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A case of acute myocardial infarction associated with amphetamine abuse

Lee SH, Lee KE, Lee KJ, Kim SW, Kim TH, Kim CJ, Ryu WS

  • KMID: 2257831
  • Korean J Med.
  • 2007 Oct;73(4):428-431.
Acute myocardial infarction is a rarely reported complication of amphetamine abuse. We report here on a case of a 39-year-old man who presented with cardiac enzyme patterns, a clinical history...
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A Case of Acute Renal Failure Caused by Amphetamine-Associated Rhabdomyolysis

Kim TH, Kim HW, Kim BR, Kim JW, Park JJ, Sohn I, Cho YS

  • KMID: 2254954
  • Korean J Nephrol.
  • 2000 May;19(3):532-536.
Amphetamine toxicity is well known in western countries since several decades ago. Taken in excessive amount, amphetamine causes systemic symptoms such as hyperpyrexia, tachycardia, hyperkinesia, delirium, seizure and circulatory collapse....
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Amphetamine-induced ERM Proteins Phosphorylation Is through PKCbeta Activation in PC12 Cells

Jeong HJ, Kim JH, Jeon S

Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation...
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Repeated Exposure to beta-phenylethylamine Produces Locomotor Sensitization to Amphetamine, but Not Vice Versa, in the Rat

Park HK, Na JC, Jang JK, Kim JH

Repeated administration of amphetamine (AMPH) produces behavioral sensitization, a proposed model for the escalation of drug use characteristic of human addicts. beta-Phenylethylamine (PEA) is an endogenous trace amine found in...
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Effect of heat shock protein 72 on the generation of reperfusion arrhythmias

Chang MJ, Na HS, Nam HJ, Pyun KS, Hong SK

  • KMID: 1917025
  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):319-324.
The causal relationship between heat shock protein (HSP) and second window of cardioprotective effect is still undetermined. In the present study, we assessed whether HSP-producing substances, amphetamine and ketamine, afforded protection against reperfusion-induced...
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Regulation of phosphorylated cAMP response element-binding protein, Fos-related antigen and FosB expression by dopamine agonists in rat striatum

Choe ES, Kim JY

  • KMID: 2071569
  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):299-305.
Activation of D1-like dopamine receptors by psychostimulants, such as amphetamine, upregulates the expression of immediate early gene and opioid peptide gene in the striatum. The genomic changes are regulated by phosphorylated transcription factors...
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Two Cases of Psychotic Disorder Following Phendimetrazine Use

Lee JM, Lee KU, Jhoo JH, Park JI

  • KMID: 2287386
  • Korean J Psychopharmacol.
  • 2010 Apr;21(2):95-98.
Phendimetrazine is a medication currently being used to help patients with weight loss. It shares a chemical structure with amphetamines. As such, it shares some of the same toxicities, which...
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D-Amphetamine Causes Dual Actions on Catecholamine Release from the Rat Adrenal Medulla

Lim GH, Na GM, Min SY, Seo YS, Park CW, Lim DY

  • KMID: 2285309
  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):45-53.
The present study was designed to examine the effect of d-amphetamine on CA release from the isolated perfused model of the rat adrenal gland, and to establish its mechanism of...
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Effect of Repeated Graft of Fetal Mesencephalic Cells in 6-Hydroxydopamine Rat Model of Hemiparkinsonism

Han DH, Oh CW, Kim YS, Park CW

  • KMID: 1956071
  • J Korean Neurosurg Soc.
  • 1999 Sep;28(9):1249-1256.
OBJECTIVE: In this experimental study, authors evaluated the effect of repeated graft of the fetal midbrain cells on rat model of hemiparkinsonism. MATERIALS AND METHODS: Following injection of the 6-hydroxydopamine into...
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Aberrant Thalamocortical Synchrony Associated with Behavioral Manifestations in Git1-/- Mice

Mah W

Cross-talk between the thalamus and cortex has been implicated in attention but its pathogenic role in attention-deficit/hyperactivity disorder (ADHD) remains unknown. Here, I demonstrate that Git1-/- mice, previously proposed as...
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Does HSP70 Induced by Amphetamine Prevent Renal Ischemia/Reperfusion Injury in Rat?

Jo YI, Na HS, Back SK, Cho SC, Kim KS, Choi YS, Song JO

  • KMID: 1989562
  • Korean J Nephrol.
  • 2004 Jan;23(1):12-21.
BACKGROUND: Heat shock proteins (HSPs) induced by variable kinds of stress produce tolerance to a variety of adverse conditions. However, the protective effect of HSP on ischemia/reperfusion injury (I/R injury)...
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Amphetamine-Like Weight Reduction Drug Induced Acute Cardiomyopathy with Left Ventricular Thrombosis

Kim JM, Ryu SK, Choi JW, Shin DG, Lee YH, Kang HR, Chae WY, Park JS

A 37-year-old female patient admitted due to dyspnea on exertion and peripheral edema. For one and a half years, the patient had been taking various drugs and supplements to reduce...
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Recurrent Psychosis after Phentermine Administration in a Young Female: A Case Report

Jo HS, Wang SM, Kim JJ

Phentermine is a sympathomimetic amine, like amphetamine, which is one of the most often prescribed drugs for weight loss. Although exact mechanism of phentermine causing psychosis is still not clear,...
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Behavioral and Immunohistochemical Characterization of 6-Hydroxydopamine Induced Rat Models of Parkinson's Disease

Chang UK, Chung CK, Oh CW, Han DH, Kim HJ, Cho SS, Kim YS, Park CW

  • KMID: 1955634
  • J Korean Neurosurg Soc.
  • 1998 Feb;27(2):139-145.
There are several methods with which 6-hydroxy-dopamine is injected into the nigrostriatal pathway in rats for making models of Parkinson's disease. One is a complete lesion model in which A9...
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A Case of Transient Psychosis after Sustained Release Bupropion Overdose

Na KS, Lee SI, Jung HY

  • KMID: 2287494
  • Korean J Psychopharmacol.
  • 2011 Jul;22(3):161-165.
Bupropion is a unique antidepressant with enhancing both noradrenergic and dopaminergic neurotransmission without altering serotonergic system. Given its pharmacodynamics and structural similarity to amphetamine, the possibility of bupropionrelated psychosis has...
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Evaluation of the Abuse Potential of Novel Amphetamine Derivatives with Modifications on the Amine (NBNA) and Phenyl (EDA, PMEA, 2-APN) Sites

Custodio R, Botanas CJ, Yoon SS, de la Peña JB, dela Peña IJ, Kim M, Woo T, Seo JW, Jang CG, Kwon YH, Kim NY, Lee YS, Kim HJ, Cheong JH

Recently, there has been a rise in the number of amphetamine derivatives that serve as substitutes for controlled substances (e.g. amphetamine and methamphetamine) on the global illegal drug market. These...
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Anti-Obesity Drugs: A Review about Their Effects and Safety

Kang JG, Park CY

The current recommendations for the treatment of obese people include increased physical activity and reduced calories intake. When the behavioral approach is not sufficient, a pharmacologic treatment is recommended. In...
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Drug Abuse and Psychosis: New Insights into Drug-induced Psychosis

Ham S, Kim TK, Chung S, Im HI

Addictive drug use or prescribed medicine abuse can cause psychosis. Some representative symptoms frequently elicited by patients with psychosis are hallucination, anhedonia, and disrupted executive functions. These psychoses are categorized...
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Practical Use and Risk of Modafinil, a Novel Waking Drug

Kim D

  • KMID: 2380174
  • Environ Health Toxicol.
  • 2012 ;27(1):e2012007.
OBJECTIVES: Modafinil is a waking drug prescribed to narcolepsy patients, but its usage among healthy individuals is increasing to enhance their alertness or to mitigate fatigue. This study was conducted...
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Revisiting History of Treatment of Attention Deficit Hyperactivity Disorder : Pharmacologic Approach

Bahn GH, Hong M, Lee YJ, Han JH, Oh SH

  • KMID: 2250772
  • Korean J Biol Psychiatry.
  • 2014 May;21(2):37-48.
Besides from medical data, the patients who were previously called as attention disorder, mental instability, moral imbeciles, or moral defectives, can also be identified by exploring literatures and historical figures....
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