- Microbiological Contamination of Laboratory Mice and Rats in Korea from 2007 to 2008
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Won YS, Kwon HJ, Kim SW, Han JT, Lee SB, Nam KH, Yoon WK, Kim KH, Moon OS, Kim HC
- KMID: 2312074
- Lab Anim Res.
- 2010 Sep;26(3):249-255.
In order to assess the microbiological contamination of laboratory mice and rats in Korea over the 2-year period from 2007 to 2008, we monitored animals housed in mouse and rat... -
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- Intrapancreatic ectopic splenic tissue found in a cloned miniature pig
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Koo OJ, Ha SK, Park SJ, Park HJ, Kim SJ, Kwon D, Kang JT, Moon JH, Park EJ, Jang G, Lee BC
- KMID: 2164536
- J Vet Sci.
- 2015 Jun;16(2):241-244.
- doi: 10.4142/jvs.2015.16.2.241
Somatic cell nuclear transfer (SCNT) is a cost-effective technique for producing transgenic pigs. However, abnormalities in the cloned pigs might prevent use these animals for clinical applications or disease modeling.... -
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- Calcium cycling proteins in heartfailure, cardiomyopathy and arrhythmias
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Minamisawa S, Sato Y, Cho MC
- KMID: 1097100
- Exp Mol Med.
- 2004 Jun;36(3):193-203.
A growing body of evidence, including studies using genetically engineered mouse models, has shown that Ca2+ cycling and Ca2+ -dependent signaling pathways play a pivotal role in cardiac hypertrophy and... -
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- Transgenesis for pig models
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Yum SY, Yoon KY, Lee CI, Lee BC, Jang G
- KMID: 2413124
- J Vet Sci.
- 2016 Sep;17(3):261-268.
- doi: 10.4142/jvs.2016.17.3.261
Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT).... -
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- Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors
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Kocahan S, DoÄŸan Z
- KMID: 2367656
- Clin Psychopharmacol Neurosci.
- 2017 Feb;15(1):1-8.
- doi: 10.9758/cpn.2017.15.1.1
The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment, neuronal death and the loss of synapses, all... -
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- Morphology and Distribution of the Vasoactive Intestinal Polypeptide (VIP)-Immunoreactive Amacrine Cells in the Mouse Retina
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Kang TH, Lee EJ, Kim IB
- KMID: 1610763
- Korean J Anat.
- 2003 Aug;36(4):283-289.
Vasoactive intestinal polypeptide (VIP) is a neuroactive substance that is widely expressed in both non-mammalian and mammalian retinas. In this study, we immunocytochemically identified and investigated the VIP-containing neurons in... -
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- Production of transgenic pigs using a pGFAP-CreER(T2)/EGFP(LoxP) inducible system for central nervous system disease models
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Hwang SU, Eun K, Yoon JD, Kim H, Hyun SH
- KMID: 2412134
- J Vet Sci.
- 2018 May;19(3):434-445.
- doi: 10.4142/jvs.2018.19.3.434
Transgenic (TG) pigs are important in biomedical research and are used in disease modeling, pharmaceutical toxicity testing, and regenerative medicine. In this study, we constructed two vector systems by using... -
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- Mouse Model for the Research of Sinusitis Induced Olfactory Dysfunction
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Jung YG
- KMID: 2135821
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2015 Dec;58(12):815-821.
- doi: 10.3342/kjorl-hns.2015.58.12.815
Olfactory dysfunction is one of the most debilitating problem in chronic rhinosinusitis (CRS) patients, and exact mechanism underlying sinusitis induced olfactory dysfunction was not fully understood. In vivo manipulation for... -
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- Post-mortem re-cloning of a transgenic red fluorescent protein dog
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Hong SG, Koo OJ, Oh HJ, Park JE, Kim M, Kim GA, Park EJ, Jang G, Lee BC
- KMID: 1365026
- J Vet Sci.
- 2011 Dec;12(4):405-407.
- doi: 10.4142/jvs.2011.12.4.405
Recently, the world's first transgenic dogs were produced by somatic cell nuclear transfer. However, cellular senescence is a major limiting factor for producing more advanced transgenic dogs. To overcome this... -
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- Successful surgical correction of anal atresia in a transgenic cloned piglet
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Lee GS, Kim HS, Lee SH, Kim DY, Seo KM, Hyun SH, Kang SK, Lee BC, Hwang WS
- KMID: 1091207
- J Vet Sci.
- 2005 Sep;6(3):243-245.
Inbred strains of pig become indispensable for a wide range of biological studies. In biomedical science, it is generally accepted that somatic cell nuclear transfer(SCNT)technology with inbreed strain of pig... -
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- Coordinated change of a ratio of methylated H3-Iysine 4 or acetylated H3 to acetylated H4 and DNA methylation is associated with tissue-specific gene expression in cloned pig
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Kang JK, Park KW, Chung YG, You JS, Kim YK, Lee SH, Hong SP, Choi KM, Heo KN, Seol JG, Lee JH, Jin DI, Park CS, Seo JS, Lee HW, Han JW
- KMID: 1103684
- Exp Mol Med.
- 2007 Feb;39(1):84-96.
Various cell types in higher multicellular organisms are genetically homogenous, but are functionally and morphologically heterogeneous due to the differential expression of genes during development, which appears to be controlled... -
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- Polydeoxyribonucleotides Improve Diabetic Wound Healing in Mouse Animal Model for Experimental Validation
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Kwon TR, Han SW, Kim JH, Lee BC, Kim JM, Hong JY, Kim BJ
- KMID: 2451477
- Ann Dermatol.
- 2019 Aug;31(4):403-413.
- doi: 10.5021/ad.2019.31.4.403
BACKGROUND: Wound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of... -
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- Functions and physiological roles of two types of estrogen receptors, ERalpha and ERbeta, identified by estrogen receptor knockout mouse
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Lee HR, Kim TH, Choi KC
- KMID: 1436696
- Lab Anim Res.
- 2012 Jun;28(2):71-76.
- doi: 10.5625/lar.2012.28.2.71
Estrogens, a class of steroid hormones, regulate the growth, development, and physiology of the human reproductive system. Estrogens also involve in the neuroendocrine, skeletal, adipogenesis, and cardiovascular systems. Estrogen signaling... -
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- Autologous somatic cell nuclear transfer in pigs using recipient oocytes and donor cells from the same animal
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Lee E, Song K
- KMID: 1106223
- J Vet Sci.
- 2007 Dec;8(4):415-421.
- doi: 10.4142/jvs.2007.8.4.415
The objective of the present study was to examine the feasibility of the production of autologous porcine somatic cell nuclear transfer (SCNT) blastocysts using oocytes and donor cells from slaughtered... -
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- Laparoscopy vs. laparotomy for embryo transfer to produce transgenic goats (Capra hircus)
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Shin ST, Jang SK, Yang HS, Lee OK, Shim YH, Choi WI, Lee DS, Lee GS, Cho JK, Lee YW
- KMID: 1102960
- J Vet Sci.
- 2008 Mar;9(1):103-107.
- doi: 10.4142/jvs.2008.9.1.103
This study was performed to produce transgenic Korean native goat (Capra hircus) by laparoscopic embryo transfer (ET) to overcome the limitations of ET performed by laparotomy. Transgenic embryos were produced... -
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- microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish
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Kim CW, Han JH, Wu L, Choi JY
- KMID: 2418861
- Yonsei Med J.
- 2018 Jan;59(1):141-147.
- doi: 10.3349/ymj.2018.59.1.141
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the... -
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- Effect of Oxygen on Photoreceptor Degeneration in Retinal Degeneration Mice
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Choi MY, Heo JH, Auh SJ, Yu YS
- KMID: 2205925
- J Korean Ophthalmol Soc.
- 2000 Sep;41(9):1824-1833.
There is still no effective treatment for retinal degenerative diseases, in which the loss of photoreceptor cells causes visual loss and eventually blindness. Despite the current studies show that intraocular... -
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- Establishment of a surgically induced cryptorchidism canine recipient model for spermatogonial stem cell transplantation
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Lee WY, Lee R, Song H, Hur TY, Lee S, Ahn J, Jhun H
- KMID: 2362918
- Lab Anim Res.
- 2016 Dec;32(4):257-266.
- doi: 10.5625/lar.2016.32.4.257
Transplantation of spermatogonial stem cells (SSCs) in experimental animal models has been used to study germ line stem cell biology and to produce transgenic animals. The species-specific recipient model preparation... -
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- Improved development of somatic cell cloned bovine embryos by a mammary gland epithelia cells in vitro model
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He XY, Ma LB, He XN, Si WT, Zheng YM
- KMID: 2413163
- J Vet Sci.
- 2016 Jun;17(2):145-152.
- doi: 10.4142/jvs.2016.17.2.145
Previous studies have established a bovine mammary gland epithelia cells in vitro model by the adenovirus-mediated telomerase (hTERT-bMGEs). The present study was conducted to confirm whether hTERT-bMGEs were effective target... -
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- Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos
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Cho J, Kang S, Lee BC
- KMID: 1784643
- J Vet Sci.
- 2014 Jun;15(2):225-231.
- doi: 10.4142/jvs.2014.15.2.225
This study was conducted to investigate the expression of three genes related to early embryonic development in bovine transgenic cloned embryos. To accomplish this, development of bovine transgenic somatic cell... -
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