- Sensitivity of CD95-induced apoptosis in different proliferative status of human retinal pigment epithelial cells
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Chang JH, Kang SW, Ham DI
- KMID: 754300
- Korean J Ophthalmol.
- 2001 Dec;15(2):74-80.
- doi: 10.3341/kjo.2001.15.2.74
It is known that CD95 (APO-1/Fas) is expressed on the cell surface, and apoptotic cell death can be induced by the CD95 ligation in the cultured, proliferating human retinal pigment... -
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- CD43 cross-linking increases the Fas-induced apoptosis through induction of Fas aggregation in Jurkat T-cells
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Kim HJ, Park HJ, Park WS, Bae Y
- KMID: 1110119
- Exp Mol Med.
- 2006 Aug;38(4):357-363.
CD43 (sialophorin, leukosialin) is a heavily sialylated surface protein expressed on most leukocytes and platelets including T cells. Although CD43 antigen is known to have multiple and complex structure, exact... -
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- The effect of cyclophosphamide on Fas-mediated apoptosis
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Lee JH, Park JH, Yang MH
- KMID: 1038387
- J Korean Med Sci.
- 1997 Jun;12(3):185-189.
- doi: 10.3346/jkms.1997.12.3.185
Fas is a cell surface protein that can mediate apoptosis and belongs to the tumor necrosis factor (TNF) receptor family. Anti-Fas antibody induces apoptotic cell death in... -
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- A Case of Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin
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Lee SY, Choi YS, You CE, Park MY, Son SJ
- KMID: 1639602
- Korean J Dermatol.
- 2006 Mar;44(3):350-352.
Toxic epidermal necrolysis (TEN) is a rare, life-threatening, mucocutaneous drug reaction, which causes extensive epidermal detachment and serious complications involving ocular structures and internal organs. Recently, intravenous immunoglobulin (IVIG) was... -
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- Distinct Patterns of Cleavage and Translocation of Cell Cycle Control Proteins in CD95-induced and p53-induced apoptosis
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Park WS, Jung KC, Chung DH, Nam WD, Choi WJ, Bae Y
- KMID: 648894
- J Korean Med Sci.
- 2003 Aug;18(4):467-472.
- doi: 10.3346/jkms.2003.18.4.467
Apoptotic cell death induced by p53 occurs at a late G1 cell cycle checkpoint termed the restriction(R)point, and it has been proposed that p53-induced apoptosis causes upregulation of CD95. However,... -
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- Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin
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Lee J, Kang JS, Choi BY, Keum YS
- KMID: 2374614
- Biomol Ther.
- 2016 Nov;24(6):604-609.
- doi: 10.4062/biomolther.2016.028
5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, finding... -
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- A Case of Toxic Epidermal Necrolysis Treated with High Dose Intravenous Immunoglobulin
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Han MH, Kang SK, Sung KJ, Moon KC, Koh JK, Choi JH
- KMID: 2303251
- Korean J Dermatol.
- 2000 Jul;38(7):940-944.
Toxic epidermal necrolysis(TEN) is the most dramatic, life-threatening cutaneous drug reaction. TEN is characterized by extensive detachment of the epidermis undergoing full-thickness necrosis. The pathogenetic pathway and specific treatments of... -
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- The Induction of Apoptosis by Fas Antibody, IFN - delta, IL - 1 alpha in Normal Human Keratinocytes and KB cells
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Lee HK, Whang KU, Park YL, Kim YK, Norris DA
- KMID: 2230637
- Korean J Dermatol.
- 1997 Apr;35(2):273-278.
BACKGROUND: The Fas antigen is a cell surface molecule that mediates apoptosis in many cell types. Matsues group indicated that keratinocytes constitutively express the Fas antigen and apoptosis was induced... -
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- The Fas Antigen Expression in Liver Tissues of Patients with Chronic Hepatitis B
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Hong SP, Kim KC, Cha YS, Choi YJ, Guk JW, Choi YJ, Kim BY, Park PW, Im GS
- KMID: 2240645
- Korean J Gastroenterol.
- 1998 Feb;31(2):204-211.
Backgroud/Aims: Liver damage in chronic B viral hepatitis depends on host immune response, not direct toxicity. Fas-Fas ligand interaction induced apoptosis plays an important role in liver damage from viral... -
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- S-Fas Urinary Excretion Helps to Predict the Immunosuppressive Treatment Outcomes in Patients with Proliferative Primary Glomerulonephritis
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Zwiech R
- KMID: 1777684
- J Korean Med Sci.
- 2013 Oct;28(10):1474-1481.
- doi: 10.3346/jkms.2013.28.10.1474
Deregulation of soluble apoptosis stimulating fragment (sFas) plays an important role in glomerulonephritis (GN). The study assed the influence of immunosuppressive treatment on serum and urine sFas in patients with... -
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- Expression of dendritic cell markers on cultured neutrophils and its modulation by anti-apoptotic and pro-apoptotic compounds
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Park HY, Jin JO, Song MG, Park JI, Kwak JY
- KMID: 756066
- Exp Mol Med.
- 2007 Aug;39(4):439-449.
Neutrophils are also known to acquire the characteristics of dendritic cells (DCs) under the appropriate conditions. In this study, neutrophils were cultivated in vitro in the presence or absence of... -
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- Apoptosis of Skeletal Muscle on Steroid-Induced Myopathy in Rats
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Lee MJ, Lee JS, Lee MC
- KMID: 648306
- J Korean Med Sci.
- 2001 Aug;16(4):467-474.
- doi: 10.3346/jkms.2001.16.4.467
Recently apoptotic cell death has been reported in differentiated skeletal muscle, where apoptosis was generally assumed not to occur. To investigate whether apoptosis may contribute to the steroid-induced myopathy, rats... -
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- Expression of TRAIL Receptors in Cervical Cancer
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Chang SJ, Ryu HS, Kim MS, Joo HJ, Chang KH, Oh KS
- KMID: 2083747
- Korean J Gynecol Oncol Colposc.
- 2000 Mar;11(1):45-54.
Apoptosis is an intrinsic and fundamental biological process that plays a critical role in the normal development of multicellular organisms and in maintaining tissue homeostasis. Some of the well known... -
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- Changes of phospholipase D activity in TNF-alpha and anti-Fas/Apo1 monoclonal antibody induced apoptosis in HL-60 and A20 cells
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Kang JH, Shin IC, Han JS
- KMID: 754983
- Exp Mol Med.
- 1998 Mar;30(1):21-27.
The changes of phospholipase D (PLD) activity were investigated during the courses of apoptotic process induced by tumor necrosis factor (TNF)-alpha or anti-Fas/Apo1 antibody in human premyelocyte HL-60 and murine B cell... -
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- Analysis of Leukotriens Release and Fas/Fas Ligand Expression between Aspirin Sensitive and Non-Aspirin Sensitive Nasal Polyp Patients
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Na HJ, Do NY, Lee DY, Stankiewicz JA
- KMID: 2275624
- Korean J Otolaryngol-Head Neck Surg.
- 2001 Jan;44(1):41-46.
BACKGROUND AND OBJECTIVES: Fas and Fas ligand (Fas-L) interactions mediate apoptosis of eosinophils. It is possible that reduction of Fas/Fas-L or Fas-L expression on eosinophils could induce the eosinophilia seen... -
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- Serum Soluble Fas Levels of Patients with Aplastic Anemia
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Yun HJ, Kwag SH, Kang JH, Kim CH, Bae KB, Kim HS, Kim JS, Park SJ, Jo DY, Kim S
- KMID: 1537184
- Korean J Hematol.
- 2000 Feb;35(1):1-6.
BACKGROUND: Fas is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor family. Triggering of the Fas receptor pathway by its ligand results in apoptosis. Soluble Fas... -
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- Expression of Fas Ligand (FasL) in Normal Kidney and Experimental Acute Tubular Necrosis
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Kim WS, Noh JW, Park MH
- KMID: 2254245
- Korean J Nephrol.
- 2005 May;24(3):358-365.
BACKGROUND: Fas ligand (FasL) is a lethal cytokine that promotes apoptosis through activation of the Fas receptor. There are few studies on the expression of FasL in normal or injured... -
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- Effect of Interferon-r on Fas-mediated Apoptosis of Colon Cancer Cell Line HT-29
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Kang JK, Park IS, Kim WH, Ha SH
- KMID: 2084744
- Korean J Gastroenterol.
- 1997 May;29(5):620-631.
BACKGROUND/AIMS: Recent evidence suggests that alterations in regulation of apoptosis contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, degenerative diseases and inflammatory... -
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- Tissue Microarray Analysis of Fas and FasL Expressions in Human Non-small Cell Lung Carcinomas; with Reference to the p53 and bcl-2 Overexpressions
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Myong NH
- KMID: 1781759
- J Korean Med Sci.
- 2005 Oct;20(5):770-776.
- doi: 10.3346/jkms.2005.20.5.770
Lack of surface Fas expression is a main route for apoptotic resistance which is considered an important mechanism of tumorigenesis and tumor progression. Fas and FasL expressions in 110 non-small... -
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- The Expression of Fas Antigen and Apoptosis in Patients with Myelodysplastic Syndromes and Its Clinical Relevance
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Yu BW, Han KJ, Mok JO, Jeon JW, Park SK, Won JH, Baick SH, Suh WS, Hong DS, Lee DW, Park HS
- KMID: 2143383
- Korean J Hematol.
- 1997 Aug;32(2):256-265.
BACKGROUND: The myelodysplastic syndromes (MDS) are a group of acquired clonal hematopoietic disorders characterized by the peripheral cytopenias and hypercellular or normocellular dysplastic bone marrow. The event responsible for the... -
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