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Establishment of Antibody-dependant Cellular Cytotoxicity against Human Squamous Cell Carcinoma of Head and Neck and The Effect of Prostaglandin on Antibody-dependant Cellular Cytotoxicity

Kim CD, Byun SW, Hong SK

BACKGROUND: Head and neck squamous cell carcinoma(HNSCC) has been associated with host immunosuppression, including depressed T-lymphocyte and natural killer cell function. This immunosuppression has been shown to be most pronounced...
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Antibody Dependent Cell-Mediated Cytotoxicity in Patients with Urologic Cancers: A Change by Surgical Operation, Histologic Grades and Clinical Stages

Yoon MS, Lim SK, Kim DJ

  • KMID: 1911796
  • Korean J Urol.
  • 1982 Jun;23(3):283-291.
In an attempt to evaluate the immune competence of urologic cancer patients, antibody-dependent cell-mediated cytotoxicity (ADCC) were performed in thirty-four patients and same numbers of age and sex matched normal...
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Correlation of Natural Killer(NK) Cell Activity,Antibody Dependent Cellular Cytotoxicity(ADCC), and Serum Zinc Level in Behçet's Disease

Chung KY, Bang D, Lee SH, Lee ES, Lee S

BACKGROUND: Zinc which is widely used to treat Behcet's disease, is known to be an important modulator in various aspects of immunity including cell mediated immunity (CMI). CMI is suspected...
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The Effect of Prostaglandin and its Inhibitor on the Antibody - dependent Cellular Cytotoxicity Against Human Squamous Cell Carcinoma of the Head and Neck

Lee SJ, Kim CD, Chang KH, Kim KH, Yoon SJ, Lee SG, Lee HJ, Heo DS, Sung MW

  • KMID: 1548378
  • Korean J Immunol.
  • 1997 Dec;19(4):533-540.
The effects of chimeric monoclonal antibodies (cMAbs), prostaglandin E, (PGE,), and indomethacin (INDO) on antibody-dependent cellular cytotoxicity (ADCC) against human squamous cell carcinoma of head and neck (SCCHN) cell line...
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Natural killer activity and antibody-dependent cellular cytotoxicity in patients with primary lung cancer

Kim SK, Cho CH, Ahn CM, Jang SH, Lee YH, Kim SK, Chang J, Lee BK, Kim SJ, Youn JK

The NK activity and ADCC of peripheral blood mononuclear cell were examined to evaluate the contribution of ADCC and NK activity to host immune response against lung cancer. The NK...
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Anti-GD2 Monoclonal Antibody (dinutuximab) with GM-CSF, Interleukin 2, and Cis-retinoic Acid for the Treatment of High-risk Neuroblastoma

Jeon IS

Neuroblastoma, one of the most common solid tumors in early childhood, exhibits aberrant cell-surface glycosylation patterns. In neuroblastoma, disialoganglioside (GD2) is expressed homogeneously and abundantly on 100% of neuroblastoma cells....
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Donor Specific Antibody Negative Antibody-Mediated Rejection after ABO Incompatible Liver Transplantation

Lee B, Ahn S, Kim H, Han HS, Yoon YS, Cho JY, Choi YR

Antibody-mediated rejection (AMR) is a major complication after ABO-incompatible liver transplantation. According to the 2016 Banff Working Group on Liver Allograft Criteria for the diagnosis of acute AMR, a positive...
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Antibody-dependent Cell-mediated Cytotoxitity as a Prognostic Indicator in the Medical Treatment of Graves' Disease

Lee KW, Shin YG, Ro HR, Lee SK, Chung YS, Kim HM, Kim YJ, Hong EK, Chae BN

  • KMID: 1944213
  • J Korean Soc Endocrinol.
  • 1998 Dec;13(4):554-562.
BACKGROUND: The several forms of treatment of Graves disease-thyroidectomy, antithyroid drugs and radioiodide therapy-are in wide use now. But which therapy is best is a matter of debate. Some authors...
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Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity

Schmohl JU, Felices M, Oh F, Lenvik AJ, Lebeau AM, Panyam J, Miller JS, Vallera DA

PURPOSE: The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform,...
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Immunological Study on Autoimmune Postpartum Thyroiditis

Kim HM, Huh KB, Lee HC, Lim SK, Park K, Youn JK, Lee SY

Autoimmune postpartum thyroiditis (PPT) has been thought of as one of the organ-specific autoimmune diseases. The present study was designed to investigate whether the immunological changes during the postpartum period...
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A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model

Lee ES, Jeong MS, Singh R, Jung J, Yoon H, Min JK, Kim KH, Hong HJ

Intrahepatic cholangiocarcinoma (ICC), a malignant tumor derived from the intrahepatic bile duct epithelium, has a poor prognosis and is refractory to conventional chemotherapy and radiation therapy. Thus, there is an...
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Optimization of Large-Scale Expansion and Cryopreservation of Human Natural Killer Cells for Anti-Tumor Therapy

Min B, Choi H, Her JH, Jung MY, Kim HJ, Jung MY, Lee EK, Cho SY, Hwang YK, Shin EC

Allogeneic natural killer (NK) cell therapy is a potential therapeutic approach for a variety of solid tumors. We established an expansion method for large-scale production of highly purified and functionally...
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The Effects of Mesima-Ex, the Immunomodulator in Curatively Resected Gastric Cancer

Cho SH, Kim JH, Park BK, Park SJ, Ahn SH, Jung HC, Rho JK, Kim BS, Rho SH

  • KMID: 2059147
  • J Korean Cancer Assoc.
  • 1997 Oct;29(5):800-806.
PURPOSE: The Mesima-Ex is a kind of biologic response modifier, which is extracted from a mushroom called Phellinus linteus. Mesima-Ex consists of various chemical compounds which include protein bound polysaccharide,...
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In Vitro Study of Nonspecific Cellular Immunity in Rheumatoid Arthritis

Hong KP, Choi IH, Kim GS, Lee BK, Youn JK, Park BM

Nonspecific immune parameters such as natural killer(NK) activity, antibody-dependent cellular cytotoxicity(ADCC), production of leukocyte migration inhibitory factor(LlF) and levels of immune complex(IC) were assessed in 47 patients with rheumatoid arthritis...
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Functional Differentiation of HL-60 Cells by Dimethylsulfoxide and Phorbol 12-myristate 13-acetate

Kim HS, Kim KH, Kim GH, Seoh JY

  • KMID: 1946339
  • J Korean Pediatr Soc.
  • 1999 Mar;42(3):355-363.
PURPOSE: During hematopoietic differentiation of HL-60 cells by DMSO and PMA, we demonstrated functional changes of HL-60 cells-phagocytic activity, respiratory burst, antibody-dependent cell-mediated cytotoxicity(ADCC) and opsonophagocytic activity. METHODS: HL-60 cells(ATCC...
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Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma

Kim S, Chu J, Kim H, Han J

BACKGROUND: Cytologic diagnosis of pulmonary adenoid cystic carcinoma (AdCC) is frequently challenging and differential diagnosis with small cell carcinoma is often difficult. METHODS: Eleven cytologically diagnosed cases of pulmonary AdCC were...
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Possible roles of LFA-1 and Fc gamma receptors on the functional immaturities of cord blood polymorphonuclear leukocytes

Kim NA, Choi IH, Shin JS, Park SK, Kim NS, Choi DH, Kim SJ

The functional immaturity of PMNs is one of the major causes of overwhelming sepsis in newborns. In this study, we observed functions and surface markers of PMNs to investigate what...
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Phenotypic and Functional Differentiation of Promyelocytic Cell Line HL-60 by N-N-dimethylformamide

Kim KH, Seoh JY

  • KMID: 2335348
  • J Korean Pediatr Soc.
  • 1998 Apr;41(4):481-488.
PURPOSE: HL-60 is a promyelocytic cell line. Fc receptors and complement receptor 3 (CR3) play important role in the protective response of granulocytes and monocytes against microbial infection. We quantified...
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PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms

Lee JH, Kang HJ, Yoo CW, Park WS, Ryu JS, Jung YS, Choi SW, Park JY, Han N

BACKGROUND: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression...
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Fcr Receptor and Mac-1 Expression and Functional Differentiation of HL-60 Cells by All-trans Retinoic Acid

Kim HS, Kim KH, Kim GH, Seoh JY

  • KMID: 2142388
  • J Korean Pediatr Soc.
  • 1999 Apr;42(4):462-471.
PURPOSE: During differentiation of HL-60 cells by all-trans retinoic acid(ATRA), we analyzed the expression of Fcr receptors and Mac-1 by molecules of equivalent soluble fluorochromes(MESF) and functional studies. METHODS: HL-60...
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