- Nuclear receptor regulation of stemness and stem cell differentiation
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Jeong Y, Mangelsdorf DJ
- KMID: 1119318
- Exp Mol Med.
- 2009 Aug;41(8):525-537.
- doi: 10.3858/emm.2009.41.8.091
Stem cells include a diverse number of toti-, pluri-, and multi-potent cells that play important roles in cellular genesis and differentiation, tissue development, and organogenesis. Genetic regulation involving various transcription... -
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- CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells
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Lee EJ, Lee HG, Park SH, Choi EY, Park SH
- KMID: 1093617
- Exp Mol Med.
- 2003 Oct;35(5):438-447.
CD99 is a 32-kDa cell surface molecule present on thymocytes, peripheral T cells, many other hematopoietic stem cells and somatic cells were implicated in cell-cell adhesion and cell-activation phenomena. Two... -
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- Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27
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Seo YJ, Jeon MH, Lee JH, Lee YJ, Youn HJ, Ko JH, Lee JH
- KMID: 1116208
- Exp Mol Med.
- 2005 Dec;37(6):624-630.
Bis (Bag-3, CAIR), a Bcl-2-interacting protein, promotes the anti-apoptotic activity of Bcl-2 and increased levels of Bis have been observed in several disease models. The involvement of Bcl-2 and some... -
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- Expression of hOGG1 protein during differentiation of HL-60 cells
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Lee YS, Lee KH, Chung MH
- KMID: 1097257
- Exp Mol Med.
- 2003 Apr;35(2):98-105.
Human 8-oxo-G-DNA glycosylase 1 (hOGG1) is a DNA glycosylase to cleave 8-oxo-7,8-dihydroguanine (8-oxo-G), a mutagenic DNA adduct formed by oxidant stresses. Here, we examined hOGG1 protein expression and repair activity... -
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- Isolation of neural precursor cells from skeletal muscle tissues and their differentiation into neuron-like cells
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Park JS, Kim S, Han DK, Lee JY, Ghil SH
- KMID: 756071
- Exp Mol Med.
- 2007 Aug;39(4):483-490.
Skeletal muscle contains several precursor cells that generate muscle, bone, cartilage and blood cells. Although there are reports that skeletal muscle-derived cells can trans-differentiate into neural-lineage cells, methods for isolating... -
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- Roles of gangliosides in mouse embryogenesis and embryonic stem cell differentiation
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Kwak DH, Seo BB, Chang KT, Choo YK
- KMID: 1015456
- Exp Mol Med.
- 2011 Jul;43(7):379-388.
- doi: 10.3858/emm.2011.43.7.048
Gangliosides have been suggested to play important roles in various functions such as adhesion, cell differentiation, growth control, and signaling. Mouse follicular development, ovulation, and luteinization during the estrous cycle... -
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- Bone Morphogenetic Protein Receptor in the Osteogenic Differentiation of Rat Bone Marrow Stromal Cells
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Wang A, Ding X, Sheng S, Yao Z
- KMID: 1071427
- Yonsei Med J.
- 2010 Sep;51(5):740-745.
- doi: 10.3349/ymj.2010.51.5.740
PURPOSE: Several signaling pathways have been shown to regulate the lineage commitment and terminal differentiation of bone marrow stromal cells (BMSCs). Bone morphogenetic protein (BMP) signaling has important effects on... -
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- Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells
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Seo MS, Jeong YH, Park JR, Park SB, Rho KH, Kim HS, Yu KR, Lee SH, Jung JW, Lee YS, Kang KS
- KMID: 1726916
- J Vet Sci.
- 2009 Sep;10(3):181-187.
- doi: 10.4142/jvs.2009.10.3.181
Human umbilical cord blood-derived mesenchymal stem cells (MSCs) are known to possess the potential for multiple differentiations abilities in vitro and in vivo. In canine system, studying stem cell therapy... -
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- Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP)
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Schubert T, Schlegel J, Schmid R, Opolka A, Grassel S, Humphries , Bosserhoff AK
- KMID: 946649
- Exp Mol Med.
- 2010 Mar;42(3):166-174.
- doi: 10.3858/emm.2010.42.3.017
Melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP) is a small soluble protein secreted from malignant melanoma cells and from chondrocytes. Recently, we revealed that MIA/CD-RAP can modulate bone morphogenetic protein... -
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- Expression of N-terminal truncated desmoglein 3 (Delta NDg3) in epidermis and its role in keratinocyte differentiation
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Lee JS, Yoon HK, Sohn KC, Back SJ, Kee SH, Seo YJ, Park JK, Kim CD, Lee JH
- KMID: 756285
- Exp Mol Med.
- 2009 Jan;41(1):42-50.
- doi: 10.3858/emm.2009.41.1.006
During a search for keratinocyte differentiation-related genes, we obtained a cDNA fragment from the 5'-untranslated region of a previously identified splicing variant of desmoglein 3 (Dg3). This transcript encodes a... -
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- Alterations of proliferative and differentiation potentials of human embryonic stem cells during long-term culture
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Park YB, Kim YY, Oh SK, Chung SG, Ku SY, Kim SH, Choi YM, Moon SY
- KMID: 1103593
- Exp Mol Med.
- 2008 Feb;40(1):98-108.
- doi: 10.3858/emm.2008.40.1.98
Human embryonic stem cells (hESCs) are considered to be able to stably maintain their characteristics in vitro for prolonged periods, but we had previously encountered changes in proliferative ability and... -
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- Hematopoietic Differentiation of Embryoid Bodies Derived from the Human Embryonic Stem Cell Line SNUhES3 in Co-culture with Human Bone Marrow Stromal Cells
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Kim SJ, Kim BS, Ryu SW, Yoo JH, Oh JH, Song CH, Kim SH, Choi DS, Seo JH, Choi CW, Shin SW, Kim YH, Kim JS
- KMID: 2158151
- Yonsei Med J.
- 2005 Oct;46(5):693-699.
- doi: 10.3349/ymj.2005.46.5.693
Human embryonic stem (ES) cells can be induced to differentiate into hematopoietic precursor cells via two methods: the formation of embryoid bodies (EBs) and co-culture with mouse bone marrow (BM)... -
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- Enhanced proliferation and differentiation of Oct4- and Sox2-overexpressing human adipose tissue mesenchymal stem cells
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Han SM, Han SH, Coh YR, Jang G, Chan Ra J, Kang SK, Lee HW, Youn HY
- KMID: 2155366
- Exp Mol Med.
- 2014 Jun;46(6):e101.
- doi: 10.1038/emm.2014.28
Mesenchymal stem cells (MSCs) are attractive candidates for clinical repair or regeneration of damaged tissues. Oct4 and Sox2, which are essential transcription factors for pluripotency and self-renewal, are naturally expressed... -
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- Involvement of the Ca2+ signaling pathway in osteoprotegerin inhibition of osteoclast differentiation and maturation
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Fu Y, Gu J, Wang Y, Yuan Y, Liu X, Bian J, Liu ZP
- KMID: 2164523
- J Vet Sci.
- 2015 Jun;16(2):151-156.
- doi: 10.4142/jvs.2015.16.2.151
The purpose of this study was to determine whether the Ca2+ signaling pathway is involved in the ability of osteoprotegerin (OPG) to inhibit osteoclast differentiation and maturation. RAW264.7 cells were... -
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- Regulation of matrix metalloproteinase-9 protein expression by 1alpha,25-(OH)2D3 during osteoclast differentiation
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Gu JH, Tong XS, Chen GH, Liu XZ, Bian JC, Yuan Y, Liu ZP
- KMID: 1737619
- J Vet Sci.
- 2014 Mar;15(1):133-140.
- doi: 10.4142/jvs.2014.15.1.133
To investigate 1alpha,25-(OH)2D3 regulation of matrix metalloproteinase-9 (MMP-9) protein expression during osteoclast formation and differentiation, receptor activator of nuclear factor kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) were administered... -
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- Regulation of osteogenic differentiation of human adipose-derived stem cells by controlling electromagnetic field conditions
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Kang KS, Hong JM, Kang JA, Rhie JW, Jeong YH, Cho DW
- KMID: 2154225
- Exp Mol Med.
- 2013 Jan;45(1):e6.
Many studies have reported that an electromagnetic field can promote osteogenic differentiation of mesenchymal stem cells. However, experimental results have differed depending on the experimental and environmental conditions. Optimization of... -
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- Isolation and characterization of equine amniotic membrane-derived mesenchymal stem cells
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Seo MS, Park SB, Kim HS, Kang JG, Chae JS, Kang KS
- KMID: 1705516
- J Vet Sci.
- 2013 Jun;14(2):151-159.
- doi: 10.4142/jvs.2013.14.2.151
Recent studies have shown that mesenchymal stem cells (MSCs) are able to differentiate into multi-lineage cells such as adipocytes, chondroblasts, and osteoblasts. Amniotic membrane from whole placenta is a good... -
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- Use of Long-term Cultured Embryoid Bodies May Enhance Cardiomyocyte Differentiation by BMP2
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Kim YY, Ku SY, Jang J, Oh SK, Kim HS, Kim SH, Choi YM, Moon SY
- KMID: 2158201
- Yonsei Med J.
- 2008 Oct;49(5):819-827.
- doi: 10.3349/ymj.2008.49.5.819
PURPOSE: Human embryonic stem cells (hESCs) can proliferate for a prolonged period and differentiate into cardiomyocytes in vitro. Recent studies used bone morphogenetic protein 2 (BMP2) to generate cardiomyocytes from... -
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- Efficient gene delivery in differentiated human embryonic stem cells
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Kim JH, Do HJ, Choi SJ, Cho HJ, Park KH, Yang HM, Lee SH, Kim DK, Kwack K, Oh SK, Moon SY, Cha KY, Chung HM
- KMID: 1033099
- Exp Mol Med.
- 2005 Feb;37(1):36-44.
Human embryonic stem (hES) cells are capable of differentiating into pluralistic cell types, however, spontaneous differentiation generally gives rise to a limited number of specific differentiated cell types and a... -
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- Differentiation of Human Dental Pulp Stem Cells into Dopaminergic Neuron-like Cells in Vitro
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Chun SY, Soker S, Jang YJ, Kwon TG, Yoo ES
- KMID: 2360038
- J Korean Med Sci.
- 2016 Feb;31(2):171-177.
- doi: 10.3346/jkms.2016.31.2.171
We investigated the potential of human dental pulp stem cells (hDPSCs) to differentiate into dopaminergic neurons in vitro as an autologous stem cell source for Parkinson's disease treatment. The hDPSCs... -
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