- The role of mitochondrial aldehyde dehydrogenase (ALDH) deficiency in Koreans with alcoholic liver disease
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Byun KS, Kwon SY, Park SH, Koo YS, Yeon JE, Kim JS, Bak YT, Kim JH, Kim JG, Lee CH
- KMID: 1698309
- Korean J Med.
- 1993 Sep;45(3):328-336.
No abstract available. -
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- A Case of Sjogren-Larsson Syndrome
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Lee JH, Lee J, Choi GS, Koo SW, Kim YK
- KMID: 2230539
- Korean J Dermatol.
- 1998 Dec;36(6):1078-1082.
Sjogren-Larsson syndrome is a rare autosomal recessive neurocutaneous disorder due to a deficiency of the fatty aldehyde dehydrogenase. It consists of ichthyosis, spastic di- or quardriplegia and mental retardation. We... -
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- Analysis of Breath Alcohol Degradation and Alcohol Metabolic Enzymes in a Korean Male Population
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Lee SD, Lee YS, Yoo SH
- KMID: 2082729
- Korean J Leg Med.
- 2009 May;33(1):60-64.
To evaluate the concentration-time profiles of breath ethanol in degradation phase in proportion to the amount of alcohol, we carried out the controlled drinking study for 24 healthy males. Studies... -
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- Epileptic Seizure Due to Disulfiram Treatment
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Erensoy H, Sargin AE
- KMID: 2469487
- Korean J Fam Med.
- 2019 Nov;40(6):406-408.
- doi: 10.4082/kjfm.18.0014
Disulfiram has been used for the treatment of alcohol dependence for nearly 65 years and is approved by the Food and Drug Administration. It causes negative reinforcement by accumulating toxic... -
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- Mitochondrial Aldehyde Dehydrogenase Precursor Protein and 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2: Two-dimensional Electrophoretic Expressed Protein in the Liver of Acute Alcoholic Abuse
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Yoo SH
- KMID: 2082730
- Korean J Leg Med.
- 2009 May;33(1):65-69.
To study alcohol-related expressed proteins across postmortem livers, human liver tissues from two cadaveric subjects died of acute alcohol abuse and myocardialinfarct were compared. Liver tissues were separated by means... -
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- Genetic Frequencies of Aldehyde Dehydrogenase 2 in Korean patients with Alcohol Dependence
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Paik IH, Lee C, Lee SJ, Lee CU, Kim JJ, Jun TY, Han SI, Hahm W
- KMID: 2017702
- J Korean Neuropsychiatr Assoc.
- 1998 Jan;37(1):149-158.
OBJECTIVE: This study was designed to investigate the association of ALDH2 genetic types with the risk and clinical variables of alcohol dependence in Korean patients. METHODS: ALDH2 genotypes were typed with... -
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- Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis
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He L, Deng T, Luo H
- KMID: 2374118
- Yonsei Med J.
- 2016 Jul;57(4):879-884.
- doi: 10.3349/ymj.2016.57.4.879
PURPOSE: The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a... -
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- Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes
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Kim YH, Shin MJ
- KMID: 1081461
- Exp Mol Med.
- 2002 May;34(2):123-130.
Membrane-associated cytotoxicity induced by hydrophobic bile salts is a major contributing factor leading to liver diseases. Administration of ursodeoxycholate reduces serum liver enzymes in chronic liver diseases but the nature... -
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- Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population
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Seok H, Yoo KH, Kim YO, Chung JH
- KMID: 2233004
- Int Neurourol J.
- 2013 Dec;17(4):168-173.
PURPOSE: Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH)... -
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- Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
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Shin MJ, Cho Y, Davey Smith G
- KMID: 2419072
- Yonsei Med J.
- 2017 Jul;58(4):689-696.
- doi: 10.3349/ymj.2017.58.4.689
Alcohol consumption is a serious health issue in Korea in terms of the amount consumed and the behavior related to its consumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme... -
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- Inhibitor of DNA-binding 4 contributes to the maintenance and expansion of cancer stem cells in 4T1 mouse mammary cancer cell line
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Park SJ, Kim RJ, Nam JS
- KMID: 1444966
- Lab Anim Res.
- 2011 Dec;27(4):333-338.
- doi: 10.5625/lar.2011.27.4.333
The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer. CSC-targeted therapies may prevent cancer relapse and provide more effective treatment. The expression of aldehyde dehydrogenase... -
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- The Extract of Limonium tetragonum Protected Liver against Acute Alcohol Toxicity by Enhancing Ethanol Metabolism and Antioxidant Enzyme Activities
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Kim NH, Sung SH, Heo JD, Jeong EJ
- KMID: 2409600
- Nat Prod Sci.
- 2015 Mar;21(1):54-58.
- doi: 10.0000/nps.2015.21.1.54
The protective effect of EtOAc fraction of Limonium tetragonum extract (EALT) against alcoholinduced hepatotoxicity was assessed following acute ethanol intoxication in Spraque-Dawley rats. EALT (200 mg/kg p.o.) was administrated once... -
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- The Expression of Aldehyde Dehydrogenase Family in Breast Cancer
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Qiu Y, Pu T, Li L, Cheng F, Lu C, Sun L, Teng X, Ye F, Bu H
- KMID: 2353084
- J Breast Cancer.
- 2014 Mar;17(1):54-60.
PURPOSE: It is widely accepted that aldehyde dehydrogenase (ALDH) activity is a signature of breast cancer stem cells, and high activity has been reported to be associated with poor clinical... -
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- Clinicopathologic Characteristics of Breast Cancer Stem Cells Identified on the Basis of Aldehyde Dehydrogenase 1 Expression
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Kim YS, Jung MJ, Ryu DW, Lee CH
- KMID: 2353066
- J Breast Cancer.
- 2014 Jun;17(2):121-128.
PURPOSE: Breast cancer displays varying molecular and clinical features. The ability to form breast tumors has been shown by several studies with aldehyde dehydrogenase 1 (ALDH1) positive cells. The aim... -
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- Effective Keratocyte Culture Using Amniotic Membrane Matrix and Differentiation of Mesenchymal Stem Cells
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Park SH, Chun YS, Kim JC
- KMID: 2337906
- J Korean Ophthalmol Soc.
- 2010 Dec;51(12):1652-1658.
PURPOSE: To investigate the characteristics of cultured rabbit corneal keratocytes in vitro and evaluate the possibility of differentiation of mesenchymal stem cells to keratocytes using the keratocyte conditioned medium (KCM). METHODS:... -
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- Hypotension Caused by a Disulfiram-Alcohol Reaction
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Lee SL, Ryu SY, Kim HY
- KMID: 2194052
- J Korean Soc Emerg Med.
- 2002 Dec;13(4):575-577.
Disulfiram, or antabuse, is used in the treatment of chronic alcoholism since it causes an unpleasant aversive reaction to alcohol. It works by inactivating hepatic aldehyde dehydrogenase, leading to a... -
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- A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma
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Tavasoli A, Sayyahfar , Behnam B
- KMID: 2353158
- Korean J Pediatr.
- 2016 Jun;59(6):276-279.
- doi: 10.3345/kjp.2016.59.6.276
Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive neurocutaneous disorder with worldwide incidence of 0.4 per 100,000 people. It is characterized by the triad of congenital ichthyosis, spastic diplegia or... -
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- Association of Genetic Polymorphisms of Aldehyde Dehydrogenase II and CYP2E1 and Clinical Characteristics of Patients with Alcohol Dependence
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Chung IW, Kim YR, Chi KH, Kim H
- KMID: 2202795
- J Korean Soc Biol Psychiatry.
- 2002 Jul;9(1):42-49.
OBJECTIVE: This study was to explore the relation of genetic polymorphisms of ALDH2 and CYP2E1 to clinical characteristics of alcoholic patients and alcohol induced liver damage. METHODS: The genotype and allele... -
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- The Genetic Factors Affecting Drinking Behaviors of Korean Young Adults with Variant Aldehyde Dehydrogenase 2 Genotype
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Kim SK, Lee SI, Shin CJ, Son JW, Ju G
- KMID: 2315914
- Psychiatry Investig.
- 2010 Dec;7(4):270-277.
OBJECTIVE: We determined whether aldehyde dehydrogenase 2 (ALDH2) activity alters the way in which drinking behaviors are affected by gene polymorphisms of other alcohol-metabolizing enzymes and serotonin-related proteins. METHODS: Through a... -
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- Effects of Chongkukjang Intake on Lipid Metabolism and Liver Function in Ethanol Consumed Rats
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Lee EH, Chyun JH
- KMID: 2260667
- Korean J Nutr.
- 2007 Dec;40(8):684-692.
This study was performed to investigate the effect of chongkukjang intake on lipid metabolism and liver function in ethanol consumed rats. Twenty one Sprague-Dawley male rats aging 4 weeks old... -
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