- The electroretinographic change by the acute effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Kim DM, Lee J
- KMID: 1734993
- Korean J Ophthalmol.
- 1987 Jun;1(1):8-17.
- doi: 10.3341/kjo.1987.1.1.8
The electrophysiological effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkey, on the pigmented rabbit retina were determined under acute conditions. The amplitude of the b-wave... -
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- The Role of Axonopathy in Parkinson's Disease
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O'Malley K
- KMID: 1460755
- Exp Neurobiol.
- 2010 Dec;19(3):115-119.
- doi: 10.5607/en.2010.19.3.115
New genetic and environmental studies of Parkinson's disease have revealed early problems in synaptic function and connectivity indicating that axonal impairment may be an important hallmark in this disorder. Since... -
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- Changes of Locomotor Activity and Biogenic Amines by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 Mice
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Heo JH, Kim JS, Bahng HR, Kim DG
- KMID: 1957291
- J Korean Neurol Assoc.
- 1994 Dec;12(4):593-603.
The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rodents was investigated by measuring the locomotor activity and the changes of brain biogenic amines in MPTP-treated C57BL/6 mice. The mice showed a typical... -
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- 1alpha,25-Dihydroxyvitamin D3 Protects Dopaminergic Neurons in Rodent Models of Parkinson's Disease through Inhibition of Microglial Activation
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Kim JS, Ryu SY, Yun I, Kim WJ, Lee KS, Park JW, Kim YI
- KMID: 1980465
- J Clin Neurol.
- 2006 Dec;2(4):252-257.
- doi: 10.3988/jcn.2006.2.4.252
BACKGROUND: Recent studies have demonstrated the molecular basis of the immunomodulatory and anti-inflammatory activities of 1,25-dihydroxyvitamin D3(1,25-(OH)2D3). This hormone improves behavioral deficits and normalizes the nigral dopamine levels in animal... -
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- Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains
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Lee KS, Lee JK, Kim HG, Kim HR
- KMID: 1432768
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):89-97.
- doi: 10.4196/kjpp.2013.17.1.89
Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before... -
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- Behavioral and Histochemical Changes in MPTP-treated C57BL/6 Mice: A Model for Parkinson's Disease
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Kim JW, Lee SK, Ha KM
- KMID: 2138112
- J Korean Neurol Assoc.
- 1993 Jun;11(2):175-180.
The effects of 1-methyl-4-phenyl-1, 2. 3, 6-tetrahydropyridine (MPTP) on behavioral and histochemical changes were investigated in C57BL/6 mice. For immunocytochemis try, one group of mice received a dose of 2X30mg/kg... -
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- Effects of a Silkworm Extract on Dopamine and Monoamine Oxidase-B Activity in an MPTP-induced Parkinsons Disease Model
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Kang YK, Oh HS, Cho YH, Kim YJ, Han YG, Nam SH
- KMID: 2312079
- Lab Anim Res.
- 2010 Sep;26(3):287-292.
The protective efficacy of a silkworm extract (SE) on N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism and its possible mechanisms were studied in C57BL/6 mice. Mice were administrated intraperitoneally with SE (20 mg/kg/day) for... -
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- Effects of Nicotine on MPTP-induced Parkinson's Disease Animal Model
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Kim HJ, Park KH, Oh SO, Kim Y, Yoon S, Baek SY
- KMID: 1472488
- Korean J Anat.
- 2009 Sep;42(3):161-169.
Parkinson's disease (PD) is a progressive neurological disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Despite extensive researches, the etiology of this disease... -
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- Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources
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Hwang DJ, Kwon KC, Song HK, Kim KS, Jung YS, Hwang DY, Cho JY
- KMID: 2470109
- Lab Anim Res.
- 2019 Aug;35(2):61-69.
- doi: 10.1186/s42826-019-0012-2
MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is commonly used to induce nigrostriatal defects to induce parkinsonism and/or parkinsonian syndrome, to replicate the lesions seen in Parkinson's disease (PD), with use in numerous PD models... -
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- Glycyrrhizin Attenuates MPTP Neurotoxicity in Mouse and MPP+-Induced Cell Death in PC12 Cells
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Kim YJ, Lee CS
- KMID: 1486145
- Korean J Physiol Pharmacol.
- 2008 Apr;12(2):65-71.
- doi: 10.4196/kjpp.2008.12.2.65
The present study examined the inhibitory effect of licorice compounds glycyrrhizin and a metabolite 18 beta-lycyrrhetinic acid on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse and on the 1-methyl-4-phenylpyridinium... -
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- The Effect of MPTP on Movement and TH-immunoreactive Neuronal Changes of C57BL/6 Mice in Relation to Aging
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Kim JW, Baek SY, Yoon HW
- KMID: 1530497
- Korean J Anat.
- 1999 Jun;32(3):421-424.
The effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on movement and tyrosine hydroxylase (TH)-immunoreactive (ir) neuronal changes in young (5~6 weeks) and aged (10~12 months) C57BL/6 mice were studied. Locomotor... -
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- Inhibition of Oxidative Tissue Damage and Mitochondrial Dysfunction by Glycyrrhizin in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease
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Park SE, Hong KM, Han JH, Kim DE, Lee CS
- KMID: 2343255
- J Korean Neurol Assoc.
- 2007 Aug;25(3):353-363.
BACKGROUND: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces an irreversible and severe parkinsonian-like syndrome. A licorice compound glycyrrhizin exerts a cytoprotective or anti-oxidant effect in various disease conditions, but its effect against the MPTP-induced... -
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- Effects of (−)-Sesamin on Memory Deficits in MPTP-lesioned Mouse Model of Parkinson's Disease
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Zhao TT, Shin KS, Lee MK
- KMID: 2366691
- Nat Prod Sci.
- 2016 Dec;22(4):246-251.
- doi: 10.20307/nps.2016.22.4.246
This study investigated the effects of (−)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits... -
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- The Effect of MPTP in The Mouse Brain in Relation to Aging: Immunocytochemical Analysis
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Kim JW, Lee SK, Ha KM
- KMID: 2342392
- J Korean Neurol Assoc.
- 1994 Jun;12(2):183-187.
The effect of MPTP on catecholamine neurons in young (4-6 weeks) and aging (10-12 months) C57BL/6 mice was studied using immunocytochemical techniques. Both groups of mice received 4 repeated dosages... -
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- Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice
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Ye M, Chung HS, Lee C, Song JH, Shim I, Kim YS, Bae H
- KMID: 2361531
- Exp Mol Med.
- 2016 Jul;48(7):e244.
- doi: 10.1038/emm.2016.49
α-Synuclein (α-Syn) has a critical role in microglia-mediated neuroinflammation, which leads to the development of Parkinson's disease (PD). Recent studies have shown that bee venom (BV) has beneficial effects on... -
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- The Effect of Ginseng Saponin on the Dopaminergic Neurons in the Parkinson's Disease Model in Mice
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Kim CO, Kim KS, Huh YB, Ahn BW, Han BS, Choi KS, Nam KY, Juhng SW
- KMID: 1849798
- Korean J Pathol.
- 1997 Sep;31(9):805-814.
Saponin has been known to be a major antioxidant component in panax ginseng. Recent experimental study suggests that some antioxidant materials prevent Parkinson's disease caused by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) in... -
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- Behavior, PET and Histology in Novel Regimen of MPTP Marmoset Model of Parkinson's Disease for Long-Term Stem Cell Therapy
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Yun JW, Ahn JB, Kwon E, Ahn JH, Park HW, Heo H, Park JS, Kim H, Paek SH, Kang BC
- KMID: 2360872
- Tissue Eng Regen Med.
- 2016 Feb;13(1):100-109.
- doi: 10.1007/s13770-015-0106-3
Stem cell technologies are particularly attractive in Parkinson's disease (PD) research although they occasionally need long-term treatment for anti-parkinsonian activity. Unfortunately, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) widely used as a model for PD... -
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- Proposed Motor Scoring System in a Porcine Model of Parkinson's Disease induced by Chronic Subcutaneous Injection of MPTP
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Moon JH, Kim JH, Im HJ, Lee DS, Park EJ, Song K, Oh HJ, Hyun SB, Kang SC, Kim H, Moon HE, Park HW, Lee HJ, Kim EJ, Kim S, Lee BC, Paek SH
- KMID: 2165531
- Exp Neurobiol.
- 2014 Sep;23(3):258-265.
- doi: 10.5607/en.2014.23.3.258
Destruction of dopaminergic neurons in the substantia nigra pars compacta (SNpc) is a common pathophysiology of Parkinson's disease (PD). Characteristics of PD patients include bradykinesia, muscle rigidity, tremor at rest... -
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- Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
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Park JS, Leem YH, Park JE, Kim DY, Kim HS
- KMID: 2442009
- Biomol Ther.
- 2019 Feb;27(2):178-184.
- doi: 10.4062/biomolther.2018.234
Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a... -
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- Nicotine Prevents MPTP-induced Dopaminergic Neurodegeneration
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Kim JM, O JJ, Jeon BS
- KMID: 2165288
- Exp Neurobiol.
- 2008 Dec;17(2):95-100.
- doi: 10.5607/en.2008.17.2.95
Epidemiological studies of Parkinson disease (PD) have found an inverse correlation between cigarette smoking and the risk of developing PD, which suggests that nicotine has a protective effect. Results from... -
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