment with IFN-gamma
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Lee J, Shin JS, Choi IH
- KMID: 1715853
- Yonsei Med J.
- 2006 Jun;47(3):354-358.
- doi: 10.3349/ymj.2006.47.3.354
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1beta TNF-alphaor IFN-gamma TRAIL was induced in... -
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- Therapeutic Modulation of Apoptosis: Targeting the BCL-2 Family at the Interface of the Mitochondrial Membrane
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Nemec KN, Khaled AR
- KMID: 2158185
- Yonsei Med J.
- 2008 Oct;49(5):689-697.
- doi: 10.3349/ymj.2008.49.5.689
A vast portion of human disease results when the process of apoptosis is defective. Disorders resulting from inappropriate cell death range from autoimmune and neurodegenerative conditions to heart disease. Conversely,... -
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- Sphingosine 1-Phosphate Triggers Apoptotic Signal for B16 Melanoma Cells via ERK and Caspase Activation
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Shin JH, Choi GS, Kang WH, Myung KB
- KMID: 1713191
- J Korean Med Sci.
- 2007 Apr;22(2):298-304.
- doi: 10.3346/jkms.2007.22.2.298
The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), recently was reported to induce apoptosis of some cancer cells and neurons, although it generally known to exert mitogenic and antiapoptotic effects. In... -
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- Gap junction blockage promotes cadmium-induced apoptosis in BRL 3A derived from Buffalo rat liver cells
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Hu D, Zou H, Han T, Xie J, Dai N, Zhuo L, Gu J, Bian J, Yuan Y, Liu X, Liu Z
- KMID: 2363336
- J Vet Sci.
- 2016 Mar;17(1):63-70.
- doi: 10.4142/jvs.2016.17.1.63
Gap junctions mediate direct communication between cells; however, toxicological cascade triggered by nonessential metals can abrogate cellular signaling mediated by gap junctions. Although cadmium (Cd) is known to induce apoptosis... -
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- Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2
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Yun DH, Jeon ES, Sung SM, Ryu SH, Kim JH
- KMID: 1110121
- Exp Mol Med.
- 2006 Aug;38(4):375-384.
Lysophosphatidylcholine (LPC) is a bioactive lipid generated by phospholipase A2-mediated hydrolysis of phosphatidylcholine. In the present study, we demonstrate that LPC stimulates phospholipase D2 (PLD2) activity in rat pheochromocytoma PC12... -
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- Apoptosis, bcl2 expression, and cell cycle analyses in nickel(II)-treated normal rat kidney cells
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Lee SH, Choi JG, Cho MH
- KMID: 648251
- J Korean Med Sci.
- 2001 Apr;16(2):165-168.
- doi: 10.3346/jkms.2001.16.2.165
Nickel compounds are carcinogenic to human and are potent inducers of kidney and lung tumors in experimental animals. In this study, the effects of nickel(II) acetate on apoptosis, cell cycle... -
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- Caffeine Induces Apoptosis in Human Neuroblastoma Cell Line SK-N-MC
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Jang MH, Shin MC, Kang IS, Baik HH, Cho YH, Chu JP, Kim EH, Kim CJ
- KMID: 1127262
- J Korean Med Sci.
- 2002 Oct;17(5):674-678.
- doi: 10.3346/jkms.2002.17.5.674
Caffeine is one of the most widely consumed neuroactive drugs, coming mostly from everyday beverages such as coffee and tea. To investigate whether caffeine induces apoptosis in the central... -
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- Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells
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Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR
- KMID: 1110128
- Exp Mol Med.
- 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis... -
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- Metabolic loading of guanosine induces chondrocyte apoptosis via the Fas pathway
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Kim DJ, Chung JH, Ryu EK, Rhim JH, Ryu YS, Park SH, Kim KT, Kang HS, Chung HK, Park SC
- KMID: 1110124
- Exp Mol Med.
- 2006 Aug;38(4):401-407.
Although the apoptosis of chondrocytes plays an important role in endochondral ossification, its mechanism has not been elucidated. In this study, we show that guanosine induces chondrocyte apoptosis based on... -
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- Alterations in antioxidant function and cell apoptosis in duck spleen exposed to molybdenum and/or cadmium
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Zhang M, Luo J, Zhang C, Cao H, Xia B, Hu G
- KMID: 2412572
- J Vet Sci.
- 2017 Jun;18(2):193-200.
- doi: 10.4142/jvs.2017.18.2.193
To investigate the effects of molybdenum (Mo) and/or cadmium (Cd) on antioxidant function and the apoptosis-related genes in duck spleens. Sixty healthy 11-day-old ducks were randomly divided into six groups... -
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- Prostaglandin A2 Induces Caspase-independent Apoptosis in Hepatocellular Carcinoma Cells
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Kim HS, Shim JC, Choi JY, Rhim H, Kim IK
- KMID: 760582
- Korean J Hepatol.
- 2005 Mar;11(1):72-79.
BACKGROUND/AIMS: Prostaglandin (PG) A2 has been reported to inhibit the growth of hepatocellular carcinoma cells via activation of apoptosis, although the molecular mechanisms involved have not been clarified, yet.... -
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- Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells
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Kim YS, Jhon DY, Lee KY
- KMID: 1380210
- Exp Mol Med.
- 2004 Apr;36(2):157-164.
Selenium is a dietary essential trace nutrient with important biological roles. Selenocompounds were reported to induce apoptosis in many types of tumor cells. In this study, we investigated the signaling... -
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- alpha-Tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells
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Lim SJ, Choi MK, Kim MJ, Kim JK
- KMID: 1009395
- Exp Mol Med.
- 2009 Oct;41(10):737-745.
- doi: 10.3858/emm.2009.41.10.080
Paclitaxel is one of the chemotheraputic drugs widely used for the treatment of nonsmall cell lung cancer (NSCLC) patients. Here, we tested the ability of alpha-tocopheryl succinate (TOS), another promising... -
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- Involvement of the Fas and Fas ligand in testicular germ cell apoptosis by zearalenone in rat
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Jee Y, Noh EM, Cho ES, Son HY
- KMID: 1110857
- J Vet Sci.
- 2010 Jun;11(2):115-119.
- doi: 10.4142/jvs.2010.11.2.115
Zearalenone (ZEA), a nonsteroidal estrogenic mycotoxin, is known to cause testicular toxicity in animals. In the present study, the effects of ZEA on spermatogenesis and possible mechanisms involved in germ... -
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- Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
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Lee J, Hong EM, Jang JA, Park SW, Koh DH, Choi MH, Jang HJ, Kae SH
- KMID: 2363978
- Gut Liver.
- 2016 Mar;10(2):310-317.
- doi: 10.5009/gnl15195
BACKGROUND/AIMS: Statins act as antineoplastic agents through the inhibition of cell proliferation. This study sought to demonstrate the effects of statins on extrahepatic bile duct cancer cell apoptosis and to... -
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- Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model
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Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WH
- KMID: 1397449
- Exp Mol Med.
- 2012 Jul;44(7):448-456.
Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate... -
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- Effects of Peroxisome Proliferator-activated Receptor-gamma Agonist on Fas-mediated Apoptosis in HT-29 Cells
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Chung YW, Han DS, Kang EK, Lee JS, Lee HR, Kim JB, Park JY, Kim YS, Lee OY, Choi HS, Sohn JH, Yoo DH, Hahm JS
- KMID: 772519
- Korean J Gastroenterol.
- 2003 Jul;42(1):35-41.
BACKGROUND/AIMS: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a critical role in adipocytes differentiation and insulin sensitivity and is also related to regulation of inflammation and cell proliferation. The aim of... -
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- Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
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Zhao H, Liu W, Wang Y, Dai N, Gu J, Yuan Y, Liu X, Bian J, Liu ZP
- KMID: 2344302
- J Vet Sci.
- 2015 Sep;16(3):297-306.
- doi: 10.4142/jvs.2015.16.3.297
Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell... -
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- Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
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Park MH, Lee DH
- KMID: 1103592
- Exp Mol Med.
- 2008 Feb;40(1):92-97.
- doi: 10.3858/emm.2008.40.1.92
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and... -
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