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Clinical Features of Multiple Acyl-CoA Dehydrogenase Deficiency With ETFDH Variants in the First Korean Cases

Kim YJ, Ko JM, Song J, Lee KA

No abstract available.
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Mitochondrial Aldehyde Dehydrogenase Precursor Protein and 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2: Two-dimensional Electrophoretic Expressed Protein in the Liver of Acute Alcoholic Abuse

Yoo SH

  • KMID: 2082730
  • Korean J Leg Med.
  • 2009 May;33(1):65-69.
To study alcohol-related expressed proteins across postmortem livers, human liver tissues from two cadaveric subjects died of acute alcohol abuse and myocardialinfarct were compared. Liver tissues were separated by means...
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Physiological Functionality and Enzyme Activity of Biomass from Pichia anomala Grown on Ginseng-Steaming Effluent

Kim NM, So SH, Lee SG, Song JE, Seo DS, Lee JS

A novel biomass was prepared from Pichia anomala KCCM 11473, which grew well in ginseng-steaming effluent (GSE), and its physiological functionalities and enzyme activities were determined. When the strain was...
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Intractable metabolic acidosis in a child with propionic acidemia undergoing liver transplantation: a case report

Ryu J, Shin YH, Ko JS, Gwak MS, Kim GS

Propionic acidemia (PA) is a rare autosomal recessive disorder of metabolism caused by deficient activity of the mitochondrial enzyme propionyl-CoA carboxylase. The clinical manifestations are metabolic acidosis, poor feeding, lethargy,...
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Studies on Platelet Aggregate Ratio and Plasma Free Fatty Acid Level in Myocardial Infarction and Cerebral Thrombosis

Koh YB, Lee YW

Platelet aggregate ratio and fasting plasma free fatty acid level were measured to evaluate their roles and correlation as the contributing factors leading to clinical events of atherosclerotic vascular disease....
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Neuroprotective effects of L-carnitine against oxygen-glucose deprivation in rat primary cortical neurons

Kim YJ, Kim SY, Sung DK, Chang YS, Park WS

PURPOSE: Hypoxic-ischemic encephalopathy is an important cause of neonatal mortality, as this brain injury disrupts normal mitochondrial respiratory activity. Carnitine plays an essential role in mitochondrial fatty acid transport and...
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Protective Effect of PGC-1 on Lipid Overload-induced Apoptosis in Vascular Endothelial Cell

Koh EH, Kim YM, Kim HJ, Lee WJ, Won JC, Kim MS, Lee KU, Park JY

BACKGROUND: Fatty acids contribute to endothelial cell dysfunction and apoptosis by inducing accumulation of long chain fatty acyl CoA (LCAC), which increases oxidative stress in vascular endothelial cells. Forced expression...
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Chronic intermittent form of isovaleric aciduria in a 2-year-old boy

Cho JM, Lee BH, Kim GH, Kim YM, Choi JH, Yoo HW

Isovaleric aciduria (IVA) is caused by an autosomal recessive deficiency of isovaleryl-CoA dehydrogenase (IVD). IVA presents either in the neonatal period as an acute episode of fulminant metabolic acidosis, which...
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Organic acidemias in Korea

Lee HJ

  • KMID: 2168073
  • Hanyang Med Rev.
  • 2005 Aug;25(3):49-64.
Since we started organic acid analysis in July 1997, we have collected data about organic acidemias in Korea. The data presented herein constitute our 3 years experience in organic acid...
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Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice

Park MY, Mun ST

  • KMID: 2313683
  • Nutr Res Pract.
  • 2013 Aug;7(4):294-301.
In this study, we examined the hepatic anti-steatosis activity of carnosic acid (CA), a phenolic compound of rosemary (Rosmarinus officinalis) leaves, as well as its possible mechanism of action, in...
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HMG CoA Reductase Inhibitors Inhibit HCV RNA Replication of HCV Genotype 1b but Not 2a

Chang KS, Jo HJ

Replication of hepatitis C virus (HCV) is regulated by statin, one of 3-hydroxy-3-methylglutaryl CoA reducatase (HMG CoA reductase) inhibitors that block mevalonate pathway and cholesterol biosyntheis, which has been used...
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Effects of Simvastatin on the Growth and Invasion of Anaplastic Thyroid Cancer Cells Lines

Choi HJ, Kim TY, Kim EY, Kim WG, Kim WB, Shong YK

  • KMID: 2333260
  • J Korean Endocr Soc.
  • 2008 Aug;23(4):238-244.
BACKGROUND: Anaplastic thyroid carcinoma has grave prognosis with most patient dying within 6 months of diagnosis. 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors have been reported to have an anticancer effect in...
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Effect of Young Barley Leaf on Lipid Contents and Hepatic Lipid-Regulating Enzyme Activities in Mice Fed High-Fat Diet

Yang EJ, Cho YS, Choi MS, Woo MN, Kim MJ, Shon MY, Lee MK

  • KMID: 2264044
  • Korean J Nutr.
  • 2009 Jan;42(1):14-22.
This study was conducted to investigate the effects of powdered young barley leaf and its water extract on body weight and lipid metabolism in high-fat fed mice. Male mice were...
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Anti-diabetic activities of catalpol in db/db mice

Bao Q, Shen X, Qian L, Gong C, Nie M, Dong Y

The objective was to investigate the hypoglycemic action of catalpol in spontaneous diabetes db/db mice. 40 db/db mice were randomly divided into fi ve groups: model control gourp; db/db plus...
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Factors Affecting Production of C-reactive Protein in Vascular Smooth Muscle Cells

Kim SJ, Ryu DR, Kang DH, Choi KB

  • KMID: 1465933
  • Korean J Nephrol.
  • 2009 May;28(3):173-179.
PURPOSE:The stenosis of vascular access for hemodialysis is caused by neointimal hyperplasia with the proliferation of vascular smooth muscle cells (SMC) as a prominent feature. C-reactive protein (CRP) is known...
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The Effects of Combined Treatment with an HMG-CoA Reductase Inhibitor and PPARgamma Agonist on the Activation of Rat Pancreatic Stellate Cells

Lee BJ, Lee HS, Kim CD, Jung SW, Seo YS, Kim YS, Jeen YT, Chun HJ, Um SH, Lee SW, Choi JH, Ryu HS

  • KMID: 2284274
  • Gut Liver.
  • 2012 Apr;6(2):262-269.
BACKGROUND/AIMS: Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) and peroxisome proliferator-activated receptor gamma (PPARgamma) ligands can modulate cellular differentiation, proliferation, and apoptosis through various pathways. It has been shown that HMG-CoA...
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Inherited metabolic diseases in the urine organic acid analysis of complex febrile seizure patients

Cheong HJ, Kim HR, Lee SS, Bae EJ, Park WI, Lee HJ, Choi HC

PURPOSE: Seizure associated with fever may indicate the presence of underlying inherited metabolic diseases. The present study was performed to investigate the presence of underlying metabolic diseases in patients with...
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Organic Acidemias in Korea: Three Years Experience of Organic Acid Analysis

Choi YK, Kim ES, Bae EJ, Park WI, Lee KJ, Lee HJ

  • KMID: 2335686
  • J Korean Pediatr Soc.
  • 2002 Nov;45(11):1346-1358.
PURPOSE: We have done this retrospective study to know the relative incidences and clinical manifestations of organic acidopathies in Korea. METHODS: The results of quantitative organic acid analysis of 1,125...
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Organic acidemias in Korea: Eight years experience of organic acid analysis

Bang JS, Lim SH, Lee KH, Bae EJ, Park WI, Lee HJ

PURPOSE: We have done this retrospective study to know the relative incidence and clinical manifestations of organic acidopathies in Korea during 8 years(from Jul. 1997 to May 2005). This results...
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