- Reversal Effects of Neostigmine, Edrophonium and 4-aminopyridine of Verapamil Pretreatment on Pipecuronium Induced Neuromuscular Blockade in Rat-Hemidiaphragm
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Park JW, Yoon SM
- KMID: 2091121
- Korean J Anesthesiol.
- 1997 Aug;33(2):228-236.
- doi: 10.4097/kjae.1997.33.2.228
BACKGROUND: It has been shown that L-type calcium channel blockers increase the muscle relaxation effects of non-depolarizing neuromuscular blocking agents whereas the potentiated neuromuscular blocking effects by L-type calcium channel... -
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- The Effect of 4-Aminopyridine with Anticholinesterases on MgSO4-Rocuronium-Induced Neuromuscular Blockade in Vitro
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Hwang KH, Cho MH, Hong ST, Park W, Kim SY
- KMID: 1936300
- Korean J Anesthesiol.
- 2000 May;38(5):855-862.
- doi: 10.4097/kjae.2000.38.5.855
BACKGROUND: The aim of this study was to evaluate the effect of 4-aminopyridine (4-AP) combined with anticholiesterase (antiChE) in antagonizing MgSO4-rocuronium-induced neuromuscualr blockade using a rat hemidiaphragm. METHODS: A hemidiaphragm with... -
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- 4 Aminopyridine Induced Epileptiform Activity
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Choi BJ, Whang KT
- KMID: 2177014
- J Korean Child Neurol Soc.
- 2005 May;13(1):63-68.
PURPOSE: The goal of the present study was to investigate the effects of 4-aminopyridine(4-AP) on the excitability of visual cortex, observe the induction of epileptiform activity and define the characteristics... -
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- 4-Aminopyridine Improves Lower Urinary Tract Symptoms in a Patient With Benign Prostatic Hyperplasia and Downbeat Nystagmus Syndrome
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Strupp M, Feil K, Bardins S, Waidelich
- KMID: 2232736
- Int Neurourol J.
- 2014 Dec;18(4):221-225.
- doi: 10.5213/inj.2014.18.4.221
Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders. Here we present a patient with... -
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- Effects of K+ channel modulators on extracellular K+ accumulation during ischemia in the rat hippocampal slice
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Choi JK, Chun BG, Ryu PD
- KMID: 2285186
- Korean J Physiol Pharmacol.
- 1997 Dec;1(6):681-690.
Loss of synaptic transmission and accumulation of extracellular K+((K+)o) are the key features in ischemic brain damage. Here, we examined the effects of several K+ channel modulators on the early ischemic changes in... -
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- Relaxant effect of 4-aminopyridine on the mesenteric artery of rat
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Kim SH, Lee TI
- KMID: 1581024
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):463-469.
It has been well known that 4-aminopyridine (4-AP) has an excitatory effect on vascular smooth muscle due to causing membrane depolarization by blocking K+-channel. However, we observed that 4-AP had an inhibitory effect... -
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- Neuromuscular Blocking Properties of Dantrolene at the Neuromuscular Junction and Its Recovery with Various Antagonists
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Kim SY, Lee JS
- KMID: 2091651
- Korean J Anesthesiol.
- 2001 Dec;41(6):S1-S6.
- doi: 10.4097/kjae.2001.41.6.S1
BACKGROUND: Dantrolene produces skeletal muscle relaxation by a direct action on excitation-contraction coupling, presumably by decreasing the amount of calcium released from the sarcoplasmic reticulum. The mechanism underlying this... -
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- Effects of Pseudocholinesterase, Anticholinesterase, and 4-Aminopyridine to the Mivacurium-induced Neuromuscular Block on Rat Diaphragm
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Kim YI, Kang KS, Hwang KH, Yang HS, Kim SY, Song JE
- KMID: 2237746
- Korean J Anesthesiol.
- 1997 Jun;32(6):865-873.
- doi: 10.4097/kjae.1997.32.6.865
BACKGROUND: Prolongation of the neuromuscular block of mivacurium can occur when there is a genetic deficiency of the enzyme or in the presence of anticholinesterase (AntiChE) which inhibit the activity... -
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- 4-Aminopyridine Inhibits the Large-conductance Ca2+ -activated K+ Channel (BKCa) Currents in Rabbit Pulmonary Arterial Smooth Muscle Cells
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Bae YM, Kim A, Kim B, Cho SI, Kim J, Earm YE
- KMID: 1607350
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):25-28.
Ion channel inhibitors are widely used for pharmacological discrimination between the different channel types as well as for determination of their functional role. In the present study, we tested the... -
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- Effects of Potassium Channel Modulators on Contractile Responses of Isolated Rat Vas Deferens to Field Stimulation
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Baik YH, Kim YM, Rhu BS
- KMID: 1973325
- Chonnam Med J.
- 2002 Mar;38(1):17-23.
Apart from regulating the resting membrane potential, K+ channels might also participate in cellular activity in response to endogenous neurotransmitters and exogenous agents. K+ channel modulators including 4 - aminopyridine... -
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- The Neuromuscular Blocking Effect of Mivacurium in Isolated Rat Phrenic-Hemidiaphragm with Long-term Phenytoin Pretreatment
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Ryu TG, Kim JS, Lee MK, Park YC, Lim SH, Choi YS, Yoon SM
- KMID: 2091122
- Korean J Anesthesiol.
- 1997 Aug;33(2):237-242.
- doi: 10.4097/kjae.1997.33.2.237
BACKGROUND: Long-term phenytoin therapy induces resistance to the neuromuscular blocking effects of metocurine, atracurium, doxacurium, and pipecuronium. This study examine neuromuscu-lar blocking effect and recovery of mivacurium in isolated rat... -
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- Inhibitory Effects of Norepinephrine on the Potassium Current of Rat Medial Vestibular Nuclear Neurons
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Jeong HS, Jang MJ, Huang M, Huh HR, Cho KH, Kim BC, Park JS
- KMID: 1626909
- J Korean Neurol Assoc.
- 2005 Jun;23(3):363-367.
BACKGROUND: This study aimed to explore the effects of norepinephrine on the potassium currents of rat medial vestibular nuclear neurons by using the whole-cell patch clamp technique. METHODS: Sprague-Dawley rats... -
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- 4-Aminopyridine (4-AP) augments Ca(2+)-dependent action potential and changes oscillatory firing patterns in rat cerebellar Purkinje cells
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Seo WS, Shin JH, Suh CK
- KMID: 711623
- Yonsei Med J.
- 1999 Apr;40(2):112-117.
- doi: 10.3349/ymj.1999.40.2.112
Intracellular recordings in cerebellar slice preparation showed that applications of 4-AP altered the pattern of oscillatory firing activity in Purkinje cells (PCs), especially yielding pronounced changes in action... -
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- Pressor Effect of Intracerebroventricular 4-Aminopyridine on the Systemic Arterial Pressure in the Rabbit
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Lim JS, Kang SY, Baik YH, Kang SS
- KMID: 1955534
- J Korean Neurosurg Soc.
- 1998 Aug;27(8):1015-1022.
A K+-channel blocker, 4-aminopyridine(4-AP) increases neurotransmitter release from motor nerve terminals and has been shown to restore neuromuscular transmission in the myasthenic syndrome. It has been reported that the intravenous... -
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- Anticonvulsant Effect of Flutamide in vitro Seizure Model
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Kim WJ, Lee SY, Lee BI
- KMID: 1480900
- J Korean Epilepsy Soc.
- 2008 Dec;12(2):92-95.
PURPOSE: Flutamide (4-nitro-3-t-trifluoromethyl-isobutyranilide) is an androgen-receptor antagonist with typical antiandrogenic effect, used to treat androgen-dependent disorders such as prostate cancer. However, some reports noted that flutamide has direct effects to... -
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- Combined Application of Bicuculline and 4-Aminopyridine-Induced Epileptiform Activity are Resistant to Conventional Anticonvulsants and AMPA in Young Rat Visual Cortex
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Choi BJ
- KMID: 1816508
- J Korean Epilepsy Soc.
- 2006 Jun;10(1):35-40.
PURPOSE: The goal of the present study was to find out whether blockade of GABAergic synaptic transmission by bicuculline (BIC) in the presence of 4-aminopyridine (4-AP) would lead to expression... -
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- Echinacoside, an active constituent of Herba Cistanche, suppresses epileptiform activity in hippocampal CA3 pyramidal neurons
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Lu CW, Huang SK, Lin TY, Wang SJ
- KMID: 2410089
- Korean J Physiol Pharmacol.
- 2018 May;22(3):249-255.
- doi: 10.4196/kjpp.2018.22.3.249
Echinacoside, an active compound in the herb Herba Cistanche, has been reported to inhibit glutamate release. In this study, we investigated the effects of echinacoside on spontaneous excitatory synaptic transmission... -
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- Altered Contractility of the in vivo Feline Trabecular Smooth Muscle under Acidosis
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Moon DG, Kwak TI, Kim JJ
- KMID: 2290151
- Korean J Urol.
- 1998 Aug;39(8):744-750.
PURPOSE: Previous studies concerning the ischemic priapism revealed that hypoxia alter the erectile and contractile responses of penis. But the effects of accompaning acidosis on the trabecular smooth muscle contractility... -
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- Characterization of Ionic Currents in Human Neural Stem Cells
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Lim CG, Kim SS, Suh-Kim H, Lee YD, Ahn SC
- KMID: 1838349
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):131-135.
- doi: 10.4196/kjpp.2008.12.4.131
The profile of membrane currents was investigated in differentiated neuronal cells derived from human neural stem cells (hNSCs) that were obtained from aborted fetal cortex. Whole-cell voltage clamp recording revealed... -
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- Two types of voltage-dependent outward potassium currents in smooth muscle cells of rabbit basilar artery
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Kang TM, So I, Uhm DY, Kim KW
- KMID: 1554553
- Korean J Physiol Pharmacol.
- 1997 Apr;1(2):169-183.
We have investigated the two types of voltage-dependent outward potassium (K) currents, i.e. delayed rectifier K current (I-K(V)) and 'A-like' transient outward K current (I-to) with patch-clamp technique in single smooth muscle cells... -
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