- Letter to the Editor: Antiproliferation and Redifferentiation in Thyroid Cancer Cell Line by Polyphenol Phytochemicals
-
Kim TY
- KMID: 1786003
- J Korean Med Sci.
- 2011 Oct;26(10):1397-1397.
- doi: 10.3346/jkms.2011.26.10.1397
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
-
Kim DS, Na YJ, Kang MH, Yoon SY, Choi CW
- KMID: 2373811
- Korean J Intern Med.
- 2016 Mar;31(2):357-366.
- doi: 10.3904/kjim.2015.024
BACKGROUND/AIMS: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed,... -
- CITED
-
- Close
- SHARE
-
- Close
- Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression
-
Kim JH, Park JJ, Lee BJ, Joo MK, Chun HJ, Lee SW, Bak YT
- KMID: 2411963
- Gut Liver.
- 2016 May;10(3):369-374.
- doi: 10.5009/gnl15208
BACKGROUND/AIMS: Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma... -
- CITED
-
- Close
- SHARE
-
- Close
- The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity
-
Zhou GF, Liu QT, Zhou B, Qiu YF, Liu XD, Ma ZY, Feng XL, Cao RB, Chen PY
- KMID: 2344305
- J Vet Sci.
- 2015 Sep;16(3):325-331.
- doi: 10.4142/jvs.2015.16.3.325
The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects... -
- CITED
-
- Close
- SHARE
-
- Close
- Novel EGFR-TK Inhibitor EKB-569 Inhibits Hepatocellular Carcinoma Cell Proliferation by AKT and MAPK Pathways
-
Kim H, Lim HY
- KMID: 1786011
- J Korean Med Sci.
- 2011 Dec;26(12):1563-1568.
- doi: 10.3346/jkms.2011.26.12.1563
Epidermal growth factor receptor (EGFR)-targeted therapies have been effective in some cancers, but not in hepatocellular carcinoma (HCC). The aim of this study was to investigate the drug potential to... -
- CITED
-
- Close
- SHARE
-
- Close
- Combined treatment with silibinin and either sorafenib or gefitinib enhances their growth-inhibiting effects in hepatocellular carcinoma cells
-
Gu HR, Park SC, Choi SJ, Lee JC, Kim YC, Han CJ, Kim J, Yang KY, Kim YJ, Noh GY, No SH, Jeong JH
- KMID: 2155291
- Clin Mol Hepatol.
- 2015 Mar;21(1):49-59.
- doi: 10.3350/cmh.2015.21.1.49
BACKGROUND/AIMS: Silibinin, the main component of silymarin, is used as a hepatoprotectant and exhibits anticancer effects against various cancer cells. This study evaluated the effects of a combination of silibinin... -
- CITED
-
- Close
- SHARE
-
- Close
- Cancer cell metabolism: implications for therapeutic targets
-
Jang M, Kim SS, Lee J
- KMID: 2154264
- Exp Mol Med.
- 2013 Oct;45(10):e45.
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of anticancer drugs and desferrioxamine in combination with radiation on hepatoma cell lines
-
Kim WH, Chon CY, Moon YM, Kang JK, Park IS, Choi HJ
- KMID: 1107404
- Yonsei Med J.
- 1993 Mar;34(1):45-56.
- doi: 10.3349/ymj.1993.34.1.45
Several anticancer chemotherapeutic agents (5-fluorouracil, adriamycin and cisplatinum) and desferrioxamine, an iron chelator, were tested with regard to cytotoxicity and to the combined effect on radiation induced cell killing using... -
- CITED
-
- Close
- SHARE
-
- Close
- Antiproliferation and Redifferentiation in Thyroid Cancer Cell Lines by Polyphenol Phytochemicals
-
Kang HJ, Youn YK, Hong MK, Kim LS
- KMID: 1094260
- J Korean Med Sci.
- 2011 Jul;26(7):893-899.
- doi: 10.3346/jkms.2011.26.7.893
Thyroid carcinogenesis is accompanied by loss of thyroid-specific functions and refractory to radioiodine and thyroid stimulating hormone (TSH) suppression therapy. Redifferentiating agents have been shown to inhibit tumor growth and... -
- CITED
-
- Close
- SHARE
-
- Close
- The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
-
Kim WG, Choi HJ, Kim TY, Shong YK, Kim WB
- KMID: 2070111
- Korean J Intern Med.
- 2014 Jul;29(4):474-481.
BACKGROUND/AIMS: 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of... -
- CITED
-
- Close
- SHARE
-
- Close
- Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy
-
Yu T, Tang B, Sun X
- KMID: 2419104
- Yonsei Med J.
- 2017 May;58(3):489-496.
- doi: 10.3349/ymj.2017.58.3.489
Hypoxia is frequently observed in solid tumors and also one of the major obstacles for effective cancer therapies. Cancer cells take advantage of their ability to adapt hypoxia to initiate... -
- CITED
-
- Close
- SHARE
-
- Close
- Modulation of the Surface Expression of CD158 Killer Cell Ig-like Receptor by Interleukin-2 and Transforming Growth Factor-beta
-
Shin EC, Choi KS, Kim SJ, Shin JS
- KMID: 1734134
- Yonsei Med J.
- 2004 Jun;45(3):510-514.
- doi: 10.3349/ymj.2004.45.3.510
Killer cell Ig-like receptor (KIR) binds to HLA class I molecules on the surface of target cells, and it confers inhibitory signals to NK cells. Although NK cytotoxicity can be... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of curcumin on the interaction between androgen receptor and Wnt/beta-catenin in LNCaP xenografts
-
Hong JH, Lee G, Choi HY
- KMID: 2344105
- Korean J Urol.
- 2015 Sep;56(9):656-665.
- doi: 10.4111/kju.2015.56.9.656
PURPOSE: Curcumin is a nontoxic, chemopreventive agent possessing multifaceted functions. Our previous study showed that curcumin inhibits androgen receptor (AR) through modulation of Wnt/beta-catenin signaling in LNCaP cells. Therefore, we... -
- CITED
-
- Close
- SHARE
-
- Close
- Human Brain Astrocytes Mediate TRAIL-mediated Apoptosis after Treatment with IFN-gamma
-
Lee J, Shin JS, Choi IH
- KMID: 1715853
- Yonsei Med J.
- 2006 Jun;47(3):354-358.
- doi: 10.3349/ymj.2006.47.3.354
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1beta TNF-alphaor IFN-gamma TRAIL was induced in... -
- CITED
-
- Close
- SHARE
-
- Close
- Transactivation of bad by vorinostat-induced acetylated p53 enhances doxorubicin-induced cytotoxicity in cervical cancer cells
-
Lee SJ, Hwang SO, Noh EJ, Kim DU, Nam M, Kim JH, Nam JH, Hoe KL
- KMID: 2155341
- Exp Mol Med.
- 2014 Feb;46(2):e76.
- doi: 10.1038/emm.2013.149
Vorinostat (VOR) has been reported to enhance the cytotoxic effects of doxorubicin (DOX) with fewer side effects because of the lower DOX dosage in breast cancer cells. In this study,... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells
-
Hong YB, Kang HJ, Kim HJ, Rosen EM, Dakshanamurthy S, Rondanin R, Baruchello R, Grisolia G, Daniele S, Bae I
- KMID: 1123462
- Exp Mol Med.
- 2009 Mar;41(3):151-160.
- doi: 10.3858/emm.2009.41.3.018
Resveratrol has been reported to possess cancer preventive properties. In this study, we analyzed anti-tumor activity of a newly synthesized resveratrol analog, cis-3,4',5-trimethoxy-3'-hydroxystilbene (hereafter called 11b) towards breast and pancreatic... -
- CITED
-
- Close
- SHARE
-
- Close
- Antitumor activity of five new platinum complexes having a glycolate leaving ligand
-
Hong WS, Min YI, Kim HT, Cho YB, Kim KH, Kim DK
- KMID: 644887
- J Korean Med Sci.
- 1995 Aug;10(4):269-274.
- doi: 10.3346/jkms.1995.10.4.269
In an attempt to develop a new anticancer platinum complex with greater or equivalent antitumor activity but reduced side effects compared with cisplatin (CDDP), a series of new platinum complexes... -
- CITED
-
- Close
- SHARE
-
- Close
- Human Telomerase Reverse Transcriptase (hTERT): A Target Molecule for the Treatment of Cisplatin-resistant Tumors
-
Park YP, Kim KD, Kang SH, Yoon DY, Park JW, Kim JW, Lee HG
- KMID: 1781577
- Korean J Lab Med.
- 2008 Dec;28(6):430-437.
- doi: 10.3343/kjlm.2008.28.6.430
BACKGROUND: Human telomerase reverse transcriptase (hTERT) is a catalytic enzyme that is required for telomerase activity (TA) and cancer progression. Telomerase inhibition or inactivation increases cellular sensitivity to UV irradiation,... -
- CITED
-
- Close
- SHARE
-
- Close
- Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line
-
Lee YY, Kim HP, Kang MJ, Cho BK, Han SW, Kim TY, Yi EC
- KMID: 2154283
- Exp Mol Med.
- 2013 Nov;45(11):e64.
Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases, has shown promising results as a growth inhibitor of HER2-positive... -
- CITED
-
- Close
- SHARE
-
- Close
- Potential Antitumor Activity of SIM-89 in Non-Small Cell Lung Cancer Cells
-
Pei J, Chu T, Shao M, Teng J, Sha H, Gu A, Li R, Qian J, Mao W, Li Y, Han B
- KMID: 2419116
- Yonsei Med J.
- 2017 May;58(3):581-591.
- doi: 10.3349/ymj.2017.58.3.581
PURPOSE: c-Met and its ligand, hepatocyte growth factor (HGF), play a critical role in oncogenesis and metastatic progression. The aim of this study was to identify inhibited enzymogram and to... -
- CITED
-
- Close
- SHARE
-
- Close
