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Prevalence and Characterization of Actinobacillus pleuropneumoniae Isolated from Korean Pigs

Lee KE, Choi HW, Kim HH, Song JY, Yang DK

Actinobacillus pleuropneumoniae causes porcine pleuropneumoniae which is one of severe threats to the swine industry. In total, 54 strains of Actinobacillus pleuropneumoniae were isolated from 443 pigs between 2012 and...
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Serotype and antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolates from pigs in Korea

Jung JY, Jang H

  • KMID: 1435831
  • Korean J Vet Res.
  • 2012 Sep;52(3):177-181.
Actinobacillus (A.) pleuropneumoniae is the causative agent of pleuropneumonia which is one of the most important respiratory diseases in pigs worldwide. A total of 32 A. pleuropneumoniae isolates from diseased...
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Generation of transgenic corn-derived Actinobacillus pleuropneumoniae ApxIIA fused with the cholera toxin B subunit as a vaccine candidate

Shin MK, Jung MH, Lee WJ, Choi PS, Jang YS, Yoo HS

Corn, one of the most important forage crops worldwide, has proven to be a useful expression vehicle due to the availability of established transformation procedures for this well-studied plant. The...
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Development of Actinobacillus pleuropneumoniae ApxI, ApxII, and ApxIII-specific ELISA methods for evaluation of vaccine efficiency

Jung M, Won H, Shin MK, Oh MW, Shim S, Yoon I, Yoo HS

Among various vaccines against Actinobacillus pleuropneumoniae, subunit vaccines using recombinant proteins of ApxI, ApxII, and ApxIII as vaccine antigens have shown good efficacy in terms of safety and protection. Therefore,...
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In silico analysis of putative drug and vaccine targets of the metabolic pathways of Actinobacillus pleuropneumoniae using a subtractive/comparative genomics approach

Birhanu BT, Lee SJ, Park NH, Song JB, Park SC

Actinobacillus pleuropneumoniae is a Gram-negative bacterium that resides in the respiratory tract of pigs and causes porcine respiratory disease complex, which leads to significant losses in the pig industry worldwide....
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Expression of apxIA of Actinobacillus pleuropneumoniae in Saccharomyces cerevisiae

Shin SJ, Bae JL, Cho YW, Yang MS, Kim DH, Jang YS, Yoo HS

  • KMID: 1089601
  • J Vet Sci.
  • 2003 Dec;4(3):225-228.
Actinobacillus pleuropneumoniae is an important primary pathogen in pigs, in which it causes a highly contagious pleuropneumoniae. In our previous study, apxIA gene amplified from A. pleuropneumoniae Korean isolate by...
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Elucidating the role of ApxI in hemolysis and cellular damage by using a novel apxIA mutant of Actinobacillus pleuropneumoniae serotype 10

Chang NY, Chen ZW, Chen TH, Liao JW, Lin CC, Chien MS, Lee WC, Lin JH, Hsuan SL

Exotoxins produced by Actinobacillus (A.) pleuropneumoniae (Apx) play major roles in the pathogenesis of pleuropneumonia in swine. This study investigated the role of ApxI in hemolysis and cellular damage using...
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Enhancement of protective immune responses by oral vaccination with Saccharomyces cerevisiae expressing recombinant Actinobacillus pleuropneumoniae ApxIA or ApxIIA in mice

Shin SJ, Shin SW, Kang ML, Lee DY, Yang MS, Jang YS, Yoo HS

We previously induced protective immune response by oral immunization with yeast expressing the ApxIIA antigen. The ApxI antigen is also an important factor in the protection against Actinobacillus pleuropneumoniae serotype...
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A predictive model for the level of sIgA based on IgG levels following the oral administration of antigens expressed in Sacchromyces cerevisiae

Shin SJ, Shin SW, Choi EJ, Lee DY, Ahn JM, Yang MS, Jang YS, Yoo HS

  • KMID: 1090765
  • J Vet Sci.
  • 2005 Dec;6(4):305-309.
Oral vaccination may be the most efficient way of inducing an immune response at the remote mucosal site through the common mucosal immune network. Antigenspecific secretory IgA (sIgA) is the...
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Effective methods for the production of immunoglobulin Y using immunogens of Bordetella bronchiseptica, Pasteurella multocida and Actinobacillus pleuropneumoniae

Shin NR, Choi IS, Kim JM, Hur W, Yoo HS

  • KMID: 1101574
  • J Vet Sci.
  • 2002 Mar;3(1):47-57.
Swine respiratory diseases induce severe economic losses in the swine industry worldwide. Several methods have been developed and applied to control these diseases. However, there are still problems of disease...
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