- Effects of intracellular pH on apoptosis in HL-60 human leukemia cells
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Park HJ
- KMID: 699858
- Yonsei Med J.
- 1995 Dec;36(6):473-479.
- doi: 10.3349/ymj.1995.36.6.473
The nature of the endonucleases responsible for DNA fragmentation in apoptosis has not yet been clearly defined. The intracellular acidity has been known to greatly affect apoptosis probably by affecting... -
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- Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells
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Kwon D, Choi IH
- KMID: 1779506
- Yonsei Med J.
- 2006 Aug;47(4):551-557.
- doi: 10.3349/ymj.2006.47.4.551
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing... -
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- Pro-apoptotic function of hepatitis B virus X protein
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Kim KH
- KMID: 1792589
- Korean J Hepatol.
- 2010 Jun;16(2):112-122.
- doi: 10.3350/kjhep.2010.16.2.112
Infection of hepatitis B virus (HBV) is a main cause of liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Among the HBV-encoded proteins, the HBV X protein (HBx) has... -
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- Apoptosis of Skeletal Muscle on Steroid-Induced Myopathy in Rats
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Lee MJ, Lee JS, Lee MC
- KMID: 648306
- J Korean Med Sci.
- 2001 Aug;16(4):467-474.
- doi: 10.3346/jkms.2001.16.4.467
Recently apoptotic cell death has been reported in differentiated skeletal muscle, where apoptosis was generally assumed not to occur. To investigate whether apoptosis may contribute to the steroid-induced myopathy, rats... -
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- GD3 Accumulation in Cell Surface Lipid Rafts Prior to Mitochondrial Targeting Contributes to Amyloid-beta-induced Apoptosis
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Kim JK, Kim SH, Cho HY, Shin HS, Sung HR, Jung JR, Quan ML, Jiang DH, Bae HR
- KMID: 2157855
- J Korean Med Sci.
- 2010 Oct;25(10):1492-1498.
- doi: 10.3346/jkms.2010.25.10.1492
Neuronal apoptosis induced by amyloid beta-peptide (A beta) plays an important role in the pathophysiology of Alzheimer's disease (AD). However, the molecular mechanism underlying A beta-induced apoptosis remains undetermined. The... -
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- Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin
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Zhang HY, Du ZX, Liu BQ, Gao YY, Meng X, Guan Y, Deng WW, Wang HQ
- KMID: 1123811
- Exp Mol Med.
- 2009 May;41(5):362-369.
- doi: 10.3858/emm.2009.41.5.041
TNF-related apoptosis-inducing ligand (TRAIL) has been proposed as a promising cancer therapy that preferentially induces apoptosis in cancer cells, but not most normal tissues. However, many cancers are resistant to... -
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- Methylglyoxal Induces Apoptosis Mediated by Reactive Oxygen Species in Bovine Retinal Pericytes
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Kim J, Son JW, Lee JA, Oh YS, Shinn SH
- KMID: 1785701
- J Korean Med Sci.
- 2004 Feb;19(1):95-100.
- doi: 10.3346/jkms.2004.19.1.95
One of the histopathologic hallmarks of early diabetic retinopathy is the loss of pericytes. Evidences suggest that the pericyte loss in vivo is mediated by apoptosis. However, the underlying cause... -
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- Distinct Patterns of Cleavage and Translocation of Cell Cycle Control Proteins in CD95-induced and p53-induced apoptosis
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Park WS, Jung KC, Chung DH, Nam WD, Choi WJ, Bae Y
- KMID: 648894
- J Korean Med Sci.
- 2003 Aug;18(4):467-472.
- doi: 10.3346/jkms.2003.18.4.467
Apoptotic cell death induced by p53 occurs at a late G1 cell cycle checkpoint termed the restriction(R)point, and it has been proposed that p53-induced apoptosis causes upregulation of CD95. However,... -
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- Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin
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Shin EC, Seong YR, Kim CH, Kim H, Ahn YS, Kim K, Kim SJ, Hong SS, Park JH
- KMID: 1081460
- Exp Mol Med.
- 2002 May;34(2):114-122.
TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, selectively induce apoptosis in various transformed cell lines but not in almost-normal tissues. It is regulated by 2 death receptors,... -
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- Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression
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Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH
- KMID: 964666
- Exp Mol Med.
- 2010 Oct;42(10):712-720.
- doi: 10.3858/emm.2010.42.10.070
Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum... -
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- Delayed Human Neutrophil Apoptosis by Trichomonas vaginalis Lysate
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Song HO, Lim YS, Moon SJ, Ahn MH, Ryu JS
- KMID: 1102780
- Korean J Parasitol.
- 2010 Mar;48(1):1-7.
- doi: 10.3347/kjp.2010.48.1.1
Neutrophils play an important role in the human immune system for protection against such microorganisms as a protozoan parasite, Trichomonas vaginalis; however, the precise role of neutrophils in the pathogenesis... -
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- Galpha12 Protects Vascular Endothelial Cells from Serum Withdrawal-Induced Apoptosis through Regulation of miR-155
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Lee HJ, Lee EJ, Seo M
- KMID: 2466377
- Yonsei Med J.
- 2016 Jan;57(1):247-253.
- doi: 10.3349/ymj.2016.57.1.247
PURPOSE: Apoptosis of vascular endothelial cells is a type of endothelial damage that is associated with the pathogenesis of cardiovascular diseases such as atherosclerosis. Heterotrimeric GTP-binding proteins (G proteins), including... -
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- Time Dependent Bladder Apoptosis Induced by Acute Bladder Outlet Obstruction and Subsequent Emptying is Associated with Decreased MnSOD Expression and Bcl-2/Bax Ratio
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Li WJ, Shin MK, Oh SJ
- KMID: 1779237
- J Korean Med Sci.
- 2010 Nov;25(11):1652-1656.
- doi: 10.3346/jkms.2010.25.11.1652
Ischemia/reperfusion (I/R) injury-induced oxidative stress plays an important role in the functional impairment of the bladder following acute bladder outlet obstruction (BOO) via induction of apoptosis. The purpose of this... -
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- Expression of CD40 in Gastric Cancer and Its Effect on the Apoptosis of Gastric Cancer Cells
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Kim SW, Lee HS, Yoon SK, Chung WC, Cho YS, Jeong JJ, Lee IS, Lee KM, Lee DS, Choi MG, Chung IS, Park DH
- KMID: 772557
- Korean J Gastroenterol.
- 2003 Oct;42(4):274-282.
BACKGROUND/AIMS: The expression of CD40 in gastric cancer has not been studied. The aims of this study were to determine the expression of CD40 in gastric cancer and to investigate... -
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- Comparative Ki-67 Expression and Apoptosis in the Odontogenic Keratocyst Associated with or without an Impacted Tooth in Addition to Unilocular and Multilocular Varieties
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Kim DK, Ahn SG, Kim J, Yoon JH
- KMID: 2428352
- Yonsei Med J.
- 2003 Oct;44(5):841-846.
It is not known whether the presence of an impacted tooth or the radiographic types in an odontogenic keratocyst (OKC) change the clinical biologic behavior and therapeutic approaches. This study... -
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- Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells
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Choi BH, Chakraborty G, Baek K, Yoon HS
- KMID: 2154266
- Exp Mol Med.
- 2013 Oct;45(10):e47.
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38... -
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- Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation
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Moon MH, Jeong JK, Seo JS, Seol JW, Lee YJ, Xue M, Jackson CJ, Park SY
- KMID: 1109402
- Exp Mol Med.
- 2011 Mar;43(3):138-145.
- doi: 10.3858/emm.2011.43.3.016
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant... -
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- Aldosterone Modulates Cell Proliferation and Apoptosis in the Neonatal Rat Heart
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Sohn HJ, Yoo KH, Jang GY, Lee JH, Choi BM, Lee JH, Bae IS, Yim HE, Son CS, Lee JW
- KMID: 1785908
- J Korean Med Sci.
- 2010 Sep;25(9):1296-1304.
- doi: 10.3346/jkms.2010.25.9.1296
In the present study, we investigated whether and how the mineralocorticoid receptor antagonist spironolactone affects cardiac growth and development through apoptosis and cell proliferation in the neonatal rat heart. Newborn... -
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- Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity
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Kim HS, Jeong SY, Lee JH, Kim BE, Kim JW, Jeong SW, Kim IK
- KMID: 755099
- Exp Mol Med.
- 2000 Dec;32(4):197-203.
3-Deazaadenosine (DZA), one of the potent inhibitors of S-adenosylhomocysteine hydrolase, is known to possess several biological properties including an induction of apoptosis. To evaluate a possibility that DZA... -
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- Developmental changes in cell proliferation and apoptosis in the normal duck bursa of Fabricius
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Fang J, Peng X
- KMID: 2070232
- J Vet Sci.
- 2014 Dec;15(4):465-474.
- doi: 10.4142/jvs.2014.15.4.465
The aim of this work was to investigate developmental changes in cell proliferation and apoptosis in normal duck bursa of Fabricius using flow cytometry and immunohistochemistry. Studies were carried out... -
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